MINIATURE GUIDANCE AND NAVIGATION CONTROL (miniGNC) ANTIBODY-LIKE PROTEINS AND METHODS OF MAKING AND USING THEREOF

ABSTRACT

A multi-specific antibody-like protein having a first monomer comprising a first binding monomer, a CH1 domain, a first hinge, a first CH2 domain, and a first CH3 domain, a second monomer comprising a second binding monomer, a CL domain, a second hinge, a second CH2 domain, and a second CH3 domain, wherein the first binding monomer and a second binding monomer are configured to form a dimer, wherein the first monomer and the second monomer are covalently paired through at least one disulfide bond between the CH1 domain and the CL domain and at least one disulfide bond between the first hinge and the second hinge, wherein the first monomer and second monomer may comprise optionally a first binding domain (D1) and a second binding domain (D2), and a fourth binding domain (D4) and a fifth binding domain (D5), and wherein the multi-specific antibody-like protein is at least bi-specific.

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of the filing date of U.S. Provisional Application Ser. No. 62/991,042 filed Mar. 17, 2020 under 35 U.S.C. 119(e), the entire disclosures of which are incorporated by reference herein.

TECHNICAL FIELD

The present application generally relates to the technical field of multi-specific antibody for cancer immunotherapy and more particularly relates to making and using miniature Guidance and Navigation Control (miniGNC) antibodies with multiple binding activities against surface molecules of both immune cells and tumor cells.

BACKGROUND

Therapeutic antibodies have become a mainstay in treatment of several diseases, including but not limited to cancer, infection, and autoimmunity. While monoclonal, monospecific antibodies provide a straightforward mechanism to treat disease, e.g., via inhibition or activation of specific signalling pathways, multi-specific antibodies allow more complex therapeutic mechanisms to be explored. By targeting multiple distinct antigens, or multiple epitopes within a single antigen, biological responses such as cell colocalization and activation can be elicited, which enables, for example, the redirection of T cells and other immune cells to the site of specific antigen-expressing tumor cells. In this way, bispecific and multi-specific antibodies have become important platforms in the field of immunooncology.

Due to the advantages of multi-specific antibody platforms, many such frameworks have been developed. One such platform is known as Guidance and Navigation Control (GNC). The GNC proteins include the proteins linking multiple functionally independent binding moieties into a single entity that is capable of bringing both effector cells and target cells together (see Applicant's applications, WO/2019/005641, WO2019191120, and PCT/US20/59230, incorporated herein in its entirety). In general, these platforms are restricted to at least two specificities, preventing the exploration of complex therapeutic mechanisms that require binding to more than two antigens. For antibody platforms with more than two specificities, the increased number of binding domains usually necessitates formation of large molecules which often have undesirable physical and biological properties. The increase in molecular weight can reduce developability, as larger and more complex molecules are more likely to have problems with aggregation and solubility. Furthermore, the ability of large macromolecules to penetrate into solid tumors may be hindered compared to proteins of smaller size. Thus, there is a need for multi-specific antibody platforms with more than two specificities that are not significantly larger than monoclonal IgG antibodies.

SUMMARY

The following summary is illustrative only and is not intended to be in any way limiting. In addition to the illustrative aspects, embodiments, and features described above, further aspects, embodiments, and features will become apparent by reference to the drawings and the following detailed description.

The application provides proteins with binding specificities such as multi-specific protein like antibodies including multi-specific antibodies, and the fragments of these binding proteins including without limitation scFv domain, Fab region, Fc domain, VH, VL, light chains, heavy chains, variable regions, and complementary determining region (CDR). The application further provides method of making and using the antibody-like proteins disclosed herein.

In one aspect, the application provides multi-specific antibody-like proteins. In one embodiment, the multi-specific antibody-like protein having a N-terminus and a C-terminus, including, a first monomer, including, from the N-terminus to the C-terminus, a first binding monomer, a CH1 domain, a first hinge, a first CH2 domain, and a first CH3 domain, wherein the first monomer may comprise optionally a first binding domain (D1) linked to the N-terminus, a fourth binding domain (D4) linked to the C-terminus, or both, a second monomer, including, from the N-terminus to the C-terminus, a second binding monomer, a CL domain, a second hinge, a second CH2 domain, and a second CH3 domain, wherein the second monomer may comprise optionally a second binding domain (D2) linked to the N-terminus, a fifth binding domain (D5) linked to the C-terminus, or both, wherein the first binding monomer and a second binding monomer are configured to form a dimer, wherein the first monomer and the second monomer are covalently paired through at least one disulfide bond between the CH1 domain and the CL domain and at least one disulfide bond between the first hinge and the second hinge, and wherein the multi-specific antibody-like protein is at least bi-specific.

In one embodiment, the multi-specific antibody-like protein may be tri-specific, tetra-specific, or penta-specific. In one embodiment, the multi-specific antibody-like protein may be monoclonal antibodies. In one embodiment, the multi-specific antibody-like protein may be purified monoclonal antibody. In one embodiment, the multi-specific antibody-like protein may be humanized antibodies.

In one embodiment, the multi-specific antibody-like protein may further comprise a disulfide bond between the first CH3 domain and a second CH3 domain.

In one embodiment, the multi-specific antibody-like protein may further comprise a second disulfide bond between the first hinge and the second hinge.

In one embodiment, connecting linkers are used between various domains. In one embodiment, the connecting linker may comprise a (G_(x)S_(y)), linker, wherein n, x, and y each independently is an integer from 1 to 10. In one embodiment, D1, D2, D4 or D5 are liked to N- or C-terminus through a linker. In one embodiment, the linker may comprise a (G_(x)S_(y)), linker. n, x, and y each independently may be an integer from 1 to 10. In one embodiment, n is 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10. In one embodiment, x is 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10. In one embodiment, y is 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10.

In one embodiment, the first CH3 domain is configured to form a hole structure, wherein the second CH3 domain is configured to form a knob structure, and wherein the first CH2 and CH3 domains and the second CH2 and CH3 domains are configured to heterodimerize to form a complementary Fc domain.

In one embodiment, the first CH3 domain may comprise at least one ‘hole’ mutation at T366S, L368A or Y407V and the second CH3 domain may comprise a ‘knob’ mutation at T366W.

In one embodiment, the Fc domain may comprise mutations at H435R/Y436F.

In one embodiment, the Fc domain is engineered to eliminate effector cell functions selected from ADCC, ADCP, or CDC.

In one embodiment, the Fc domain may comprise at least one mutation at L234A, L235A, G237A, K322A (Eu numbering). In one embodiment, the Fc region comprise mutations at L234A/L235A/G237A/K322A. In one embodiment, the Fc region comprise mutations at L234A/L235A/K322A (Eu numbering). In one embodiment, the Fc domain comprise null mutation. In one embodiment, the IgG4 Fc domain comprises the mutation S228P (Eu numbering). In one embodiment, the IgG4 Fc domain comprises the mutations S228P/F234A/L234A (Eu numbering).

In one embodiment, the heavy chain constant sequence may be derived from IgG1 or IgG4.

In one embodiment, the Fc domain may include an amino acid sequence having at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identity to SEQ ID NO. 313 or 314.

In one embodiment, the first binding monomer may comprise a VH domain, a second binding monomer may comprise a VL domain, and the VH, CH1, VL, CL domains form a Fab region as a third binding domain (D3). In one embodiment, the Fab region may comprise a disulfide bond between VH-44C and VL 100C.

In one embodiment, the first binding monomer and the second binding monomer form a NKG2D receptor as a third binding domain (D3).

In one embodiment, the D1, D2, D4, and D5 is independently a scFv domain, a VHH domain, a receptor, or a ligand.

In one embodiment, the scFv domain may have a VH domain linked to a VL domain. In one embodiment, the scFv domain have may have VH-VL orientation. In one embodiment, the scFv domain have a VL-VH orientation.

In one embodiment, the scFv domain may comprise a disulphide bond between VL and VH. In one embodiment, the disulfide bond is between VL100 and VH44 of the scFv domain. In one embodiment, the scFv domain may comprise the mutation R19S in the VH.

In one embodiment, the VHH domain may comprise the mutation R19S in the VH or VHH.

In one embodiment, at least one, two, or three of D1, D2, D4, and D5 may be scFv. In one embodiment, all of D1, D2, D4, and D5 may be scFv.

In one embodiment, at least one, two, or three of D1, D2, D4, and D5 may be a VHH domain. In one embodiment, all of D1, D2, D4, and D5 may be VHH domains.

In one embodiment, at least one, two, or three of D1, D2, D4, and D5 may be a receptor. In one embodiment, all of D1, D2, D4, and D5 may be receptors.

In one embodiment, at least one, two, or three of D1, D2, D4, and D5 may be a ligand. In one embodiment, all of D1, D2, D4, and D5 may be ligands.

In one embodiment, the D1, D2, D3, D4, and D5 each independently may have a binding specificity against an antigen selected from a T cell activating receptor, an immune cell binding receptor, an immune checkpoint molecule, a co-stimulation factor, a receptor of a leukocyte, a tumor antigen, a tumor associated antigen (TAA), a receptor of a tissue cell, a receptor of a cancer cell, or a combination thereof.

In one embodiment, the binding domain for T cell activating receptor is adjacent to the binding domain for the tumor associated antigen (TAA).

In one embodiment, T cell activating receptor may comprise CD3.

In one embodiment, an immune checkpoint receptor may comprise PD-L1, PD-1, TIGIT, TIM-3, LAG-3, CTLA4, BTLA, VISTA, PD-L2, CD160, LOX-1, siglec-15, CD47, HVEM SIRPα CSF1R, CD73, Siglec-15, CD47 or a combination thereof.

In one embodiment, a co-stimulating receptor may comprise 4-1BB, CD28, OX40, GITR, CD40L, CD40, ICOS, LIGHT, CD27, CD30, or a combination thereof.

In one embodiment, a tumor associated antigen may comprise EGFR, HER2, HER3, EGRFVIII, CD19, BCMA, CD20, CD33, CD123, CD22, CD30, ROR1, CEA, LMP1, LMP2A, Mesothelin, PSMA, EpCAM, glypican-3, gpA33, GD2, TROP2, NKG2D ligand, CD39, CLDN18.2, DLL3, HLA-G, FcRH5, GPRC5D, LIV-1, MUC1, CD138, CD70, uPAR, CD38 or a combination thereof.

In one embodiment, the D1, D2, D3, D4, and D5 each independently may have a binding specificity against an antigen selected, EGFR, HER2, HER3, EGFRvIII, ROR1, CD3, CD28, CEA, LMP1, LMP2A, Mesothelin, PSMA, EpCAM, glypican-3, gpA33, GD2, TROP2, NKG2D, NKG2D ligand, BCMA, CD19, CD20, CD33, CD123, CD22, CD30, PD-L1, PD1, OX40, 4-1BB, GITR, TIGIT, TIM-3, LAG-3, CTLA4, CD40, CD40L, VISTA, ICOS, BTLA, LIGHT, HVEM, CSF1R, CD73, CD39, CLDN18.2, DLL3, HLA-G, FcRH5, GPRC5D, LIV-1, MUC1, CD138, CD70, CD16, uPAR, Siglec-15, CD47, CD38, NKp46, PD-L2, CD160, LOX-1, SIRPα CD27 and the Fc domain may comprise a human IgG Fc domain.

In one embodiment, D1 may have a binding specificity to CD3, CD20, CEA, HER2, EGFR or NKG2D ligand. In one embodiment, D2 may have a binding specificity to HER3, EGFR, CD3, or CD19. In one embodiment, D3 may have a binding specificity to HER3, EGFR, CD3, or NKG2D ligands. In one embodiment, D4 may have a binding specificity to 4-1BB, or EGFR. In one embodiment, D5 may have a binding specificity to PD-L1 or HER3.

In one embodiment, D1 may have a binding specificity to CD3, D2 may have a binding specificity to HER3, D3 may have a binding specificity to EGFR, D4 may have a binding specificity to 4-1BB, and D5 may have a binding specificity to PD-L1.

In one embodiment, D1 may have a binding specificity to EGFR, D2 may have a binding specificity to HER3, D3 may have a binding specificity to CD3, D4 may have a binding specificity to 4-1BB, and D5 may have a binding specificity to PD-L1.

In one embodiment, D1 may have a binding specificity to EGFR, D2 may have a binding specificity to CD3, D3 may have a binding specificity to HER3, D4 may have a binding specificity to 4-1BB, and D5 may have a binding specificity to PD-L1.

In one embodiment, D1 may have a binding specificity to CD3 or EGFR, D2 may have a binding specificity to CD19, D3 may have a binding specificity to CD3 or EGFR, D4 may have a binding specificity to 4-1BB, and D5 may have a binding specificity to PD-L1.

In one embodiment, D1 and D4 each may have a binding specificity to EGFR, D2 and D5 each may have a binding specificity to HER3, and D3 may have a binding specificity to CD3.

In one embodiment, D1 may have a binding specificity to CD20, D2 may have a binding specificity to CD19, D3 may have a binding specificity to CD3, D4 may have a binding specificity to 4-1BB, and D5 may have a binding specificity to PD-L1.

In one embodiment, D1 may have a binding specificity to NKG2D ligand, D2 may have a binding specificity to CD19, D3 may have a binding specificity to CD3, D4 may have a binding specificity to 4-1BB, and D5 may have a binding specificity to PD-L1.

In one embodiment, D1 may have a binding specificity to CD3, and D3 may comprise a NKG2D receptor. In one embodiment, the protein may further comprise D2 having a binding specificity to CD19. In one embodiment, the protein may further comprise D5 having a binding specificity to PD-L1. In one embodiment, the protein may further comprise D4 having a binding specificity to 4-1BB.

In one embodiment, the multi-specific antibody-like protein is bi-specific. In one embodiment, D2 may have a binding specificity to HER3, D3 may have a binding specificity to CD3. In one embodiment, D1 may have a binding specificity to HER2, D3 may have a binding specificity to CD3. In one embodiment, D1 may have a binding specificity to EGFR, D3 may have a binding specificity to CD3. In one embodiment, D3 may have a binding specificity to CD3, D5 may have a binding specificity to HER3. In one embodiment, D3 may have a binding specificity to CD3, D4 may have a binding specificity to EGFR.

In one embodiment, the bi-specific antibody-like protein may include an amino acid sequence having at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identity to SEQ ID NO. 1 and 3; 5 and 7; 9 and 11; 13 and 15; 53 and 55; 57 and 59; 113 and 115; 117 and 119; 121 and 123; 125 and 127; 157 and 159; 297 and 299; or 199 and 201.

In one embodiment, the multi-specific antibody-like protein is tri-specific. In one embodiment, D1 may have a binding specificity to EGFR, D2 may have a binding specificity to HER3, D3 may have a binding specificity to CD3. In one embodiment, D1 may have a binding specificity to CEA, D2 may have a binding specificity to EGFR, D3 may have a binding specificity to CD3. In one embodiment, D3 may have a binding specificity to CD3, D4 may have a binding specificity to EGFR, D5 may have a binding specificity to HER3. In one embodiment, the antibody is a tri-specific antibody having the binding specificity to EGFR, HER3, and CD3. In one embodiment, the tri-specific antibody-like protein may include an amino acid sequence having at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identity to SEQ ID NO. 41 and 43; 45 and 47; 49 and 51; 101 and 103; 105 and 107; 109 and 111; 195 and 197; 137 and 139; or 161 and 163.

In one embodiment, the multi-specific antibody-like protein is tetra-specific. In one embodiment, D1 may have a binding specificity to EGFR, D2 may have a binding specificity to HER3, D3 may have a binding specificity to CD3, D4 may have a binding specificity to 4-1BB. In one embodiment, D1 may have a binding specificity to EGFR, D2 may have a binding specificity to HER3, D3 may have a binding specificity to CD3, D5 may have a binding specificity to PD-L1. the antibody is a tetra-specific antibody having the binding specificity to EGFR, HER3, CD3, and 4-1BB. the antibody is a tetra-specific antibody having the binding specificity to EGFR, HER3, CD3, and PD-L1. In one embodiment, the tetra-specific antibody-like protein may include an amino acid sequence having at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identity to SEQ ID NO. 33 and 35; 37 and 39; 141 and 143; 145 and 147; or 165 and 167.

In one embodiment, the antibody is penta-specific. In one embodiment, the antibody-like protein may have the binding specificity to EGFR, HER3, CD3, 4-1BB and PD-L1. In one embodiment, the penta-specific antibody-like protein may include an amino acid sequence having at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identity to SEQ ID NO. 17 and 19; 21 and 23; 25 and 27; 29 and 31; 69 and 71; 73 and 75; 77 and 79; 81 and 83; 85 and 87; 89 and 91; 93 and 95; 97 and 99; 129 and 131; 133 and 135; 149 and 151; 169 and 171; 173 and 175; or 177 and 179.

In a second aspect, the application provides novel sequences for complimentary determining regions (CDRs). In one embodiment, the application provides proteins, antibody-like proteins or antibodies comprising the CDRs as disclosed herein.

In one embodiment, the CDRs may have an affinity to CEA. In one embodiment, the CDRs may have an equilibrium dissociation constant (KD) to CEA, wherein the KD is not more than 0.1 nM, 2 nM, 5 nM, 10 nM, 20 nM, 30 nM or 50 nM. In one embodiment, the CDR may include an amino acid sequence having at least 80% sequence identity to SEQ ID NO. 301, 302, 303, 304, 305, or 306.

In one embodiment, the application provides a protein having an affinity to CEA. In one embodiment, the protein may have a CDR H1 having an amino acid sequence having at least 80% sequence identity to SEQ ID NO. 301. In one embodiment, the protein may have a CDR H2 having an amino acid sequence having at least 80% sequence identity to SEQ ID NO. 302. In one embodiment, the protein may have a CDR H3 having an amino acid sequence having at least 80% sequence identity to SEQ ID NO. 303. In one embodiment, the protein may have a CDR L1 having an amino acid sequence having at least 80% sequence identity to SEQ ID NO. 314. In one embodiment, the protein may have a CDR L2 having an amino acid sequence having at least 80% sequence identity to SEQ ID NO. 305. In one embodiment, the protein may have a CDR L3 having an amino acid sequence having at least 80% sequence identity to SEQ ID NO. 306. In one embodiment, the protein may include an amino acid sequence having at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% sequence identity to an amino acid sequence selected from SEQ ID NO. 279, 280, 281 or 282. In one embodiment, the protein may include an amino acid sequence having at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% sequence identity to an amino acid sequence selected from SEQ ID NO. 279, 280, 281 or 282.

In one embodiment, the application provides a multi-specific antibody-like protein having a variable region, wherein the variable region may comprise an amino acid sequence selected from SEQ ID NO. 301, 302, 303, 304, 305, or 306.

In one embodiment, the CDRs may have an affinity to CD3. In one embodiment, the CDR may have an equilibrium dissociation constant (KD) to CD3, wherein the KD is not more than 10 nM, 20 nM, 30 nM or 50 nM, 100 nM, 200 nM, 300 nM, 400 nM or 500 nM. In one embodiment, the CDR may include an amino acid sequence having at least 80% sequence identity to SEQ ID NO. 307, 308, 309, 310, 311 or 312.

In one embodiment, the protein having an affinity to CD3 includes CDR H1 having an amino acid sequence having at least 80% sequence identity to SEQ ID NO. 307. In one embodiment, the protein having an affinity to CD3 includes CDR H2 having an amino acid sequence having at least 80% sequence identity to SEQ ID NO. 308. In one embodiment, the protein having an affinity to CD3 includes CDR H3 having an amino acid sequence having at least 80% sequence identity to SEQ ID NO. 309. In one embodiment, the protein having an affinity to CD3 includes CDR L1 having an amino acid sequence having at least 80% sequence identity to SEQ ID NO. 310. In one embodiment, the protein having an affinity to CD3 includes CDR L2 having an amino acid sequence having at least 80% sequence identity to SEQ ID NO. 311. In one embodiment, the protein having an affinity to CD3 includes CDR L3 having an amino acid sequence having at least 80% sequence identity to SEQ ID NO. 312.

In one embodiment, the protein may comprise an amino acid sequence having at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% sequence identity to an amino acid sequence selected from SEQ ID NO. 227-230, 231-234, 235-238, 239-242 and 291-294. In one embodiment, the multi-specific antibody-like protein may comprise an amino acid sequence having at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% sequence identity to an amino acid sequence selected from SEQ ID NO. 227-230, 231-234, 235-238, 239-242 and 291-294.

In one embodiment, the multi-specific antibody-like protein may have a variable region wherein the variable region may comprise an amino acid sequence selected from SEQ ID 307, 308, 309, 310, 311 or 312.

In a further aspect, the application provides isolated nucleic acid sequences encoding the multi-specific antibody-like proteins, fragments, domains, regions as disclosed herein.

In a further aspect, the application provides expression vectors including the isolated nucleic acid sequences as disclosed herein.

In a further aspect, the application provides host cells including the isolated nucleic acid sequences as disclosed herein. In one embodiment, the host cell includes the expression vector as disclosed herein. In one embodiment, the host cell may be a prokaryotic cell or a eukaryotic cell.

In a further aspect, the application provides methods for producing the multi-specific antibody like proteins as disclosed herein. In one embodiment, the method includes the steps of culturing a host cell such that the DNA sequence encoding the multi-specific antibody-like protein is expressed, and purifying said multi-specific antibody. In one embodiment, the method includes the steps of culturing a host cell under conditions wherein said multi-specific antibody-like proteins are produced and recovering said antibody-like protein.

In a further aspect, the application provides immunoconjugates. In one embodiment, the immunoconjugate may include the multi-specific antibody-like proteins linked to a cytotoxic agent, an imaging agent, or both.

In a further aspect, the application provides pharmaceutical compositions. In one embodiment, the pharmaceutical composition may include the multi-specific antibody-like protein and a pharmaceutically acceptable carrier. In one embodiment, the pharmaceutical composition may further include radioisotope, radionuclide, a toxin, a therapeutic agent, a chemotherapeutic agent or a combination thereof. In one embodiment, the pharmaceutical composition may include the immunoconjugate as disclosed thereof and a pharmaceutically acceptable carrier.

In a further aspect, the application provides methods for treating or preventing a cancer, an autoimmune disease, or an infectious disease in a subject. In one embodiment, the method may include the steps of administering to the subject a pharmaceutical composition including a purified multi-specific antibody-like protein, an immunoconjugate, or a pharmaceutical composition as disclosed herein. In one embodiment, the method may further include co-administering an effective amount of a therapeutic agent. In one embodiment, the therapeutic agent may comprise an antibody, a chemotherapy agent, an enzyme, or a combination thereof.

In one embodiment, the subject is a human. In one embodiment, the subject is a mammal. In one embodiment, the subject is a chimpanzee. In one embodiment, the subject is a pet animal.

In a further aspect, the application provides a solution including an effective concentration of the multi-specific antibody-like protein, immunoconjugate, or pharmaceutical composition as disclosed herein. In one embodiment, the solution is blood plasma in a subject.

BRIEF DESCRIPTION OF THE DRAWINGS

The foregoing and other features of this disclosure will become more fully apparent from the following description and appended claims, taken in conjunction with the accompanying drawings. Understanding that these drawings depict only several embodiments arranged in accordance with the disclosure and are, therefore, not to be considered limiting of its scope, the disclosure will be described with additional specificity and detail through use of the accompanying drawings, in which:

FIG. 1 depicts the heterodimeric configuration of miniGNC molecules with five binding domains (D1-D5), of which the two monomers are encoded by Chain A (N-D1-D3/VH-CH1-CH2-CH3-D4-C) and Chain B (N-D2-D3/VL-CL-CH2-CH3-D5-C);

FIG. 2 shows the dimerization of engineered miniGNC Chain A and Chain B with knockout mutations (KO) on either VH or Fc: (2A) by Protein-A purification to fractionate the mixture into the homodimer (a), the desired heterodimer (b), and the Chain B monomer (c); and (2B) by SDS-PAGE analysis of Protein-A fractionated homodimer (a), heterodimer (b), Chain B monomer (c), and Chain A monomer (d), at the expected sizes under non-reducing and reducing conditions;

FIG. 3 shows the comparative potency of multi-specific miniGNC molecules mediated TDCC on BXPC3 tumor cells by using penta-miniGNC (SI-75P6), tetra-miniGNC (SI-75E2), tri-miniGNC (SI-75X3), bi-miniGNC (SI-75X2), and mono-miniGNC (SI-7502) molecules;

FIG. 4 shows the comparative potency of miniGNC molecules mediated TDCC on BXPC3 tumor cell line with EC50 values in the range of 0.1 to 5.5 pM;

FIG. 5 shows the survival curves of TDCC assays measuring comparative potency of (A) multi-specific miniGNC molecules with stapled domains, including penta-miniGNC (SI-68P1), tetra-miniGNC (SI-68E2 and SI-68E1), and tri-miniGNC (SI-68x2), for killing pancreatic cancer cells (HPAFII) in TDCC assay, and (B) SI-68X1 against MCF-7 breast cancer cells; and

FIG. 6 shows the functionality of multi-specific miniGNC molecules possessing a dimeric NKG2D receptor, including tri-specific (SI-49R25), tetra-specific (SI-49P_X), penta-specific (SI-49PM1 and SI-49P8) in killing breast cancer cells (MDA-MB-231) in TDCC assay.

DETAILED DESCRIPTION

In the following detailed description, reference is made to the accompanying drawings, which form a part hereof. In the drawings, similar symbols typically identify similar components, unless context dictates otherwise. The illustrative embodiments described in the detailed description, drawings, and claims are not meant to be limiting. Other embodiments may be utilized, and other changes may be made, without departing from the spirit or scope of the subject matter presented herein. It will be readily understood that the aspects of the present disclosure, as generally described herein, and illustrated in the Figures, can be arranged, substituted, combined, separated, and designed in a wide variety of different configurations, all of which are explicitly contemplated herein.

The disclosure provides, among others, isolated antibodies, methods of making such antibodies, bispecific or multi-specific molecules, antibody-drug conjugates and/or immuno-conjugates composed from such antibodies or antigen binding fragments, pharmaceutical compositions containing the antibodies, bispecific or multi-specific molecules, antibody-drug conjugates and/or immuno-conjugates, the methods for making the molecules and compositions, and the methods for treating cancer using the molecules and compositions disclosed herein.

The present application discloses multi-specific Guidance and Navigation Control (GNC) antibodies in miniature configurations (miniGNC). A miniGNC platform molecule is an assembled heterodimer of two polypeptide chains characterized by the formation of a Fab-Hinge-Fc region core structure with one, two, three, or four additional binding domains (from D1 to D5), as elucidated in FIG. 1 . The two polypeptides may be configured, for Chain A (or Chain 1): N-D1-D3(VH)-CH1-Hinge-CH2-CH3-D4-C; and for Chain B (or chain 2): N-D2-D3(VL)-CL-Hinge-CH2-CH3-D5-C. The Fc domains of the two chains are engineered to contain complementary mutations, also known as “knobs-into-holes”, to enhance the formation of the heterodimer. A miniGNC platform molecule may have variable components. For example, the VH and VL of the Fab region may be replaced by a non-Fab dimer with or without binding specificity. An additional binding domain may be an antibody fragment, such as scFv or VHH, or a non-antibody structure, such as a ligand or a receptor. A miniGNC platform antibody may be bivalent, trivalent, tetravalent, or pentavalent with up to five distinct specificities, and retains the approximate size of a normal bivalent IgG antibody (tri-miniGNC Ab at 150 kD) or slightly larger (tetra-miniGNC Ab at 175 kD, and penta-miniGNC Ab at 200 kD).

The present application relates to methods of making and using miniGNC antibodies, in particular, penta-specific miniGNC antibodies (penta-miniGNC Ab). In general, GNC proteins, such as GNC antibodies, are characterized by comprising two moieties for engaging immune cells, such as activating T cells, while targeting tumor cells. Similar to GNC antibodies, miniGNC antibodies retain multiple antigen binding domains for engaging immune cells, such as anti-CD3 for T cell activation, anti-4-1BB for co-stimulation, and anti-PD-L1 for inhibiting immune checkpoint. To improve the efficacy of antibody therapy for treating cancer, miniGNC antibodies are designed to be structurally stable and compact while retaining the characteristic feature of two moieties in GNC antibodies. This improvement allows an additional binding specificity to a second tumor associated antigen on the same or different tumor cell. As compared to GNC antibodies, miniGNC contains an Fc domain that allows for FcRn-mediated recycling and half-life extension, as well as facile protein A-based purification. The Fc receptor-mediated immunity may be incorporated if desired. An Fc-containing miniGNC antibody is quite compact, which allows for better developability and increased tumor penetration. GNC antibodies are usually larger than an IgG antibody due to increased number of antigen binding domains (AgBD), which provides spatial flexibility for binding to both a T cell and a tumor cell. On the other hand, miniGNC antibodies retains the same approximate size as human IgG antibodies calculated at approximately 110-130 kD for bi-specific; 120-160 for tri-specific; 130-190 kD for tetra-specific; 140-220 kD for penta-specific; as compared to 150 kD for human IgG. The incorporation of one or two scFvs onto each chain may reduce chain-pairing complications and improve stability while navigating through tumor microenvironment. With these characteristic features, GNC and miniGNC antibodies may be alterative of an efficacious antibody therapy for treating the same cancer, since the moiety for targeting tumor associated antigens remains the same, including but not limited to, EGFR, HER2, HER3, EGRFVIII, CD19, BCMA, CD20, CD33, CD123, CD22, CD30, ROR1, CEA, LMP1, LMP2A, Mesothelin, PSMA, EpCAM, glypican-3, gpA33, GD2, TROP2, NKG2D ligand, CD39, CLDN18.2, DLL3, HLA-G, FcRH5, GPRC5D, LIV-1, MUC1, CD138, CD70, uPAR, CD38.

The term “antibody” is used in the broadest sense and specifically covers single monoclonal antibodies (including agonist and antagonist antibodies), antibody compositions with polyepitopic specificity, as well as antibody fragments (e.g., Fab, F(ab′)₂, and Fv), so long as they exhibit the desired biological activity. In some embodiments, the antibody may be monoclonal, polyclonal, chimeric, single chain, bispecific or bi-effective, human and humanized antibodies as well as active fragments thereof. Examples of active fragments of molecules that bind to known antigens include Fab, F(ab′)₂, scFv and Fv fragments, including the products of aFab immunoglobulin expression library and epitope-binding fragments of any of the antibodies and fragments mentioned above. In some embodiments, antibody may include immunoglobulin molecules and immunologically active portions of immunoglobulin molecules, i.e. molecules that contain a binding site that immunospecifically bind an antigen. The immunoglobulin can be of any type (IgG, IgM, IgD, IgE, IgA and IgY) or class (IgG1, IgG2, IgG3, IgG4, IgA1 and IgA2) or subclasses of immunoglobulin molecule. In one embodiment, the antibody may be whole antibodies and any antigen-binding fragment derived from the whole antibodies. A typical antibody refers to heterotetrameric protein comprising typically of two heavy (H) chains and two light (L) chains. Each heavy chain is comprised of a heavy chain variable domain (abbreviated as VH) and a heavy chain constant domain. Each light chain is comprised of a light chain variable domain (abbreviated as VL) and a light chain constant domain. The VH and VL regions can be further subdivided into domains of hypervariable complementarity determining regions (CDR), and more conserved regions called framework regions (FR). Each variable domain (either VH or VL) is typically composed of three CDRs and four FRs, arranged in the following order: FR1, CDR1, FR2, CDR2, FR3, CDR3, FR4 from amino-terminus to carboxy-terminus. Within the variable regions of the light and heavy chains there are binding regions that interacts with the antigen.

The term “monoclonal antibody” as used herein refers to an antibody obtained from a population of substantially homogeneous antibodies, i.e., the individual antibodies comprising the population are identical except for possible naturally occurring mutations that may be present in minor amounts. Monoclonal antibodies are highly specific, being directed against a single antigenic site. Furthermore, in contrast to conventional (polyclonal) antibody preparations which typically include different antibodies directed against different determinants (epitopes), each monoclonal antibody is directed against a single determinant on the antigen. In addition to their specificity, the monoclonal antibodies are advantageous in that they are synthesized by the hybridoma culture, uncontaminated by other immunoglobulins. The modifier “monoclonal” indicates the character of the antibody as being obtained from a substantially homogeneous population of antibodies and is not to be construed as requiring production of the antibody by any particular method. For example, the monoclonal antibodies to be used in accordance with the present disclosure may be made by the hybridoma method first described by Kohler & Milstein, Nature, 256:495 (1975), or may be made by recombinant DNA methods (see, e.g., U.S. Pat. No. 4,816,567).

The monoclonal antibodies may include “chimeric” antibodies (immunoglobulins) in which a portion of the heavy and/or light chain is identical with or homologous to corresponding sequences in antibodies derived from a particular species or belonging to a particular antibody class or subclass, while the remainder of the chain(s) is identical with or homologous to corresponding sequences in antibodies derived from another species or belonging to another antibody class or subclass, as well as fragments of such antibodies, so long as they exhibit the desired biological activity (U.S. Pat. No. 4,816,567; and Morrison et al., Proc. Natl. Acad. Sci. USA, 81:6851-6855 [1984]).

Monoclonal antibodies can be produced using various methods including mouse hybridoma or phage display (see Siegel. Transfus. Clin. Biol. 9:15-22 (2002) for a review) or from molecular cloning of antibodies directly from primary B cells (see Tiller. New Biotechnol. 28:453-7 (2011)). In the present disclosure antibodies were created by methods of immunizing rabbits, mice, or llama in combination with subsequent strategies like hybridoma or display. Rabbits are known to create antibodies of high affinity, diversity and specificity (Weber et al. Exp. Mol. Med. 49:e305). Besides immunization of rabbits followed by B cell culture, other common strategies for antibody generation and discovery include immunization of other animals (e.g., mice, llamas) followed by hybridoma and/or display on phage, yeast, or mammalian cells; or display using synthetic variable gene libraries. This general method of antibody discovery is similar to that described in Seeber et al. PLOS One. 9:e86184 (2014).

The term “antigen- or epitope-binding portion or fragment” refers to fragments of an antibody that are capable of binding to an antigen. These fragments may be capable of the antigen-binding function and additional functions of the intact antibody. Examples of binding fragments include, but are not limited to a single-chain Fv fragment (scFv) consisting of the VL and VH domains of a single arm of an antibody connected in a single polypeptide chain by a synthetic linker or a Fab fragment which is a monovalent fragment consisting of the VL, constant light (CL), VH and constant heavy 1 (CH1) domains. Antibody fragments can be even smaller sub-fragments and can consist of domains as small as a single CDR domain, in particular the CDR3 regions from either the VL and/or VH domains (for example see Beiboer et al., J. Mol. Biol. 296:833-49 (2000)). Antibody fragments are produced using conventional methods known to those skilled in the art. The antibody fragments can be screened for utility using the same techniques employed with intact antibodies.

The “antigen- or epitope-binding fragments” can be derived from an antibody of the present disclosure by a number of art-known techniques. For example, purified monoclonal antibodies can be cleaved with an enzyme, such as pepsin, and subjected to HPLC gel filtration. The appropriate fraction containing Fab fragments can then be collected and concentrated by membrane filtration and the like. For further description of general techniques for the isolation of active fragments of antibodies, see for example, Khaw, B. A. et al. J. Nucl. Med. 23:1011-1019 (1982); Rousseaux et al. Methods Enzymology, 121:663-69, Academic Press, 1986.

Papain digestion of antibodies produces two identical antigen binding fragments, called “Fab” fragments, each with a single antigen binding site, and a residual “Fc” fragment, whose name reflects its ability to crystallize readily. Pepsin treatment yields an F(ab′)₂ fragment that has two antigen combining sites and is still capable of cross-linking antigen.

The Fab fragment may contain the constant domain of the light chain and the first constant domain (CH1) of the heavy chain. Fab′ fragments differ from Fab fragments by the addition of a few residues at the carboxy terminus of the heavy chain CH1 domain including one or more cysteines from the antibody hinge region. Fab′-SH is the designation herein for Fab′ in which the cysteine residue(s) of the constant domains bear a free thiol group. F(ab′)₂ antibody fragments originally were produced as pairs of Fab′ fragments which have hinge cysteines between them. Other, chemical couplings of antibody fragments are also known.

“Fv” is the minimum antibody fragment which contains a complete antigen recognition and binding site. This region consists of a dimer of one heavy and one light chain variable domain in tight, non-covalent association. It is in this configuration that the three CDRs of each variable domain interact to define an antigen binding site on the surface of the VH-VL dimer. Collectively, the six CDRs confer antigen binding specificity to the antibody. However, even a single variable domain (or half of an Fv comprising only three CDRs specific for an antigen) has the ability to recognize and bind antigen, although at a lower affinity than the entire binding site.

The “light chains” of antibodies (immunoglobulins) from any vertebrate species can be assigned to one of two clearly distinct types, called kappa (κ) and lambda (λ), based on the amino acid sequences of their constant domains.

Depending on the amino acid sequence of the constant domain of their heavy chains, immunoglobulins can be assigned to different classes. There are five major classes of immunoglobulins: IgA, IgD, IgE, IgG and IgM, and several of these may be further divided into subclasses (isotypes), e.g., IgG-1, IgG-2, IgG-3, and IgG-4; IgA-1 and IgA-2. The heavy chain constant domains that correspond to the different classes of immunoglobulins are called α, delta, epsilon, γ, and μ, respectively. The subunit structures and three-dimensional configurations of different classes of immunoglobulins are well known.

A “humanized antibody” refers to a type of engineered antibody having its CDRs derived from a non-human donor immunoglobulin, the remaining immunoglobulin-derived parts of the molecule being derived from one (or more) human immunoglobulin(s). In addition, framework support residues may be altered to preserve binding affinity. Methods to obtain “humanized antibodies” are well known to those skilled in the art. (see, e.g., Queen et al., Proc. Natl Acad Sci USA, 86:10029-10032 (1989), Hodgson et al., Bio/Technology, 9:421 (1991)).

The terms “polypeptide”, “peptide”, and “protein”, as used herein, are interchangeable and are defined to mean a biomolecule composed of amino acids linked by a peptide bond.

The terms “a”, “an” and “the” as used herein are defined to mean “one or more” and include the plural unless the context is inappropriate.

By “isolated” is meant a biological molecule free from at least some of the components with which it naturally occurs. “Isolated,” when used to describe the various polypeptides disclosed herein, means a polypeptide that has been identified and separated and/or recovered from a cell or cell culture from which it was expressed. Ordinarily, an isolated polypeptide will be prepared by at least one purification step. An “isolated antibody,” refers to an antibody which is substantially free of other antibodies having different antigenic a binding specificity.

“Recombinant” means the antibodies are generated using recombinant nucleic acid techniques in exogeneous host cells.

The term “antigen” refers to an entity or fragment thereof which can induce an immune response in an organism, particularly an animal, more particularly a mammal including a human. The term includes immunogens and regions thereof responsible for antigenicity or antigenic determinants.

Also, as used herein, the term “immunogenic” refers to substances which elicit or enhance the production of antibodies, T-cells or other reactive immune cells directed against an immunogenic agent and contribute to an immune response in humans or animals. An immune response occurs when an individual produces sufficient antibodies, T-cells and other reactive immune cells against administered immunogenic compositions of the present disclosure to moderate or alleviate the disorder to be treated.

“Specific binding” or “specifically binds to” or is “specific for” a particular antigen or an epitope means binding that is measurably different from a non-specific interaction. Specific binding can be measured, for example, by determining binding of a molecule compared to binding of a control molecule, which generally is a molecule of similar structure that does not have binding activity. For example, specific binding can be determined by competition with a control molecule that is similar to the target.

The term “affinity” refers to a measure of the attraction between two polypeptides, such as antibody/antigen, receptor/ligand, etc. The intrinsic attraction between two polypeptides can be expressed as the binding affinity equilibrium dissociation constant (KD) of a particular interaction. A KD binding affinity constant can be measured, e.g., by Bio-Layer Interferometry, where KD is the ratio of kdis (the dissociation rate constant) to kon (the association rate constant), as KD=kdis/kon.

Specific binding for a particular antigen or an epitope can be exhibited, for example, by an antibody having a KD for an antigen or epitope of at least about 10⁻⁴ M, at least about 10⁻⁵ M, at least about 10⁻⁶ M, at least about 10⁻⁷ M, at least about 10⁻⁸ M, at least about 10⁻⁹ M, alternatively at least about 10⁻¹⁰ M, at least about 10⁻¹¹ M, at least about 10⁻¹² M, or greater, where KD refers to the equilibrium dissociation constant of a particular antibody-antigen interaction. Typically, an antibody that specifically binds an antigen will have a KD that is 20-, 50-, 100-, 500-, 1000-, 5,000-, 10,000- or more times greater for a control molecule relative to the antigen or epitope.

Also, specific binding for a particular antigen or an epitope can be exhibited, for example, by an antibody having a KA or Ka for an antigen or epitope of at least 20-, 50-, 100-, 500-, 1000-, 5,000-, 10,000- or more times greater for the epitope relative to a control, where KA or Ka refers to an association rate of a particular antibody-antigen interaction.

“Homology” between two sequences is determined by sequence identity. If two sequences which are to be compared with each other differ in length, sequence identity preferably relates to the percentage of the nucleotide residues of the shorter sequence which are identical with the nucleotide residues of the longer sequence. Sequence identity can be determined conventionally with the use of computer programs. The deviations appearing in the comparison between a given sequence and the above-described sequences of the disclosure may be caused for instance by addition, deletion, substitution, insertion or recombination.

The present disclosure may be understood more readily by reference to the following detailed description of specific embodiments and examples included herein. Although the present disclosure has been described with reference to specific details of certain embodiments thereof, it is not intended that such details should be regarded as limitations upon the scope of the disclosure.

EXAMPLES Example 1: Configuration of Penta-Specific miniGNC Antibodies

The design of miniGNC antibodies relies on the co-expression and assembling of two polypeptide chains of a heterodimer between Chain A and Chain B (FIG. 1 ). While Chain A may be a native heavy chain (HC), Chain B is a recombinant fusion peptide between the light chain and the Fc domain of HC. At the core of this antibody structure, there is a Fab region (VH-CH1/VL-CL) followed by the hinge and Fc region (CH2-CH3/CH2-CH3) of human IgG1. “Knobs-into-holes” mutations or other complementary sets of mutations may be introduced into the CH3 domains to destabilize homodimers and favor heterodimer formation (Ridgway J B, Presta L G, Carter P., Protein Eng 1996; 9:617-21). The “hole” mutations in the CH3 domain of Chain A consist of T366S, L368A, and Y470V, while the “knob” mutation in the CH3 domain of Chain B is T366W. The “knob” created by the T366W mutation on Chain B preferentially interacts with the “hole” created by the three mutations on Chain A. This preferential pairing may further stabilize the heterodimer while the non-covalent pairing of the Fab domain components (i.e. between VH-CH1 on Chain A and VL-Ck on Chain B) creates a functional Fab region. In other words, a functional D3 binding domain, such as a functional Fab region or a non-Fab receptor dimer, can only be created in Chain A-Chain B heterodimers. As compared to GNC antibodies, miniGNC antibodies also contain antibody fragments from native IgG (Fab, Fc) and other variable-sequence based structures, such as scFv and VHH, but are engineered to preferentially configure a Fab region-Hinge-Fc region structure after the formation of a heterodimer. The characteristic feature of miniGNC antibodies is the compactness of this engineered structure.

One or more structurally diversified antigen binding domain may be added to the two N-terminals and the two C-terminals of a miniGNC molecule as D1, D2 D4, or D5, thereby creating up to five binding specificities. Each of these added binding domains may be variable-sequence-based structures, such as scFv and VHH, or non-variable sequence-based structures, such as ligand and receptor. As elucidated in FIGS. 1 , D1 and D2 refer to the binding domains linked to the N-terminals of Chain A and Chain B, respectively, whereas D4 and D5 refer to the binding domains linked to the C-terminals of Chain A and Chain B, respectively. Thus, the two polypeptides of a penta-specific miniGNC (penta-miniGNC) antibody may be configured as

Chain A: N-D1-D3(VH)-CH1-Hinge-CH2-CH3-D4-C; and

Chain B: N-D2-D3(VL)-CL-Hinge-CH2-CH3-D5-C;

where VL may be either Vλ or Vκ and CL may be either Cλ or Cκ as shown in FIG. 1 .

Depending on the number of binding domains and their binding specificities, the structural configuration of the penta-miniGNC antibody in FIG. 1 may be simplified by reducing one or more binding domains and becoming tetra-, tri-, and bi-miniGNC. For incidence, Table 1 depicts the generation and characterization of a family of anti-CD3 miniGNC antibodies for optimizing their efficacy of targeting EGFR and HER3. In this case, each binding domain exerts one binding specificity. When two of its five binding domains target the same epitope of an antigen, i.e. the same binding specificity, the penta-miniGNC antibody becomes a tetra-specific penta-miniGNC antibody.

Example 2: Engineered Core Structure of miniGNC Antibodies

To demonstrate that the configuration of miniGNC may be translated into stable and functional heterodimeric protein, a simplified asymmetric format was designed for evaluating the effect of configuration and mutations to the heterodimer formation of miniGNC molecules. Briefly, a single scFv (D1) is fused to the N-terminus of Chain A, whereas the Chain B does not have any added binding domain. In this way, the proportion of each species of dimerization between Chain A and Chain B may be distinguished by SDS-PAGE and SEC, as the predicted sizes for a Chain A homodimer (not observed), a Chain B homodimer, and a Chain A and Chain B heterodimer are 100 kDa, 150 kDa, and 125 kDa, respectively) (FIG. 2 ).

To engineer a strategy for selectively purifying the heterodimeric miniGNC molecule from a mixture, two amino acid residues in the CH3 domain (H435 and Y436) of the Chain B are substituted. In particular, the histidine (H435) is critical for the Chain B to bind to protein-A resins during the purification of therapeutic antibodies (Tustian et al., 2016), and the substitution of this amino acid or a ProA knockout mutation (ProAKO) terminates the protein-A binding. This strategy may allow separation of the heterodimer via selective elution from a protein-A column. As the protein-A column retains the heterodimer through its parental heavy chain binding site, the Chain B homodimer flows through as the Chain B lacks protein-A binding. The design of a ProAKO on the Chain B minimizes any possible issue of altering immunogenicity by amino acid substitutions of the protein-A binding site with residues taken from the homologous region in the IgG3 subclass. Although most of miniGNC molecules will predominantly incorporate the structure and sequence of IgG1 subtype, IgG3 has an overall similar structure to other IgG subclasses with some specific structural perturbations in binding to protein-A, protein-G and FcRn (neonatal Fc receptor). This difference is based on Fc sequence difference as revealed earlier where the presence of R435 (H435 in other subtypes) in IgG3 ablates its Fc interaction with protein-A. Hence, in representative miniGNC molecules, amino acids critical for protein-A binding on miniGNC Chain B (H435 and F436) have been mutated to the IgG3 counterpart sequences (R435 and Y436).

In the class of multi-specific miniGNC antibodies with an addition of scFv fused to the N terminal of Chain B, the interaction to protein-A binding is still possible if the scFv comes from VH3 family. VH3 encoded antibodies are known to interact with Staphylococcal Protein A (SPA) and residues in FR1, CDR2 and FR3 have been identified to be involved in SPA binding (Roben, et al., 1995), and structural data indicated that the replacement of a single involved region with the corresponding region from the nonbinding immunoglobulin ablates protein-A binding by VH3 encoded antibodies. Substitution of the amino acid R19 in FR1 was identified to be critical in binding to protein-A and was undertaken with the amino acid sequence (S19) from equivalent region in the VH4 family.

Four sets of miniGNC molecules (SEQ ID 1-16) with four different versions of chain B mutations (SEQ ID 3, 7, 11 and 15) embracing different combinations of ProAKO: H435R/Y436F (Fc) and R19S (VH) were purified and analyzed with analytical size exclusion chromatography. Only protein containing Chain B with both sets of mutations allowed complete removal of Chain B contaminants (FIG. 2A). This VH3 protein A knockout mutation (R19S) together with Fc ProteinA knockout mutations (H435R, F436Y) on Chain B was incorporated in most of the multi-specific antibody formats and used to produce bi-, tri-, tetra- and penta-miniGNC molecules.

To demonstrate the feasibility of generating functional miniGNC proteins with alternative antibody isotypes, an example miniGNC containing IgG4 constant regions was generated. SI-75XM9 (SEQ ID 297-300) is analogous to SI-75X5 (SEQ ID 1-4) bispecific miniGNC, except that the IgG1 CH1, hinge, and Fc were replaced with IgG4 CH1, hinge, and Fc. Notably, both proteins have the same binding domains (anti-HER3 domain in D2 and anti-CD3* domain in D3) and contain the same core structure and mutations (Knobs-into-Holes Fc mutation; R19S in anti-HER3 scFv; and H435R/Y436F mutations in Fc). As shown in Table 8, SI-75XM9 had comparable titer to SI-77X5, and had a significant 19% increase in the percent protein of interest (85.6% POI vs. 72.2% POI) after protein A purification, as assessed by analytical SEC. The reduction in high molecular weight species could be related to the shorter hinge length of IgG4 (12 amino acids instead of 15), which could reduce the propensity for association of higher-order oligomers. Thus, generation of miniGNC proteins with alternative antibody isotypes is not only possible, but can lead to more favorable properties such as decreased aggregation.

Example 3: Configuration of Multi-Specific miniGNC Antibodies

To generate and characterize the first group of multi-specific miniGNC antibodies, a trio of moiety 1 binding domains, i.e. αCD3, αPD-L1, and α4-1BB, and two moiety 2 binding domains against EGFR and HER3, respectively, were selected for comparison. As shown in Table 1, the group was subdivided into penta-miniGNC, tetra-miniGNC, tri-miniGNC, and bi-miniGNC groups. Of each subgroup, there was at least one miniGNC antibody having the CD3 binding from D3. The penta-miniGNC group includes SI-75P6 (SEQ ID 17, 19, with αEGFR from D3 position), SI-75P4 (SEQ ID 21, 23, with 41BBL, the ligand to 4-1BB receptor, at D4), SI-75P3 (SEQ ID 25, 27), and SI-75P9 (SEQ ID 29, 31, with αHER3 from D3). The tetra-miniGNC group have two antibodies, SI-75E1 (SEQ ID 33, 35) and SI-75E2 (SEQ ID 37, 39) comparing the effect in the presence and absence of either α4-1BB or αPD-L1 domain. The tri-miniGNC group have three antibodies, SI-75X3 (SEQ ID 41, 43), SI-75X16 (SEQ ID 45, 47), and SI-75X18 (SEQ ID 49, 51) for comparing the two moiety 2 binding domains on either N- or C-terminus of the heterodimer. The bi-miniGNC group have three antibodies, SI-75X1 (SEQ ID 53, 55), SI-75X2 (SEQ ID 57, 59), and SI-75X5 (SEQ ID 1, 3), each of which has one moiety 1 binding domain and one moiety 2 binding domain.

The DNA encoding each member of the first group of miniGNC antibodies were cloned into vector pTT5, which were expressed with acceptable titers using ExpiCHO expression systems for 9 days. The miniGNC antibodies were purified with 5 mL MabSelect protein-A columns followed by Size Exclusion using a highload 16/600 200 pg preparative SEC column on either an Akta Avant or Purifier system. SEC aggregates were analyzed using a waters HPLC linked to multi angle light scattering (MALS, Wyatt systems) to identify correct molecular weight by do/dc calculated methods.

Example 4: Octet Analysis of Binding Affinity

To assess the functionality of miniGNC antibodies, the binding affinity of each domain was determined by using Biolayer Interferometry (Octet 384 system). Octet analysis was used to ensure that the selected miniGNC antibody retains the binding specificity and affinity to all their cognate antigens. Each miniGNC antibody was loaded onto AHC sensors for 180 seconds at 10 ug/ml, followed by a 60-second baseline step, a 180-second association step with 100 nM of commercially purchased human antigen, and a 360-second dissociation step. Samples for all steps were in Octet buffer (PBS containing 0.1% Tween 20 and 1% BSA). Fits were performed using a 1:1 binding model to extract affinity KD values. As shown in Table 1, the binding affinity for each binding domain, as measured by its KD, varies within an acceptable range. For moiety 1 binding, the KD for αCD3 domain may vary between 17.4 and 36.2 nM, for αPD-L1 between 1 and 2.72 nM, and for α4-1BB between 7.51 and 37.3 nM; and for moiety 2 binding, the KD for αEGFR varies between 5.56 and 11.1, and for αHER3 between 112.8 and 185 nM.

Example 5: Comparative Potency of Multi-Specific miniGNC Antibodies

The first group of multi-specific miniGNC antibodies was subjected to T-cell dependent cellular cytotoxicity (TDCC) assay for measuring the potency for killing cancer cells. With an αCD3 binding domain in all molecules, this group of miniGNC antibodies was equipped to engage T cells, redirect T-cell mediated cytolysis, and ultimately kill target cells.

A luminescence-based T-cell dependent cellular cytotoxicity (TDCC) assay was used to measure the extent of antibody-induced cellular cytotoxicity by quantification of cell viability via constitutive expression of luciferase. Luciferised BXPC3 human pancreatic cancer cell lines (ATCC, Manassas, Va.) were cultured at 37° C., 5% CO2 in RPMI (ATCC, Manassas, Va.) medium with 10% heat-inactivated fetal bovine serum (Invitrogen, Waltham, Mass.). Cell viability was monitored with a Vi-CELL automated cell counter (Beckman Coulter, Pasadena, Calif.). Target cell surface expression was measured by flow cytometry. Human pancreatic cancer cells, BXPC3 cells, were co-cultured with human pan T-cells at an effector-to-target (E:T) ratio of 5:1 and antibodies were added with a 5-fold dilution series (0-30 nM). Using a Multidrop bulk liquid dispenser (BIOTEK, Winooski, Vt.), 500 cells per well of target cells (20 μL per well) and 25,00 cells per well of T-cells (20 μL/well) were plated sequentially into 384-well, white, flat-bottom, polystyrene TC-treated microplates (Corning, Corning, N.Y.). Antibody dilutions were added (10 μL/well) and plates were incubated for 72 hrs at 37° C., 5% CO2 before luminescence-based cell viability quantification. 20 ul of Bright-Glo (Promega) was added to wells, and luminescence corresponding to viability of tumor cells was determined using a CLARIOstar plate reader.

Data were fit to a sigmoidal function to calculate and list EC50 values in Table 1 for comparison. FIG. 3 shows the dose-dependent cell viability curves of miniGNC antibodies selected from a penta-miniGNC (SI-75P6), a tetra-miniGNC (SI-75E2), a tri-miniGNC (SI-75X3), a bi-miniGNC (SI-75X2), and a mono-miniGNC (SI-7502) molecule. While all multi-specific miniGNC antibodies were capable of killing BXPC3 cells completely, both pent- and tetra-miniGNC antibodies steadily displayed high potency in the range of EC50 in pM. In this regard, SI-75X1 was exceptionally potent. The data demonstrate the important roles of moiety 1 binding domains, in particular, the αPD-L1 domain as an immune checkpoint inhibitor when targeting BXPC3 cancer cells.

Example 6: Configuration of CD3 Binding Domain in miniGNC Antibodies

By definition, a miniGNC antibody is capable of interfacing with at least one immune effector cell and one target cancer cell through the binding of its moiety 1 and 2 binding domains, respectively. Using the general scheme of miniGNC antibody configuration (FIG. 1 ), it is possible that assigning two moiety 2 binding domains to D1 and D2 may lead to different efficacy from assigning them to D1 and D4 or D2 and D5 because the relative position of the targets on the cell surface is different, either on the top and bottom or on both sides. In this context, a second group of penta-miniGNC antibodies were configured and listed in Table 2. This group of minGNC antibodies share the same binding specificities to CD3, CD19, EGFR, 4-1BB, and PD-L1, and the same binding domains at D2, D4, and D5. SI-68P13 (SEQ ID 69, 71) has αCD3 D3 domain, which is comparable to SI-75P3 of the first group except the difference in D2, i.e. αCD19 vs. αHER3, and to SI-68P17 (SEQ ID 73, 75) of the second group except the switch of αCD3 domain to D1. The rest of the second group of miniGNC antibodies share the same binding specificities from D1 (αCD3) and D3 (αEGFR). SI-68P17 (with the binding specificity to CD19, 4-1BB and PD-L1, respectively.

Anti-CD3 antibody plays a central role in T cell activation based immune therapy. Humanized antibody is desirable for the development of a therapeutic antibody. CD3 domain was incorporated into positions D1 and D3 to generate SI-68P17 (SEQ ID 73, 75) and SI-68P13 (SEQ ID 69, 71) for testing positional effect. The anti-CD3 sequences in humanized framework 1 (CD3**), 2 (CD3***) 3 (CD****) and 4 (CD*****) were cloned into an expression cassette for producing SI-68P15 (SEQ ID NO. 77, 79), SI-68P18 (SEQ ID 81, 83), SI-68P19 (SEQ ID 85, 87), and SI-68P16 (SEQ ID 89, 91) (Table 2). Each expression cassette was transfected into 25 mL of ExpiCHO and expressed for 8 days followed by protein-A affinity chromatography for harvesting and purifying each penta-miniGNC antibody. The antibodies were produced with good titer (Table 2). Octet was used to verify that the penta-miniGNC antibodies containing different CD3 domains, can bind to human CD3, respectively (Table 2). Each penta-miniGNC antibody was loaded via AHC sensors at 10 μg/ml and bound to a serial dilution (highest 200 nM, 1:2.5 dilutions) or a single 100-nM concentration of His-tagged human CD3. The resulting global fit to a 1:1 binding model demonstrated that the penta-GNC antibodies bind to CD3 with affinities in the low nanomolar range (Table 2).

To evaluate the effect of CD3-mediated T cell directed cytotoxicity on cancer cells, BXPC3 tumor cell line was used as target. Serial dilutions (0 to 30 nM; 1 to 5 dilution factor) of antibodies were added to a white 384-well plate containing luciferized target cells and activated T cells (plated immediately before drug; effector:target=5:1) in a total volume of 50 ul. After an additional 72 hours, 20 ul of Bright-Glo (Promega) was added to wells, and luminescence corresponding to viability of luciferized tumor cells was determined using a CLARIOstar plate reader. Data were fit to a sigmoidal function to calculate EC50 values, which were in the range of 0.1 to 5.5 pM as shown by FIG. 4 and listed in Table 2. The data demonstrate that there are certain degrees of flexibility in anti-CD3 positioning, configuration, and binding affinity.

Example 7. Multi-Specific miniGNC Antibodies Having VHH as Binding Domains

To multi-specific antibody platforms, such as GNC and miniGNC antibodies that contain multiple scFv domains, a potential issue is related to chain mispairing due to multiple VH and VL domains in the same molecule. Different VH and VL domains have different propensities to interact with each other. If binding domains of different specificity have superior interaction energy, then the wrong pairings may form when the protein assembles. As a result, none of the binding domains will bind their targeted antigens.

VHH refers to “antibodies” with single Ig domains, i.e. “heavy chain only”, also known as a single-domain antibody (sdAb) or a nanobody. The first single-domain antibodies were engineered from heavy-chain antibodies found in camelids, also known as V_(H)H fragment (VHH).

VHH domains have been increasingly incorporated into antibody-based therapeutics due to several favorable properties. VHH domains may have increased stability and solubility compared to more traditionally used scFv domains. Whereas the VH/VL interface of traditional antibody variable regions is hydrophobic, the transient exposure of these surfaces can result in significant aggregation or precipitation. On the other hand, VHH domains have a naturally more hydrophilic surface and therefore can have superior solubility and stability properties. An obvious benefit of VHH domains over Fab or scFv domains is their small size. Where Fab domains are about 50 kDa and scFv domains are about 25 kDa, VHH domains are a very compact 12-15 kDa. The penta-miniGNC antibodies contain five binding domains (FIG. 1 ). Incorporation of VHH domains instead of scFv domains may significantly decrease molecular size, and increase tumor penetration.

A third group of multi-specific miniGNC antibodies were created and configured to have VHH binding domains against EGFR and HER3 (Gottlin et al., 2009; Eliseev et al., 2018) (Table 3). Penta, Tri, and bi specific single domain variable regions (VHH)-incorporated miniGNC molecules were constructed and purified with reasonable titer. Binding activity of each domain of multi-specific miniGNCs: SI-75P5 (SEQ ID 93, 95), SI-75P8 (SEQ ID 97, 99), SI-75X4 (SEQ ID 101,103), SI-75X17 (SEQ ID 105, 107), SI-75X19 (SEQ ID 109, 111), SI-75X9 (SEQ ID 113-115), SI-75X11 (SEQ ID 117,119), SI-75X15 (SEQ ID 121,123) and SI-75X13 (SEQ ID 125, 127) were verified using Octet. AHC sensors were used to capture the GNC antibody at a concentration of 10 ug/ml for 180 seconds. After a 60-second baseline step, a single concentration of antigen was used for a 180-second association step. Antigens tested include 200 nM human EGFR (purified in-house), 100 nM human CD3 (Acro CDD-H52W1), 20 nM human PD-L1 (Acro PD1-H5229), 400 nM human 4-1BB (purified in-house), 200 nM human HER3 (Acro ER3-H5223). After association, a 420-second dissociation step was used. The tabulated K_(D) values were calculated using a one-to-one binding model in ForteBio Data Analysis software version 11. The data demonstrated that all domains retained high affinity in the VHH-incorporated miniGNC platform.

T cell directed cytotoxicity on cancer cells, BXPC3 tumor Cell line was used as target. Serial dilutions (0 to 30 nM; 1 to 5 dilution factor) of antibodies were added to a white 384-well plate containing luciferized target cells and activated T cells (plated immediately before drug; effector:target=5:1) in a total volume of 50 ul. After an additional 72 hours, 20 ul of Bright-Glo (Promega) was added to wells, and luminescence corresponding to viability of luciferized tumor cells was determined using a CLARIOstar plate reader. EC50 values are tabulated in Table 3.

Example 8. Engineered Fab (D3) Domain for Improved Expression and Protein Quality

A disulphide staple was optionally introduced in the VH-VL interface of the fab region (FIG. 5 ). The purpose of this engineering was improving heterodimer pairing and stabilize the overall structure by the formation of a covalent disulphide bond (Weatherill et al., 2012) at the core-fab interface. Cysteines pair was optionally introduced to form disulphide bond at V_(L)A100 on Chain B and its corresponding V_(H)A44 on Chain A fab region.

A pair of penta-miniGNC antibodies (SI-38P11 and SI-76PM1) (SEQ ID NO. 129 and 131; 133 and 135) with identical binding specificities were created for analysing the effect of stapled variable region in the Fab. The Chain A of the two antibodies comprises αCD20 scFv at D1, αCD3 VH at D3 (VH Fab-CH1-Fc), and α4-1BB at D4, whereas Chain B comprises αCD19 at D2, αCD3V_(L) at D3 (VKappa Fab CL-Fc) and αPD-L1 scFv at D5 (Table 4) according to the naming system in FIG. 1 . SI-76PM1 was constructed with an additional disulphide in the D3 (VH/VL Fab-CH1/CL-Fc) and SI-38P11 was constructed without any additional disulphide pairing in the VH/VL fab.

Penta-miniGNC antibody constructs with and without the disulphide staple at position D3 were expressed in ExpiCHO system. Construct with stapled D3 (SI-76PM1) was produced with significantly higher titer than SI-38P11. Both proteins were purified with 5 mL MabSelect protein A columns followed by Size Exclusion using a hiload 16/600 200 pg preparative SEC column on either an Akta Avant or Akta Pure Purifier system. SEC aggregates were analyzed using a waters HPLC linked to multi angle light scattering (MALS, Wyatt systems) to identify correct molecular weight by do/dc calculated methods. With all of the analyses conducted as shown in Table 4, the disulfide bonded, i.e. “D3 stapled Fab”, penta-miniGNC antibodies displayed 5% higher protein of interest production. Both molecules exhibited comparable antigen binding kinetics (Table 4).

Example 9. Multi-Specific miniGNC Antibodies with Stapled scFv Binding Domains

The core structure of multi-specific miniGNC molecules were engineered to acquire several features in order to stabilize the heterodimer, including the covalently linked hinge and non-covalent and preferential interaction of “knobs-into-holes” by the CH3 domains in Fc region. While the stability and compactness are desirable, it remains unclear whether the closer proximity of D1 and D2 or D3 and D4 may affect their stability and independent function. To maintain the stability and independence of each added binding domains, one option is to introduce a disulfide bond at V_(L)100 and V_(H)44 in each scFv domain, i.e. to staple each scFv domain. A disulfide bond between V_(L) and V_(H) may be used for all scFv domains to stabilize the overall structure. Alternatively, a disulphide bond may be introduced into at least one selected scFv domain at any position.

Four miniGNC antibodies have their D1 and D2 targeting EGFR and HER3 were grouped for measuring comparative potency of TDCC to the pancreatic cancer cells (HPAF-II), including tri-miniGNC (SI-68X2, SEQ ID NO. 137,139), tetra-miniGNC (SI-68E1, SEQ ID NO, 141, 143, and SI-68E2, SEQ ID NO. 145, 147), and penta-miniGNC (SI-68P1, SEQ ID NO. 149, 151) molecules. The moiety 1 binding specificities to 4-1BB and PD-L1 were the variable, whereas CD3 was the constant as D3 in the group interms of multispecificity. The expression construct encoding each of these four miniGNC antibodies was modified such that all scFv domains carrying a disulfide bond. The constructs were expressed individually in ExpiCHO system and each antibody was purified with reasonable titer. The binding kinetics to respective antigens were verified using Octet. AHC sensors were used to capture the miniGNC antibody at a concentration of 10 ug/ml for 180 seconds. After a 60-second baseline step, a single concentration of antigen was used for a 180-second association step. Antigens tested included 200 nM human EGFR (purified in-house), 100 nM human CD3 (Acro CDD-H52W1), 20 nM human PD-L1 (Acro PD1-H5229), 400 nM human 4-1BB (purified in-house), 200 nM human HER3 (Acro ER3-H5223). After association, a 420-second dissociation step was used. The tabulated K_(D) values were calculated using a one-to-one binding model in ForteBio Data Analysis software version 11. Analysed KD values for each miniGNC molecule with all stapled scFv domains, as shown in Table 5, were compared with KDs of monoclonal antibody controls for respective antigens as shown in Table 6. The binding kinetics data shows comparable binding affinity of each stapled scFv domain with its respective mAb or Fc-scFv control SI-1C3 (SEQ ID 181, 183) SI-1C7 (SEQ ID 185), SI-9C21 (SEQ ID 187, 189), SI-35SF11 (SEQ ID 191), SI-3SF11 (SEQ ID 193), SI-20C14 (SEQ ID 287 and 289) (Table 6), suggesting that stapling one or more scFv domains seems to have little effect to the binding affinity.

To evaluate the effect of stapled scFv domains to the potency of the miniGNC antibody, T cell directed cytotoxicity (TDCC) assay was used and the target cells were HPAF-II, human a human pancreatic cancer cell line (ATCC, Manassas, Va.). The surface expression of the target cells was validated by flow cytometry. Serial dilutions (0 to 30 nM; 1 to 5 dilution factor) of antibodies were added to a white 384-well plate containing target cells and activated T cells (plated immediately before drug; effector:target=5:1) in a total volume of 50 ul. After an additional 72 hours, 20 ul of Bright-Glo (Promega) was added to wells, and luminescence corresponding to viability of luciferised tumor cells was determined using a CLARIOstar plate reader. Data were fit to a sigmoidal function to calculate EC50 values. As shown in FIG. 6 and Table 5, the survival curves revealed that the potency of all four miniGNC antibodies was be within the dose range of pM and with a tendency of the penta-miniGNC antibody exerting higher TDCC potency than that of tetra-miniGNC and tri-miniGNC antibodies. This observation again shows little effect by using stapled scFv domains.

Example 10. miniGNC Having NKG2D Receptor Dimer as a Binding Domain

An increased number of binding specificities allows the GNC antibodies to bind not only T cells but also subsets of T cells, natural killer cells, and other types of immune cells, collectively known as moiety 1 binding domains/specificities (see Applicant's applications, WO/2019/005641 and WO2019191120, incorporated herein in its entirety). Some of moiety 1 binding specificities may replace the cellular response to or recognition of targeted cells. For example, NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells, as its ligands are induced during cellular stress, either as a result of viral infection or genomic stress, such as in cancer. In humans, NKG2D is expressed by NK cells, cells, and CD8+ T cells. The addition of NKG2D as a binding domain/specificity to the class of miniGNC antibodies may improve the cytotoxicity and efficacy of the antibody as a single multi-functional therapeutic agent.

In NK cells, NKG2D serves as an activating receptor, which itself can trigger cytotoxicity, whereas on CD8⁺ T cells the function of NKG2D is to send co-stimulatory signals to activate them. NKG2D forms a homodimer whose ectodomains serve for ligand binding. This feature qualifies NKG2D as a non-variable-sequence-based binding domain in a miniGNC format and other binding domains can be added to create a class of multi-specific NKG2D-miniGNC protein. In one miniGNC format, individual NKG2D monomer was incorporated in the D3 position on chain A and chain B which formed a dimeric NKG2D receptor on Fc dimerization. Thus, NKG2D can act as a receptor for the multi-specific miniGNC molecule to bind its ligand. In other miniGNC format, a NKG2D tandem repeat was designed by adding a (GxSy)n spacer/linker between individual NKG2D monomers which homodimerizes and forms a functional dimeric receptor. This NKG2D tandem dimeric structure can be positioned in D1, D2, D4 or D5.

As listed in Table 7, this class includes mono-NKG2D-miniGNC (SI-49R26, SEQ ID NO. 153, 155), bi-miniGNC (SI-49R27, SEQ ID NO. 157, 159), tri-miniGNC (SI-49R25, SEQ ID NO. 161, 163), tetra-miniGNC (SI-49P_X, SEQ ID NO. 165, 167), and penta-mini-GNC molecules (SI49P8, SI-49P9, SEQ ID. NO. 169, 171, 177, and 179). A control penta-miniGNC, SI-49PM1 (SEQ ID NO. 173, 175), was created by switching the positions of D1 (αCD3) and D3 of SI-49P8, and the Octet binding affinity for either NKG2D or CD3 was not affected by this switch. While the binding affinity of other moiety 1 binding domains remained stable in this class of NKG2D-miniGNC molecules, the binding affinity of NKG2D was within 2-fold. Thus, the penta-miniGNC molecule possesses the binding function of NKG2D receptor for binding to NKG2D ligand.

To assess and compare the potency of TDCC of NKG2D-miniGNC molecules, tri-, tetra-, and penta-miniGNC molecules, SI-49R25, SI-49P_X, and SI-49P8 and SI-49PM1 were used to target MDA-MB-231 breast cancer cell line. Serial dilutions (0 to 30 nM; 1 to 5 dilution factor) of the miniGNC protein were added to a white 384-well plate containing luciferised MDA-MB-231 cells 24 hours prior and grown at 37° C. Activated T cells were plated immediately before miniGNC molecules (effector:target=15:1) in a total volume of 50 ul. After incubated for additional 72 hours, 20 ul of Bright-Glo (Promega) was added to wells, and the luminescence corresponding to viability of luciferised tumor cells was determined using a CLARIOstar plate reader. Data were fit to a sigmoidal function to calculate EC50 values (FIG. 7 ). Based on the dose-viability curves, there were two groups, the tetra- and penta-miniGNC molecules were more potent than the tri-miniGNC molecule, SI-49R25. As listed in Table 7, the difference might result from the addition of αPD-L1. However, the EC50 value (59.3 nM) of SI-49R25 should be considered as relatively potent. To the breast cancer cell line MDA-MB-231, CD19, which is a pan-B cell marker, is a non-participating tumor antigen. In this regard, SI-49R25 may be viewed as having two binding specificities to CD3 and NKG2D ligand. Thus, the data indicates that the incorporation of NKG2D receptor to different miniGNC antibody format contributes to the potency of TDCC. In a broader sense, the miniGNC antibody molecules can accommodate multiple binding specificities to modulate, cooperate, and direct an optimized immune response to targeted cells, such as cancer.

TABLES

TABLE 1 The configuration, production, binding affinity, and potency of multi-specific minGNC molecules when targeting EGFR and/or HER3-expressing pancreatic cancer cells (BXPC3). Protein D1/KD D2/KD D3/KD D4/KD D5/KD Titer EC50 ID (nM) (nM) (nM) (nM) (nM) (μg/ml (pM) Penta-miniGNC SI-75P6 αCD3 αHER3 αEGFR α4-1BB αPDL-1 96.5 0.011 36.2  138  5.56 37.3 1.45 SI-75P4 αEGFR αHER3 αCD3 α4-1BBL αPDL-1 48.4 0.102 10.4  150 22.7 115   2.72 SI-75P3 αEGFR αHER3 αCD3 α4-1BB αPDL-1 39.4 1.300 8.91 158 17.4  7.51 1   SI-75P9 αEGFR αCD3 αHER3 α4-1BB αPDL-1 30 0.160 11.1    20.1 140   21.2 2.7  Tetra-miniGNC SI-75E1 αEGFR αHER3 αCD3 α4-1BB — 30.2 5.800 8.9  185 20.3 17.8 — SI-75E2 αEGFR αHER3 αCD3 — αPDL-1 172.3 0.085 8.24 114 22.1 — 1.36 Tri-miniGNC SI-75X3 αEGFR αHER3 αCD3 193.5 5417 8.47 146 18.2 — — SI-75X16 αEGFR αHER3 αCD3* 183.5 95540 6.8    112.8 33.4 — — SI-75X18 αCD3* αEGFR αHER3 38.2 6090 47.3  2.72 93.75  Bi-miniGNC SI-75X1 αEGFR αCD3 246.1 0.71 8.11 24   — — SI-75X2 αHER3 αCD3 237.7 433.8 162 27.8 — — SI-75X5 αHER3 αCD3* 192.9 9.095   139.2 44.4 — —

TABLE 2 The effect of the position and binding affinity of the CD3 binding domain on the potency of penta-minGNC molecules when targeting EGFR-expressing pancreatic cancer cells (BXPC3). Protein D1/KD D2/KD D3/KD D4/KD D5/KD Titer EC50 ID (nM) (nM) (nM) (nM) (nM) (μg/ml) (pM) SI-68P13 αEGFR αCD19 αCD3 α4-1BB αPD-L1 35.1 0.09  5.64 4.33 25.9  14.8 1.04 SI-68P17 αCD3 αCD19 αEGFR α4-1BB αPD-L1 40 0.6 15.82 5.05 5.38 26.8 2.72 SI-68P15 αCD3** αCD19 αEGFR α4-1BB αPD-L1 58.1 0.16 22.4  2.85 2.42 17.1 0.4  SI-68P18 αCD3*** αCD19 αEGFR α4-1BB αPD-L1 26 0.19 14.46 1.35 8.18  7.51 1.00 SI-68P19 αCD3**** αCD19 αEGFR α4-1BB αPD-L1 28 0.12 16.74 3.44 4.43 21.2 0.7  SI-68P16 αCD3***** αCD19 αEGFR α4-1BB αPD-L1 72 5.5 60.6  2.55 2.41 23.3 0.5 

TABLE 3 The effect of VHH single binding domain(s) on the potency of multi- specific minGNC molecules when targeting BXPC3 tumor cells Protein D1/KD D2/KD D3/KD D4/KD D5/KD Titer EC50 ID (nM) (nM) (nM) (nM) (nM) (μg/ml) (pM) SI-75P5 αEGFR VHH αHER3 VHH αCD3 α4-1BB αPD-L1 200.5 443 23.5 4.68 26.1 23.3  3.25 SI-75P8 αEGFR VHH αHER3 VHH αCD3* αEGFR αHER3 295 967468000  6.22  0.786 44.1  6.22  0.786 SI-75X4 αEGFR VHH αHER3 VHH αCD3 — — 65.8 5766 51.5 7.68 26.3 — — SI-75X17 αEGFR VHH αHER3 VHH αCD3* — — 330 No killing 14.8 4.58 68   — — SI-75X19 — — αCD3* αEGFR VHH αHER3 VHH 223.4 1873 64.4 20.6 10.52 SI-75X9 — αHER3 VHH αCD3* — — 234 2584 — 3.86 84.2 — — SI-75X11 αEGFR VHH — αCD3* — — 214 564 21.6 — 65.7 — — SI-75X15 — — αCD3* — αHER3 VHH 161.3 27400 —  38.08 — 13.7  SI-75X13 — — αCD3* αEGFR VHH — 165.6 4858 — 56   34−  —

TABLE 4 The effect of “stapled” CD3 binding domain at D3 position on the production of multi-specific miniGNC molecules. D3 D1/KD D2/KD (Stapled)/ D4/KD D5/KD Protein (nM) (nM) KD (nM) (nM) (nM) Titer ID αCD20 αCD19 αCD3 α4-1BB αPD-L1 (μg/ml) % POI SI-38P11 7.33 1.89 5.23 (No)  14.8 1.1 80 69 SI-76PM1 6.09 3.30 3.22 (Yes) 22.43 1.47 129 75

TABLE 5 Comparative potency of multi-specific miniGNC molecules with “stapled” scFv at all positions when targeting tumor cells. D1 D2 D4 D5 (Stapled)/ (Stapled)/ D3/KD (Stapled)/ (Stapled)/ EC50 Protein KD (nM) KD (nM) (nM) KD (nM) KD (nM) Titer (pM) ID αEGFR* αHER3 αCD3 α4-1BB αPD-L1 (μg/ml) HPAF-II SI-68X2 <0.001 114.4 24.3 — — 88.9 6.6 SI-68E1 <0.001 138.8 26.2 12.7 — 114.8 3.6 SI-68E2 <0.001 120 28.4 — 0.4 67 1.3 SI-68P1 <0.001 93.4 24.3  9.8 0.6 87.1  1.02 αCEA αEGFR* αCD3 MCF-7 SI-68X1 <0.001 <0.001 14.3 — — 69 4.2 αHER2 — αCD3 SI-68X3 NA NA 57 NA

TABLE 6 Characterization of the unstapled versions of each domain (D1-D5) in mAb or scFv format to respective antigens. Protein Unstapled Domain Titer KD ID Controls Structure (μg/ml) (nM) SI-1C3 D1 = αEGFR* mAb 44.9 <0.001 SI-1C7 D2 = αHER3 Fc-scFv 290.7 136.5 SI-9C21 D3 = αCD3 mAb 252.1 26.3 SI-35FS11 D4 = α4-1BB Fc-ScFv 7.67 14.9 SI-3FS11 D5 = αPD-L1 Fc-ScFv 18 0.94 SI-20C14 D1 = αCEA mAb NA <0.001

TABLE 7 The characterization of multi-specific minGNC molecules with NKG2D receptor dimer incorporated in miniGNC format and potency of tri, tetra and penta molecules in killing MDA-MB-231 tumor cells Protein D1/KD D2/KD D3/KD D4/KD D5/KD Titer EC50 ID (nM) (nM) (nM) (nM) (nM) (μg/ml) (pM) SI-49R26 — — NKG2D — — 28 n.a. — —   17.7− — — SI-49R27 αCD3 — NKG2D — — 38.6 n.a. 32.2  — 16   — — SI-49R25 αCD3 αCD19 NKG2D — — 50 59330    34.50 7.62  12.80 — — SI-49P_X αCD3 αCD19 NKG2D — αPD-L1 8.8 119.5 30.45 1.31 10.4 — 0.2  SI-49P8 αCD3 αCD19 NKG2D α4-1BB αPD-L1 62.3 570.3 36.3  2.98 24.3 7.71 1.08 SI-49PM1 NKG2D αCD19 αCD3 α4-1BB αPD-L1 30.3 946.5 24.49 5.5  30.2 2.74 2.23 SI-49P9 αCD3 αCD19 NKG2D 41BBL αPD-L1 28.9 n.a. 29.80 6.4  27.2 112    2.01

TABLE 8 The characterization of bispecific miniGNC molecules with different IgG subtypes in the Fc domain. IgG Titer Protein subtype D1 D2 D3 D4 D5 (μg/ml) % POI SI-75X5 IgG1 — αHER3 αCD3* — — 192.9 72.2 SI-75XM9 IgG4 — αHER3 αCD3* — — 150.5 85.6

TABLE 9 Annotation of binding domains for their binding specificity, domain structure, origin, and sequence identification number (SEQ ID). Binding Structure in SEQ Target Domain miniGNC Origin ID NO. CD20 Ritu scFv Rituximab 259-262 EGFR EGFR scFv and Fab αEGFR H7 203-206 EGFR EGFR* scFv Panitumumab 207-210 HER3 MM-111 scFv and Fab MM-111 255-258 CD3 αCD3 scFv and Fab 284A10 219-222 CD3 αCD3* scFv and Fab 283E3BSM 227-230 CD3 αCD3** scFv 284A10 FR 1 231-234 CD3 αCD3*** scFv 284A10 FR 2 235-238 CD3 αCD3**** scFv 284A10 FR 3 239-242 CD3 αCD3***** scFv 283E3FRS 291-294 PD-L1 αPD-L1 scFv PL221G5 243-246 4-1BB α4-1BB scFv 466F6 247-250 NKG2D NKG2D Receptor 253-254 Ligand 4-1BB 41BBL Ligand 251-252 EGFR αEGFR VHH VHH VHH-122 263-264 HER3 αHER3 VHH VHH VHH BCD090-M2 265-266 CD19 huBU12 scFv SI-huBU12-H4, 215-218 CEA αCEA-H1 scFv CEA-656E11 279-282 HER2 Tras scFv Trastuzumab 284-285 Human IgG1 313 heavy chain Human IgG4 314 light chain

SEQUENCE LISTING

Sample SEQ ID NO. Fc ProA KO VH3 ProA KO ID Chain Protein DNA (H435R/Y436F) (R19S) SI-75X5 A 1 2 + + B 3 4 SI-75X6 A 5 6 + − B 7 8 SI-75X7 A 9 10 − + B 11 12 SI-75X8 A 13 14 − − B 15 16 SI-75P6 A 17 18 + + B 19 20 SI-75P4 A 21 22 + + B 23 24 SI-75P3 A 25 26 + + B 27 28 SI-75P9 A 29 30 + + B 31 32 SI-75E1 A 33 34 + + B 35 36 SI-75E2 A 37 38 + + B 39 40 SI-75X3 A 41 42 + + B 43 44 SI-75X16 A 45 46 + + B 47 48 SI-75X18 A 49 50 + + B 51 52 SI-75X1 A 53 54 + NA B 55 56 SI-75X2 A 57 58 + + B 59 60 SI-75O2 A 61 62 + NA B 63 64 SI-75O7 A 65 66 + NA B 67 68 SI-68P13 A 69 70 + + B 71 72 SI-68P17 A 73 74 + + B 75 76 SI-68P15 A 77 78 + + B 79 80 SI-68P18 A 81 82 + + B 83 84 SI-68P19 A 85 86 + + B 87 88 SI-68P16 A 89 90 + + B 91 92 SI-75P5 A 93 94 + + B 95 96 SI-75P8 A 97 98 + + B 99 100 SI-75X4 A 101 102 + NA B 103 104 SI-75X17 A 105 106 + NA B 107 108 SI-75X19 A 109 110 + NA B 111 112 SI-75X9 A 113 114 + NA B 115 116 SI-75X11 A 117 118 + NA B 119 120 SI-75X15 A 121 122 + NA B 123 124 SI-75X13 A 125 126 + NA B 127 128 SI-38P11 A 129 130 + + B 131 132 SI-76PM1 A 133 134 + + B 135 136 SI-68X1 A 195 196 − − B 197 198 SI-68X3 A 199 200 − − B 201 202 SI-68X2 A 137 138 − − B 139 140 SI-68E1 A 141 142 − − B 143 144 SI-68E2 A 145 146 − − B 147 148 SI-68P1 A 149 150 − − B 151 152 SI-49R26 A 153 154 + NA B 155 156 SI-49R27 A 157 158 + NA B 159 160 SI-49R25 A 161 162 − − B 163 164 SI-49P_X A 165 166 − − B 167 168 SI-49P8 A 169 170 − − B 171 172 SI-49PM1 A 173 174 + + B 175 176 SI-49P9 A 177 178 − − B 179 180 SI-75XM9 A 297 298 + + B 299 300

SEQ ID NO. Protein ID Format Protein Protein SI-1C3 HC αEGFR mAb 181 182 SI-1C3 LC αEGFR mAb 183 184 SI-1C7 αHER3 Fc-scFv 185 186 SI-9C21 HC αCD3 mAb 187 188 SI-9C21 LC αCD3 mAb 189 190 SI-35FS11 α4-1BB Fc-scFv 191 192 SI-3FS11 αPD-L1 Fc-SCFv 193 194 SI-20C14 HC αCEA mAb 656E11 287 288 SI-20C14 LC αCEA mAb 656E11 289 290

Variable SEQ ID Domains Chains Protein DNA αEGFR VH 203 204 VL 205 206 αEGFR * VH 207 208 VL 209 210 αEGFR * Stapled VH 211 212 VL 213 214 αCD19 VH 215 216 VL 217 218 αCD3 VH 219 220 VL 221 222 αCD3 Stapled VH 223 224 VL 225 226 αCD3 * VH 227 228 VL 229 230 αCD3 ** VH 231 232 VL 233 234 αCD3 *** VH 235 236 VL 237 238 αCD3 **** VH 239 240 VL 241 242 αPDL1 VH 243 244 VL 245 246 α41BB VH 247 248 VL 249 250 41BBL NA 251 252 NKG2D dimer NA 253 254 αHER3 VH 255 256 VL 257 258 αCD20 VH 259 260 VL 261 262 EGFR VHH VHH 263 264 HER3 VHH VHH 265 266 αPDL1 Stapled VH 267 268 VL 269 270 α41BB stapled VH 271 272 VL 273 274 αHER3 stapled VH 275 276 VL 277 278 αCEA VH 279 280 VL 281 282 αHER2 stapled VH 283 284 VL 285 286 αCD3 ***** VH 291 292 VL 293 294 NKG2D monomer NA 295 296

Antibody Kabat CDR AA SEQ ID αCEA 656E11 CDR-H1 301 CDR-H2 302 CDR-H3 303 CDR-L1 304 CDR-L2 305 CDR-L3 306 αCD3 283E3 CDR-H1 307 (BSM/FRS) CDR-H2 308 CDR-H3 309 CDR-L1 310 CDR-L2 311 CDR-L3 312

>Sequence ID 1: SI-75X5 Chain A Amino Acid Sequence QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVY LKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAA GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQD WLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 2: SI-75X5 Chain A Nucleotide Sequence CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGG CATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCT TCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTAT TTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTG GGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCA AGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGG AACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTC TGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCA AGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCT GGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTG TGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATG CCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGAC TGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAA GGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGT CCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAAC AACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAG CCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCC TGAGCCTGAGCCCTGGA >Sequence ID 3: SI-75X5 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCA ASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLL IYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDE QLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDG VEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDEL TKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNR FTQKSLSLSPG >Sequence ID 4: SI-75X5 Chain B Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCC AGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTT ATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACT TACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCT TTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAG CAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAA GGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCC TGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGC CTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCCCTGCCC AGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGA CCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGA GTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGAC TGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTG AGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTG ACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAA TGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGC TGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGC TTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGA >Sequence ID 5: SI-75X6 Chain A Amino Acid Sequence QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVY LKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAA GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQD WLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 6: SI-75X6 Chain A Nucleotide Sequence CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGG CATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCT TCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTAT TTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTG GGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCA AGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGG AACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTC TGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCA AGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCT GGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTG TGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATG CCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGAC TGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAA GGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGT CCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAAC AACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAG CCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCC TGAGCCTGAGCCCTGGA >Sequence ID 7: SI-75X6 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCA ASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLL IYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDE QLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDG VEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDEL TKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNR FTQKSLSLSPG >Sequence ID 8: SI-75X6 Chain B Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCC AGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTT ATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACT TACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCT TTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAG CAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAA GGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCC TGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGC CTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCCCTGCCC AGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGA CCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGA GTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGAC TGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTG AGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTG ACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAA TGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGC TGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGC TTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGA >Sequence ID 9: SI-75X7 Chain A Amino Acid Sequence QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVY LKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAA GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQD WLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 10: SI-75X7 Chain A Nucleotide Sequence CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGG CATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCT TCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTAT TTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTG GGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCA AGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGG AACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTC TGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCA AGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCT GGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTG TGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATG CCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGAC TGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAA GGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGT CCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAAC AACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAG CCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCC TGAGCCTGAGCCCTGGA >Sequence ID 11: SI-75X7 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCA ASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLL IYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDE QLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDG VEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDEL TKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNH YTQKSLSLSPG >Sequence ID 12: SI-75X7 Chain B Amino Acid Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCC AGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTT ATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACT TACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCT TTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAG CAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAA GGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCC TGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGC CTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCCCTGCCC AGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGA CCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGA GTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGAC TGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTG AGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTG ACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAA TGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGC TGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCAC TACACCCAGAAGAGCCTGAGCCTGAGCCCTGGA >Sequence ID 13: SI-75X8 Chain A Amino Acid Sequence QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRETISRSTSTVY LKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAA GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQD WLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 14: SI-75X8 Chain A Nucleotide Acid Sequence CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGG CATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCT TCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTAT TTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTG GGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCA AGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGG AACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTC TGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCA AGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCT GGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTG TGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATG CCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGAC TGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAA GGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGT CCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAAC AACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAG CCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCC TGAGCCTGAGCCCTGGA >Sequence ID 15: SI-75X8 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCA ASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLL IYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDE QLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDG VEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDEL TKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNH YTQKSLSLSPG >Sequence ID 16: SI-75X8 Chain B Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCC AGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTT ATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACT TACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCT TTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAG CAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAA GGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCC TGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGC CTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCCCTGCCC AGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGA CCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGA GTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGAC TGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTG AGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTG ACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAA TGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGC TGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCAC TACACCCAGAAGAGCCTGAGCCTGAGCCCTGGA >Sequence ID 17: SI-75P6 Chain A Amino Acid Sequence DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKGGGGSGGGGSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSC AASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG GSSAITSNNIWGQGTLVTVSSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLE WLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGTLVTVSSASTK GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTY ICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKF NWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLP PSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMH EALHNHYTQKSLSLSPGGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYA AANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGSG GGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPS SKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS >Sequence ID 18: SI-75P6 Chain A Nucleotide Sequence GACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAG TGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCAT CCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGC CTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTT CGGCGGAGGGACCAAGGTGGAGATCAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCG GTGGAGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGT GCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGAT CGGAGTCATTACTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATT CCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGT GGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTC CGGCGGTGGTGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAA CGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAA TGGCTGGGTGTTATTTGGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGA TAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGG CACTGACCTACTACGATTACGAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCCAGTGCTAGCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAA GGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTG TCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC ATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCA CACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTC AACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCG TGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAG CCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCC CCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGC CGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCT TCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGG ATCCGACGTTGTGATGACGCAGTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGG CGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCC GCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGATCTC CGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGT TTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGG GGTGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTG TACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACA TAGGAACAATAAGCTCTGGTGGTAACGTCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCT AGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTC AGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCT >Sequence ID 19: SI-75P6 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCA ASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSSGGGGSGGGGSEIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIK YASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVLRTVAAPSVFIFPPSDEQLK SGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS PVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV HNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKN QVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQ KSLSLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVP SRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEVQLLE SGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 20: SI-75P6 Chain B Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCA GGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAG TATGCAAGTGAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCAT ATCTAGTGTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCG GTACAAAGCTGACCGTTTTACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAA TCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAA CGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCA CCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCG CCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGA AGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGG TCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTG CATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCA CCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCA TCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAAC CAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCC GGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGG ACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAG AAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACC GTCTACGCTCTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCA ACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCT AGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCAC ATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGG GAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCAATTGCTCGAA AGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGG CTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTG GTATAACATACGATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTC CAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAAT GGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA >Sequence ID 21: SI-75P4 Chain A Amino Acid Sequence EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISS VQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGF SLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDY EFAYWGQGTLVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVIT GRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVF PLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE LTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPGGGGGSGGGGSREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLS YKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGR LLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLGSTGSGSKPGSGEGSTKGREGPELSPDDPAG LLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGS VSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGL FRVTPEIPAGLGGGGSGGGGSREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSY KEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRL LHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGL >Sequence ID 22: SI-75P4 Chain A Nucleotide Sequence GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAG TCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAA GTGAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGT GTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAA GCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAAG TACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTT AGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTC AGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTT ATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTAC GAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA GGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGAT TCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACT GGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCT GTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTA TTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTC CCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGA ACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAG GACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAAT CACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTG CCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCC GGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGAC GGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCT CACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCA TCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAG CTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAG CAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCA AGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAAC CACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCCGAGAGGGCCC CGAGCTGTCTCCTGATGACCCAGCAGGCCTCTTGGACTTGCGGCAGGGTATGTTCGCTCAACTTGTGGCTCAGAATG TTCTGCTCATTGATGGACCACTCTCTTGGTATAGTGACCCCGGTCTGGCCGGGGTGAGTCTGACCGGCGGGCTCTCT TATAAAGAGGATACTAAGGAACTGGTCGTAGCAAAAGCGGGCGTTTATTACGTTTTTTTTCAGCTGGAGCTCAGGCG CGTGGTGGCCGGCGAGGGCAGTGGCTCTGTGTCCCTGGCCCTGCACTTACAGCCCTTGAGAAGCGCTGCAGGTGCTG CCGCACTGGCTTTAACTGTTGACCTCCCTCCGGCCTCTTCTGAAGCTAGAAACAGCGCTTTCGGCTTCCAAGGGCGC CTGCTGCACCTGAGCGCAGGCCAGCGCTTAGGTGTGCACCTTCATACAGAGGCCAGGGCCCGACACGCTTGGCAGCT CACACAGGGTGCCACGGTTCTCGGACTTTTCCGCGTTACTCCCGAGATCCCCGCTGGCCTCGGAAGTACTGGTTCTG GGTCTAAACCCGGTTCCGGCGAAGGTAGTACTAAAGGACGAGAAGGGCCAGAGTTAAGTCCAGATGACCCTGCTGGG CTTTTGGACCTGCGGCAGGGCATGTTCGCTCAACTGGTGGCTCAGAACGTGCTGCTGATCGATGGCCCCCTGAGTTG GTACAGCGATCCCGGGCTGGCAGGCGTGTCACTTACAGGGGGCCTCTCTTACAAGGAAGACACCAAGGAGTTAGTGG TCGCTAAGGCTGGCGTGTATTACGTGTTCTTCCAACTGGAGCTGAGAAGGGTTGTGGCAGGAGAGGGTAGCGGCAGC GTGTCTTTAGCCCTTCACTTGCAGCCCCTGAGGTCTGCTGCAGGTGCAGCCGCTCTCGCGCTCACCGTGGATCTCCC CCCAGCCTCATCTGAAGCTAGGAACAGTGCATTTGGCTTTCAGGGACGCTTGCTGCACCTCTCCGCTGGACAGAGGC TGGGCGTGCACCTTCACACAGAGGCCCGTGCCAGGCATGCATGGCAGCTCACTCAGGGGGCAACAGTGCTGGGTCTC TTCCGCGTGACTCCTGAAATACCAGCTGGACTTGGCGGTGGAGGCAGCGGCGGAGGAGGATCTCGTGAGGGGCCAGA ACTGTCCCCCGATGACCCAGCCGGACTGCTCGATCTCAGACAGGGCATGTTCGCTCAGCTTGTAGCCCAAAATGTCC TCCTGATTGACGGCCCTTTGAGCTGGTATAGTGATCCCGGCTTGGCCGGGGTATCTCTGACCGGAGGCCTCTCCTAC AAGGAAGACACCAAAGAGCTGGTGGTGGCAAAAGCGGGGGTGTATTATGTGTTCTTTCAGCTCGAGCTGCGGAGAGT TGTGGCCGGGGAAGGGTCTGGGAGCGTATCTCTTGCACTTCACCTGCAGCCCCTGCGCAGCGCCGCTGGAGCCGCCG CCCTTGCTCTTACTGTGGATCTGCCTCCTGCTTCCTCAGAAGCACGCAACAGCGCCTTCGGCTTTCAAGGACGTCTC CTGCACTTGTCCGCAGGACAGAGGTTGGGCGTCCATTTACACACTGAGGCACGGGCACGGCACGCTTGGCAGCTTAC CCAGGGAGCCACCGTGCTGGGACTCTTTAGAGTGACACCCGAGATCCCCGCTGGCTTGTGA >Sequence ID 23: SI-75P4 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCA ASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIY EASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPS DEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRD ELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALH NRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTL ASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSE VQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSK NTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 24: SI-75P4 Chain B Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCC AAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTAT GAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCAT CAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAA ATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCT GATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACA GTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCT ACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTG GACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCAAGCCGGGAT GAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGA GAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCAC AACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCA GATGACACAGTCACCGTCTACGCTCTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTA TAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTT GCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCAACC CGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGA AAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAA GTGCAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTT TAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCG CCGCCGGGTCTGCTGGTATAACATACGATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAA AATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAG CTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA >Sequence ID 25: SI-75P3 Chain A Amino Acid Sequence EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISS VQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGF SLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDY EFAYWGQGTLVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVIT GRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVF PLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE LTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPGGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLA SGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGSGGGGSE VQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTV DLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS >Sequence ID 26: SI-75P3 Chain A Nucleotide Sequence GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAG TCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAA GTGAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGT GTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAA GCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAAG TACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTT AGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTC AGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTT ATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTAC GAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA GGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGAT TCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACT GGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCT GTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTA TTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTC CCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGA ACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAG GACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAAT CACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTG CCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCC GGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGAC GGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCT CACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCA TCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAG CTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAG CAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCA AGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAAC CACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGAT GACGCAGTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTA GGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCT AGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGG GGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAA AACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGGGGTGGAGGTTCCGAG GTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTT CACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCT CTGGTGGTAACGTCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTA GATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCC CATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCT >Sequence ID 27: SI-75P3 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCA ASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIY EASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPS DEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRD ELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALH NRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTL ASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSE VQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSK NTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 28: SI-75P3 Chain B Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCC AAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTAT GAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCAT CAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAA ATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCT GATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACA GTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCT ACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTG GACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCAAGCCGGGAT GAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGA GAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCAC AACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCA GATGACACAGTCACCGTCTACGCTCTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTA TAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTT GCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCAACC CGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGA AAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAA GTGCAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTT TAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCG CCGCCGGGTCTGCTGGTATAACATACGATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAA AATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAG CTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA >Sequence ID 29: SI-75P9 Chain A Amino Acid Sequence EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISS VQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGF SLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDY EFAYWGQGTLVTVSSGGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGLEWVANIN RDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSASTKGPSVFPL APSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHK PSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGV EVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELT KNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHY TQKSLSLSPGGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASG VPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGSGGGGSEVQ LVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDL QMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS >Sequence ID 30: SI-75P9 Chain A Nucleotide GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAG TCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAA GTGAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGT GTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAA GCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAAG TACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTT AGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTC AGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTT ATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTAC GAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCACA GGTGCAGCTGCAGGAGAGTGGAGGAGGCCTGGTGAAGCCTGGAGGCAGCCTGCGGCTGTCCTGTGCTGCCTCTGGCT TCACCTTCTCCTCCTACTGGATGAGCTGGGTGCGCCAGGCCCCAGGCAAGGGCCTGGAGTGGGTGGCCAACATCAAC AGAGATGGCTCTGCCTCCTACTATGTGGACTCTGTGAAAGGCCGCTTCACCATCTCCAGAGATGATGCCAAGAACAG CCTGTACCTGCAGATGAACAGCCTGAGAGCTGAGGACACAGCTGTGTACTACTGTGCCAGAGACCGAGGTGTGGGCT ACTTTGACCTGTGGGGCAGAGGCACCCTGGTGACTGTGTCCTCTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTG GCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGT GACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCT ACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAG CCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGC ACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCC CTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTG GAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGT CCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGA AAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACC AAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCAAGCTCA CCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGATGACGCA GTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGT ATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTAGTGGA GTACCTTCACGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGGACGC TGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCA CTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGGGGTGGAGGTTCCGAGGTTCAG TTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTAT AAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTG GTAACGTCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTG CAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTG GGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA >Sequence ID 31: SI-75P9 Chain B Amino Acid Sequence DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKGGGGSGGGGSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSC AASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG GSSAITSNNIWGQGTLVTVSSGGGGSGGGGSQSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAP KLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLRTPKANPTVTLF PPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQV THEGSTVEKTVAPTECSGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWY VDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSR DELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEAL HNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKAST LASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGS EVQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNS KNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 32: SI-75P9 Chain B Nucleotide Sequence GACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAG TGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCAT CCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGC CTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTT CGGCGGAGGGACCAAGGTGGAGATCAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCG GTGGAGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGT GCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGAT CGGAGTCATTACTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATT CCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGT GGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGGCGGTGGAGGGTC CGGCGGTGGTGGATCACAGAGTGCCCTGACCCAGCCAGCCTCTGTCTCTGGCAGCCCAGGCCAGTCCATCACCATCT CCTGCACAGGCACCTCCAGTGATGTGGGAGGCTACAACTTTGTGTCCTGGTACCAGCAGCACCCAGGCAAGGCCCCC AAGCTCATGATCTATGATGTGTCTGACAGACCCTCTGGAGTCTCTGACAGATTCTCTGGCTCCAAGAGTGGCAACAC AGCCTCCCTCATCATCTCTGGCCTGCAGGCTGATGATGAAGCTGACTACTACTGCTCCTCCTATGGCTCCTCCTCCA CCCATGTCATCTTTGGAGGAGGCACCAAGGTCACTGTGCTGCGTACGCCCAAGGCCAACCCCACCGTGACCCTGTTC CCCCCAAGCAGCGAGGAACTGCAGGCCAACAAGGCCACCCTCGTGTGCCTGATCAGCGACTTCTACCCTGGCGCCGT GACCGTGGCCTGGAAGGCCGATGGATCTCCCGTGAAGGCCGGCGTGGAAACCACCAAGCCCAGCAAGCAGAGCAACA ACAAATACGCCGCCAGCTCCTACCTGAGCCTGACCCCCGAGCAGTGGAAGTCCCACCGGTCCTACAGCTGCCAGGTC ACACACGAAGGCAGCACCGTGGAAAAGACAGTGGCCCCCACCGAGTGCAGCGGAGGCGACAAAACTCACACATGCCC ACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGA TCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTAC GTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAG CGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAG CCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCAAGCCGG GATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTG GGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCT ATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTG CACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACAT TCAGATGACACAGTCACCGTCTACGCTCTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAAT CTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACT CTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCA ACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAA CGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGC GAAGTGCAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGG TTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTA TCGCCGCCGGGTCTGCTGGTATAACATACGATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCA AAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATT TAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCT >Sequence ID 33: SI-75E1 Chain A Amino Acid Sequence EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISS VQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGF SLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDY EFAYWGQGTLVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVIT GRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVF PLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE LTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPGGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLA SGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGSGGGGSE VQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTV DLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS >Sequence ID 34: SI-75E1 Chain A Nucleotide Sequence GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAG TCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAA GTGAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGT GTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAA GCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAAG TACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTT AGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTC AGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTT ATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTAC GAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA GGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGAT TCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACT GGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCT GTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTA TTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTC CCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGA ACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAG GACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAAT CACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTG CCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCC GGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGAC GGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCT CACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCA TCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAG CTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAG CAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCA AGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAAC CACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGAT GACGCAGTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTA GGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCT AGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGG GGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAA AACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGGGGTGGAGGTTCCGAG GTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTT CACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCT CTGGTGGTAACGTCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTA GATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCC CATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA >Sequence ID 35: SI-75E1 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCA ASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIY EASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPS DEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRD ELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALH NRFTQKSLSLSPG >Sequence ID 36: SI-75E1 Chain B Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCC AAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTAT GAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCAT CAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAA ATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGT GATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCA GTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCT ACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCAC CAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCC CTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCT CCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTG GATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGT GCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCC CCATTGAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGAT GAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGA GAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACA GCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCAC AACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 37: SI-75E2 Chain A Amino Acid Sequence EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISS VQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGF SLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDY EFAYWGQGTLVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVIT GRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVF PLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE LTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPG >Sequence ID 38: SI-75E2 Chain A Nucleotide Sequence GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAG TCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAA GTGAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGT GTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAA GCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAAG TACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTT AGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTC AGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTT ATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTAC GAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA GGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGAT TCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACT GGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCT GTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTA TTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAAGGCCCCTCTGTGTTC CCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGA GCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTG GCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAAC CACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTG CCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCA GGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGAT GGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCT GACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCA TTGAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAG CTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAG CAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCA AGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAAC CACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 39: SI-75E2 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCA ASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIY EASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPS DEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRD ELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALH NRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTL ASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSE VQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSK NTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 40: SI-75E2 Chain B Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCC AAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTAT GAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCAT CAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAA ATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCT GATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACA GTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCT ACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTG GACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCAAGCCGGGAT GAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGA GAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCAC AACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCA GATGACACAGTCACCGTCTACGCTCTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTA TAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTT GCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCAACC CGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGA AAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAA GTGCAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTT TAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCG CCGCCGGGTCTGCTGGTATAACATACGATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAA AATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAG CTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA >Sequence ID 41: SI-75x3 Chain A Amino Acid Sequence EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISS VQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGF SLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDY EFAYWGQGTLVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVIT GRDITYYASWAKGRETISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVF PLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE LTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPG >Sequence ID 42: SI-75X3 Chain A Nucleotide Sequence GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAG TCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAA GTGAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGT GTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAA GCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAAG TACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTT AGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTC AGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTT ATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTAC GAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA GGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGAT TCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACT GGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCT GTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTA TTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAAGGCCCCTCTGTGTTC CCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGA GCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTG GCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAAC CACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTG CCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCA GGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGAT GGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCT GACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCA TTGAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAG CTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAG CAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCA AGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAAC CACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 43: SI-75X3 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCA ASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIY EASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPS DEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRD ELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALH NRFTQKSLSLSPG >Sequence ID 44: SI-75X3 Chain B Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCC AAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTAT GAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCAT CAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAA ATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGT GATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCA GTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCT ACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCAC CAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCC CTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCT CCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTG GATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGT GCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCC CCATTGAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGAT GAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGA GAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACA GCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCAC AACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 45: SI-75X16 Chain A Amino Acid Sequence EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISS VQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGF SLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDY EFAYWGQGTLVTVSSGGGGSGGGGSQVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIF GSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSK STSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTK VDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNA KTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVS LSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSL SLSPG >Sequence ID 46: SI-75X16 Chain A Nucleotide Sequence GAGATCGTGCTGACCCAGTCTCCTTCCACACTGTCTGTGTCTCCCGGCGAGAGAGCCACCTTCAGCTGTAGAGCCTC TCAGTCCATCGGCACCAACATCCACTGGTATCAGCAGAAGCCCGGCAAGCCTCCTCGGCTGCTGATTAAGTACGCCT CCGAGTCCATCAGCGGCATCCCTGACAGATTCTCCGGCTCTGGCTCTGGCACCGAGTTTACCCTGACCATCTCCTCC GTGCAGTCCGAGGATTTCGCCGTGTACTACTGCCAGCAGAACAACAACTGGCCCACCACCTTTGGACCCGGCACCAA GCTGACAGTTCTTGGCGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGAGGAAGCGGTGGCGGCGGATCTCAAG TTCAGTTGCAGCAGTCTGGCCCTGGCCTGGTCAAGCCTTCTGAGACACTGTCCATCACCTGTACCGTGTCCGGCTTC TCCCTGACCAATTACGGCGTGCACTGGATCAGACAGGCCCCTGGCAAAGGACTGGAATGGCTGGGAGTGATTTGGAG CGGCGGCAACACCGACTACAACACCCCTTTCACCAGCCGGTTCACCATCACCAAGGACAACTCCAAGAACCAGGTGT ACTTCAAGCTGCGGAGCGTGCGGGCTGATGACACCGCCATCTACTACTGTGCTCGGGCCCTGACCTACTACGACTAC GAGTTTGCTTACTGGGGCCAGGGCACCCTGGTCACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCACA AGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCA TTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCTTC GGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTATTT GAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTGGG GGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAG AGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAA CTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTG TGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAG GTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCTGG AGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTG TGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATGCC AAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTG GCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAGG CCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCC CTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAA CTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCC GCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTG AGCCTGAGCCCTGGATGA >Sequence ID 47: SI-75X16 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCA ASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLL IYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDE QLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDG VEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDEL TKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNR FTQKSLSLSPG >Sequence ID 48: SI-75X16 Chain B Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCC AGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTT ATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACT TACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCT TTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAG CAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAA GGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCC TGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGC CTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCCCTGCCC AGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGA CCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGA GTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGAC TGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTG AGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTG ACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAA TGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGC TGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGC TTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGA >Sequence ID 49: SI-75X18 Chain A Amino Acid Sequence QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVY LKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAA GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQD WLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLQQSGPG LVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRA DDTAIYYCARALTYYDYEFAYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSEIVLTQSPSTLSVSPGERATFSCRA SQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGT KLTVL >Sequence ID 50: SI-75X18 Chain A Nucleotide Sequence CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGG CATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCT TCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTAT TTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTG GGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCA AGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGG AACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTC TGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCA AGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCT GGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTG TGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATG CCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGAC TGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAA GGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGT CCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAAC AACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAG CCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCC TGAGCCTGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAGGATCCCAAGTTCAGTTGCAGCAGTCTGGCCCTGGC CTGGTCAAGCCTTCTGAGACACTGTCCATCACCTGTACCGTGTCCGGCTTCTCCCTGACCAATTACGGCGTGCACTG GATCAGACAGGCCCCTGGCAAAGGACTGGAATGGCTGGGAGTGATTTGGAGCGGCGGCAACACCGACTACAACACCC CTTTCACCAGCCGGTTCACCATCACCAAGGACAACTCCAAGAACCAGGTGTACTTCAAGCTGCGGAGCGTGCGGGCT GATGACACCGCCATCTACTACTGTGCTCGGGCCCTGACCTACTACGACTACGAGTTTGCTTACTGGGGCCAGGGCAC CCTGGTCACAGTTTCTTCTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGGGGTGGAGGTT CCGAGATCGTGCTGACCCAGTCTCCTTCCACACTGTCTGTGTCTCCCGGCGAGAGAGCCACCTTCAGCTGTAGAGCC TCTCAGTCCATCGGCACCAACATCCACTGGTATCAGCAGAAGCCCGGCAAGCCTCCTCGGCTGCTGATTAAGTACGC CTCCGAGTCCATCAGCGGCATCCCTGACAGATTCTCCGGCTCTGGCTCTGGCACCGAGTTTACCCTGACCATCTCCT CCGTGCAGTCCGAGGATTTCGCCGTGTACTACTGCCAGCAGAACAACAACTGGCCCACCACCTTTGGACCCGGCACC AAGCTGACCGTGCTGTGA >Sequence ID 51: SI-75X18 Chain B Amino Acid Sequence DPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTI TRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVD NALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAP EAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVL HQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQ PENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSQVQLQES GGGLVKPGGSLSLSCAASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMN SLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSQSALTQPASVSGSPGQSITISCTGTSSD VGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGG TKVTVL >Sequence ID 52: SI-75X18 Chain B Nucleotide Sequence GATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAG CCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACT CAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATC ACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGG TGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGA AGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGAC AATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTC CACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCA GCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCA GAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGA AGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAG TGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTG CACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGAC CATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGA ACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAG CCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGT GGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCC AGAAGAGCCTGAGCCTGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAGGATCCCAGGTGCAGCTGCAGGAGTCG GGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTG GATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTT ACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAAC AGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCG TGGCACCCTGGTCACCGTGTCTAGCGGTGGAGGCGGTTCAGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCCAGTCTG CCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAGCAGTGAC GTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATGATGTCAG TGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCC TCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGG ACCAAGGTGACCGTCCTATAA >Sequence ID 53: SI-75X1 Chain A Amino Acid Sequence EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISS VQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGF SLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDY EFAYWGQGTLVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVIT GRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVF PLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE LTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPG >Sequence ID 54: SI-75X1 Chain A Nucleotide Sequence GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAG TCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAA GTGAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGT GTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAA GCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAAG TACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTT AGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTC AGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTT ATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTAC GAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA GGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGAT TCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACT GGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCT GTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTA TTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAAGGCCCCTCTGTGTTC CCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGA GCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTG GCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAAC CACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTG CCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCA GGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGAT GGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCT GACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCA TTGAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAG CTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAG CAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCA AGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAAC CACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 55: SI-75X1 Chain B Amino Acid Sequence DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWK VDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCP APEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLT VLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESN GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG >Sequence ID 56: SI-75X1 Chain B Nucleotide Sequence GACGTGGTCATGACACAGAGCCCTTCCACACTGTCTGCCTCCGTGGGCGATAGAGTGACCATCAACTGTCAGGCCTC CGAGTCCATCTCCTCTTGGCTGGCTTGGTATCAGCAGAAGCCTGGCAAGGCCCCTAAGCTGCTGATCTACGAGGCTT CCAAGCTGGCCTCTGGCGTGCCCTCTAGATTTTCCGGCTCTGGCTCTGGCACCGAGTTTACCCTGACAATCTCCAGC CTGCAGCCTGACGACTTCGCCACCTACTACTGCCAAGGCTACTTCTACTTCATCTCCCGGACCTACGTGAACTCCTT CGGCGGAGGCACCAAGGTGGAGATCAAGCGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGC AGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAG GTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCT GTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCC TGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCCCTGCCCA GCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGAC CCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAG TGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACT GTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGA GAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGA CCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAAT GGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCT GACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCT TCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 57: SI-75X2 Chain A Amino Acid Sequence EVQLVESGGGLVQPGGSLRLSCAASGETISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNT LYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFP EPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPP CPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSV LTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWE SNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 58: SI-75X2 Chain A Nucleotide Sequence GAGGTGCAGCTGGTTGAATCTGGCGGAGGATTGGTTCAGCCTGGCGGCTCTCTGAGACTGTCTTGTGCCGCTTCTGG CTTCACCATCTCCACCAACGCCATGTCCTGGGTCCGACAGGCTCCTGGCAAAGGCCTGGAATGGATCGGCGTGATCA CCGGCAGAGATATTACCTACTACGCCTCCTGGGCCAAGGGCAGATTCACCATCAGCCGGGACAACTCCAAGAACACC CTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACTACTGTGCTAGAGATGGCGGCAGCAGCGC CATCACCTCCAACAATATTTGGGGCCAGGGCACCCTGGTCACTGTGTCCTCTGCTAGCACCAAAGGCCCCTCTGTGT TCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCA GAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTC TGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGA ACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCC TGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTC CAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGG ATGGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTG CTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCC CATTGAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATG AGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAG AGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTC CAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACA ACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 59: SI-75X2 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCA ASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIY EASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPS DEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRD ELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALH NRFTQKSLSLSPG >Sequence ID 60: SI-75X2 Chain B Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCC AAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTAT GAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCAT CAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAA ATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGT GATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCA GTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCT ACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCAC CAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCC CTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCT CCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTG GATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGT GCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCC CCATTGAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGAT GAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGA GAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACA GCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCAC AACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 61: SI-75O2 Chain A Amino Acid Sequence EVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNT LYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFP EPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPP CPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSV LTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWE SNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 62: SI-75O2 Chain A Nucleotide Sequence GAGGTGCAGCTGGTTGAATCTGGCGGAGGATTGGTTCAGCCTGGCGGCTCTCTGAGACTGTCTTGTGCCGCTTCTGG CTTCACCATCTCCACCAACGCCATGTCCTGGGTCCGACAGGCTCCTGGCAAAGGCCTGGAATGGATCGGCGTGATCA CCGGCAGAGATATTACCTACTACGCCTCCTGGGCCAAGGGCAGATTCACCATCAGCCGGGACAACTCCAAGAACACC CTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACTACTGTGCTAGAGATGGCGGCAGCAGCGC CATCACCTCCAACAATATTTGGGGCCAGGGCACCCTGGTCACTGTGTCCTCTGCTAGCACCAAAGGCCCCTCTGTGT TCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCA GAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTC TGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGA ACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCC TGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTC CAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGG ATGGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTG CTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCC CATTGAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATG AGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAG AGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTC CAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACA ACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 63: SI-75O2 Chain B Amino Acid Sequence DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWK VDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCP APEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLT VLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESN GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG >Sequence ID 64: SI-75O2 Chain B Nucleotide Sequence GACGTGGTCATGACACAGAGCCCTTCCACACTGTCTGCCTCCGTGGGCGATAGAGTGACCATCAACTGTCAGGCCTC CGAGTCCATCTCCTCTTGGCTGGCTTGGTATCAGCAGAAGCCTGGCAAGGCCCCTAAGCTGCTGATCTACGAGGCTT CCAAGCTGGCCTCTGGCGTGCCCTCTAGATTTTCCGGCTCTGGCTCTGGCACCGAGTTTACCCTGACAATCTCCAGC CTGCAGCCTGACGACTTCGCCACCTACTACTGCCAAGGCTACTTCTACTTCATCTCCCGGACCTACGTGAACTCCTT CGGCGGAGGCACCAAGGTGGAGATCAAGCGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGC AGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAG GTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCT GTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCC TGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCCCTGCCCA GCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGAC CCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAG TGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACT GTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGA GAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGA CCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAAT GGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCT GACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCT TCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 65: SI-7507 Chain A Amino Acid Sequence QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVY LKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAA GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQD WLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 66: SI-7507 Chain A Nucleotide Sequence CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGG CATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCT TCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTAT TTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTG GGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCA AGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGG AACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTC TGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCA AGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCT GGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTG TGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATG CCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGAC TGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAA GGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGT CCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAAC AACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAG CCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCC TGAGCCTGAGCCCTGGA >Sequence ID 67: SI-7507 Chain B Amino Acid Sequence DPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTI TRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVD NALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAP EAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVL HQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQ PENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG >Sequence ID 68: SI-7507 Chain B Nucleotide Sequence GATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAG CCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACT CAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATC ACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGG TGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGA AGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGAC AATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTC CACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCA GCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCA GAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGA AGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAG TGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTG CACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGAC CATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGA ACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAG CCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGT GGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCC AGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 69: SI-68P13 Chain A Amino Acid Sequence EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISS VQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGF SLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDY EFAYWGQGTLVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVIT GRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVF PLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE LTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPGGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLA SGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGSGGGGSE VQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTV DLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS >Sequence ID 70: SI-68P13 Chain A Nucleotide Sequence GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAG TCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAA GTGAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGT GTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAA GCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAAG TACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTT AGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTC AGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTT ATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTAC GAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA GGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGAT TCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACT GGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCT GTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTA TTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTC CCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGA ACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAG GACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAAT CACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTG CCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCC GGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGAC GGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCT CACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCA TCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAG CTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAG CAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCA AGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAAC CACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGAT GACGCAGTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTA GGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCT AGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGG GGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAA AACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGGGGTGGAGGTTCCGAG GTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTT CACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCT CTGGTGGTAACGTCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTA GATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCC CATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA >Sequence ID 71: SI-68P13 Chain B Amino Acid Sequence ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSM EPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGGSGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFS LSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSY YFDYWGQGTLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEAS KLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQ LKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGL SSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGV EVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELT KNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRF TQKSLSLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASG VPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEVQL LESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 72: SI-68P13 Chain B Nucleotide Sequence GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATC AAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCA AGCTGGCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATG GAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGT GACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTCA CATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCT CTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTG GTGGGACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAG TGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTAC TACTTTGATTATTGGGGGCAGGGGACTCTCGTCACGGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA CGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTG AGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCATCC AAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCT GCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCG GCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAG TTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGT GGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCA GCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTG AGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGC ACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCC CTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTG GAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGT CCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGA AAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACC AAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCA CCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACA GTCACCGTCTACGCTCTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCAC ACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGT GTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCAACCCGACGACTT CGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTG TGTTGGGAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCAATTG CTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAG TAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGT CTGCTGGTATAACATACGATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTG TACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTA TGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA >Sequence ID 73: SI-68P17 Chain A Amino Acid Sequence DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKGGGGSGGGGSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSC AASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDG GSSAITSNNIWGQGTLVTVSSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLE WLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGTLVTVSSASTK GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTY ICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKF NWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLP PSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMH EALHNHYTQKSLSLSPGGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYA AANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGSG GGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPS SKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS >Sequence ID 74: SI-68P17 Chain A Nucleotide Sequence GACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAG TGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCAT CCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGC CTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTT CGGCGGAGGGACCAAGGTGGAGATCAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCG GTGGAGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGT GCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGAT CGGAGTCATTACTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATT CCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGT GGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTC CGGCGGTGGTGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAA CGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAA TGGCTGGGTGTTATTTGGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGA TAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGG CACTGACCTACTACGATTACGAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCCAGTGCTAGCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAA GGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTG TCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC ATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCA CACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTC AACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCG TGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAG CCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCC CCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGC CGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCT TCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGG ATCCGACGTTGTGATGACGCAGTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGG CGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCC GCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGATCTC CGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGT TTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGG GGTGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTG TACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACA TAGGAACAATAAGCTCTGGTGGTAACGTCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCT AGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTC AGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA >Sequence ID 75: SI-68P17 Chain B Amino Acid Sequence ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSM EPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGGSGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFS LSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSY YFDYWGQGTLVTVSSGGGGSGGGGSEIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYAS ESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVLRTVAAPSVFIFPPSDEQLKSGT ASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVT KSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNA KTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVS LWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSL SLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRF SGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEVQLLESGG GLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMN SLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 76: SI-68P17 Chain B Nucleotide Sequence GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATC AAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCA AGCTGGCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATG GAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGT GACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTCA CATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCT CTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTG GTGGGACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAG TGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTAC TACTTTGATTATTGGGGGCAGGGGACTCTCGTCACGGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA AATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTC AATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAAGT GAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGT GCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGC TGACCGTTTTACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACT GCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGC TGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACA AAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGG GGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCG TGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTG GCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGC CTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAA CTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCA GGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTC TCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCT CTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATC AACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTC TCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTG TCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAG GAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCAATTGCTCGAAAGTGGTGGC GGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATAT GTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACAT ACGATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAAT AGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTG GGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA >Sequence ID 77: SI-68P15 Chain A Amino Acid Sequence EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGQGTKLTVLGGGGSGGGGSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSC AASGFTISTNAMSWVRQAPGKGLEWVGVITGRDITYYASWAKGRFTISRDTSKNTVYLQMNSLRAEDTAVYYCARDG GSSAITSNNIWGQGTLVTVSSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLE WLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGTLVTVSSASTK GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTY ICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKF NWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLP PSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMH EALHNHYTQKSLSLSPGGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYA AANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGSG GGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPS SKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS >Sequence ID 78: SI-68P15 Chain A Nucleotide Sequence GAAATCGTTATGACGCAGAGTCCCTCCACGCTCTCCGCTAGTGTCGGGGATCGCGTCATTATCACATGCCAGGCCTC CGAGTCAATCAGCAGCTGGCTTGCATGGTATCAACAGAAGCCGGGAAAAGCTCCTAAATTGCTGATCTATGAAGCGT CAAAATTGGCGTCTGGTGTCCCATCTAGGTTCTCCGGCTCTGGGTCTGGTGCGGAATTTACTTTGACAATCTCCAGT CTTCAACCAGACGATTTCGCTACCTACTACTGCCAAGGGTATTTCTATTTTATAAGCCGGACATATGTAAACTCCTT CGGCCAAGGAACAAAGTTGACTGTTCTTGGTGGCGGAGGCAGTGGTGGCGGGGGCAGCGGAGGTGGTGGTTCAGGGG GTGGTGGGAGCGAAGTCCAATTGGTAGAAAGTGGCGGTGGTCTGGTGCAACCTGGTGGATCTCTTCGCCTCTCATGC GCCGCTAGTGGCTTTACTATTTCAACTAATGCGATGAGCTGGGTTCGCCAGGCCCCCGGCAAAGGACTTGAGTGGGT CGGCGTCATCACCGGCAGGGACATTACATACTATGCGAGTTGGGCAAAGGGCAGGTTCACGATTAGCCGCGATACTT CAAAGAATACCGTTTACCTTCAAATGAATAGCTTGAGGGCGGAAGACACAGCTGTGTATTACTGCGCGAGGGATGGA GGTAGTTCCGCCATAACTTCCAACAACATATGGGGACAAGGCACGCTGGTTACTGTCTCGAGTGGCGGTGGAGGGTC CGGCGGTGGTGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAA CGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAA TGGCTGGGTGTTATTTGGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGA TAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGG CACTGACCTACTACGATTACGAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCCAGTGCTAGCACCAAG GGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAA GGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTG TCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTAC ATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCA CACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACA CCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTC AACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCG TGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAG CCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCC CCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGC CGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCT TCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCAT GAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGG ATCCGACGTTGTGATGACGCAGTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGG CGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCC GCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGATCTC CGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGT TTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGG GGTGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTG TACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACA TAGGAACAATAAGCTCTGGTGGTAACGTCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCT AGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTC AGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA >Sequence ID 79: SI-68P15 Chain B Amino Acid Sequence ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSM EPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGGSGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFS LSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSY YFDYWGQGTLVTVSSGGGGSGGGGSEIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYAS ESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVLRTVAAPSVFIFPPSDEQLKSGT ASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVT KSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNA KTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVS LWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSL SLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRF SGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEVQLLESGG GLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMN SLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 80: SI-68P15 Chain B Nucleotide Sequence GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATC AAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCA AGCTGGCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATG GAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGT GACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTCA CATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCT CTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTG GTGGGACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAG TGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTAC TACTTTGATTATTGGGGGCAGGGGACTCTCGTCACGGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA AATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTC AATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAAGT GAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGT GCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGC TGACCGTTTTACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACT GCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGC TGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACA AAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGG GGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCG TGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTG GCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGC CTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAA CTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCA GGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTC TCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCT CTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATC AACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTC TCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTG TCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAG GAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCAATTGCTCGAAAGTGGTGGC GGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATAT GTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACAT ACGATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAAT AGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTG GGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA >Sequence ID 81: SI-68P18 Chain A Amino Acid Sequence DVQMTQSPSTLSATVGQRVTINCQASESISSWLAWYQQKPGQPPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISS LQSDDFATYYCQGYFYFISRTYVNSFGGGTRVEIKGGGGSGGGGSGGGGSGGGGSQQLLESGGRLIKPGATLRLTCK TSGFTISTNAMSWVRQPPGKGLEWIGVITGRDITYYASWAKGRFTISKTSINTVFLQMRSLRAEDTAVYYCARDGGS SAITSNNIWGRGTLVTVSSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWL GVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGTLVTVSSASTKGP SVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNW YVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAA NLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGSGGG GSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSK NTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS >Sequence ID 82: SI-68P18 Chain A Nucleotide Sequence GATGTGCAGATGACCCAGAGCCCGAGCACCCTGAGCGCGACCGTGGGCCAGCGCGTGACCATTAACTGCCAGGCGAG CGAAAGCATTAGCAGCTGGCTGGCGTGGTATCAGCAGAAACCGGGCCAGCCGCCGAAACTGCTGATTTATGAAGCGA GCAAACTGGCGAGCGGCGTGCCGAGCCGCTTTAGCGGCAGCGGCAGCGGCACCGAATTTACCCTGACCATTAGCAGC CTGCAGAGCGATGATTTTGCGACCTATTATTGCCAGGGCTATTTTTATTTTATTAGCCGCACCTATGTGAACAGCTT TGGCGGCGGCACCCGCGTGGAAATTAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCG GTGGAGGATCACAGCAGCTGCTGGAAAGCGGCGGCCGCCTGATTAAACCGGGCGCGACCCTGCGCCTGACCTGCAAA ACCAGCGGCTTTACCATTAGCACCAACGCGATGAGCTGGGTGCGCCAGCCGCCGGGCAAAGGCCTGGAATGGATTGG CGTGATTACCGGCCGCGATATTACCTATTATGCGAGCTGGGCGAAAGGCCGCTTTACCATTAGCAAAACCAGCATTA ACACCGTGTTTCTGCAGATGCGCAGCCTGCGCGCGGAAGATACCGCGGTGTATTATTGCGCGCGCGATGGCGGCAGC AGCGCGATTACCAGCAACAACATTTGGGGCCGCGGCACCCTGGTGACCGTGAGCAGCGGCGGTGGAGGGTCCGGCGG TGGTGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTA CTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTG GGTGTTATTTGGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTC CAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGA CCTACTACGATTACGAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCCAGTGCTAGCACCAAGGGCCCA TCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTAC AGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGC AACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCA TGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGG TACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGT CAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCC CAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCC CGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCC TCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCT CTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGA CGTTGTGATGACGCAGTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCC AAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCC AACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGATCTCCGATTT GGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCG GAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGGGGTGGA GGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGC TTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAA CAATAAGCTCTGGTGGTAACGTCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAA AACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTA TTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA >Sequence ID 83: SI-68P18 Chain B Amino Acid Sequence ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSM EPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGGSGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFS LSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSY YFDYWGQGTLVTVSSGGGGSGGGGSEIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYAS ESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVLRTVAAPSVFIFPPSDEQLKSGT ASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVT KSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNA KTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVS LWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSL SLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRF SGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEVQLLESGG GLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMN SLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 84: SI-68P18 Chain B Nucleotide Sequence GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATC AAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCA AGCTGGCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATG GAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGT GACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTCA CATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCT CTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTG GTGGGACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAG TGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTAC TACTTTGATTATTGGGGGCAGGGGACTCTCGTCACGGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA AATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTC AATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAAGT GAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGT GCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGC TGACCGTTTTACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACT GCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGC TGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACA AAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGG GGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCG TGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTG GCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGC CTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAA CTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCA GGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTC TCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCT CTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATC AACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTC TCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTG TCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAG GAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCAATTGCTCGAAAGTGGTGGC GGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATAT GTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACAT ACGATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAAT AGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTG GGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA >Sequence ID 85: SI-68P19 Chain A Amino Acid Sequence DVVMTQSPSSLSASVGDRVTISCQASESISSWLAWYQQKPGQAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISS LEPEDFATYYCQGYFYFISRTYVNSFGGGTKVEIKGGGGSGGGGSGGGGSGGGGSQQLVESGGGLVKPGGSLRLSCA ASGFTISTNAMSWVRQAPGKGLEWVGVITGRDITYYASWAKGRFTISKTSKNTVYLQMNSLRAEDTAVYYCARDGGS SAITSNNIWGQGTLVTVSSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWL GVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGTLVTVSSASTKGP SVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYIC NVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNW YVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAA NLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGSGGG GSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSK NTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS >Sequence ID 86: SI-68P19 Chain A Nucleotide Sequence GATGTGGTGATGACCCAGAGCCCGAGCAGCCTGAGCGCGAGCGTGGGCGATCGCGTGACCATTAGCTGCCAGGCGAG CGAAAGCATTAGCAGCTGGCTGGCGTGGTATCAGCAGAAACCGGGCCAGGCGCCGAAACTGCTGATTTATGAAGCGA GCAAACTGGCGAGCGGCGTGCCGAGCCGCTTTAGCGGCAGCGGCAGCGGCACCGAATTTACCCTGACCATTAGCAGC CTGGAACCGGAAGATTTTGCGACCTATTATTGCCAGGGCTATTTTTATTTTATTAGCCGCACCTATGTGAACAGCTT TGGCGGCGGCACCAAAGTGGAAATTAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCG GTGGAGGATCACAGCAGCTGGTGGAAAGCGGCGGCGGCCTGGTGAAACCGGGCGGCAGCCTGCGCCTGAGCTGCGCG GCGAGCGGCTTTACCATTAGCACCAACGCGATGAGCTGGGTGCGCCAGGCGCCGGGCAAAGGCCTGGAATGGGTGGG CGTGATTACCGGCCGCGATATTACCTATTATGCGAGCTGGGCGAAAGGCCGCTTTACCATTAGCAAAACCAGCAAAA ACACCGTGTATCTGCAGATGAACAGCCTGCGCGCGGAAGATACCGCGGTGTATTATTGCGCGCGCGATGGCGGCAGC AGCGCGATTACCAGCAACAACATTTGGGGCCAGGGCACCCTGGTGACCGTGAGCAGCGGCGGTGGAGGGTCCGGCGG TGGTGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTA CTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTG GGTGTTATTTGGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTC CAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGA CCTACTACGATTACGAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCCAGTGCTAGCACCAAGGGCCCA TCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTAC AGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGC AACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCA TGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGG TACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGT CAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCC CAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCC CGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGA GTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCC TCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCT CTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGA CGTTGTGATGACGCAGTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCC AAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCC AACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGATCTCCGATTT GGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCG GAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGGGGTGGA GGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGC TTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAA CAATAAGCTCTGGTGGTAACGTCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAA AACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTA TTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA >Sequence ID 87: SI-68P19 Chain B Amino Acid Sequence ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSM EPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGGSGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFS LSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSY YFDYWGQGTLVTVSSGGGGSGGGGSEIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYAS ESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVLRTVAAPSVFIFPPSDEQLKSGT ASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVT KSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNA KTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVS LWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSL SLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRF SGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEVQLLESGG GLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMN SLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 88: SI-68P19 Chain B Nucleotide Sequence GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATC AAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCA AGCTGGCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATG GAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGT GACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTCA CATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCT CTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTG GTGGGACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAG TGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTAC TACTTTGATTATTGGGGGCAGGGGACTCTCGTCACGGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA AATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTC AATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAAGT GAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGT GCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGC TGACCGTTTTACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACT GCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGC TGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACA AAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGG GGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCG TGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTG GCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGC CTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAA CTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCA GGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTC TCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCT CTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATC AACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTC TCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTG TCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAG GAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCAATTGCTCGAAAGTGGTGGC GGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATAT GTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACAT ACGATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAAT AGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTG GGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA >Sequence ID 89: SI-68P16 Chain A Amino Acid Sequence DPVLTQSPSSLSASVGDRVTISCQSSQSVAKNNNLAWFQQKPGQAPKLLIYSASTLAAGVPSRFSGSGSGTDFTLTI SSVQPEDFATYYCSARDSGNIQSFGGGTKVEIKGGGGSGGGGSGGGGSGGGGSQQLVESGGGLVKPGGSLRLSCAAS GIDLSSNAIGWVRQAPGKGLEWVGVIFGSGNTYYASWAKGRFTISRSKNTVYLQMNSLRAEDTAVYYCARGGYSSDI WGQGTLVTVSSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLGVIWSGGN TDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGTLVTVSSASTKGPSVFPLAPS SKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSN TKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVH NAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQ VSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPS RFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGSGGGGSEVQLVE SGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMN SLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS >Sequence ID 90: SI-68P16 Chain A Nucleotide Sequence GATCCAGTTCTGACACAAAGTCCATCCAGCCTGTCTGCCTCAGTCGGCGACAGAGTGACCATCAGTTGCCAGAGCTC ACAGTCTGTGGCTAAGAACAACAACTTGGCGTGGTTCCAACAGAAACCTGGACAGGCTCCGAAATTGCTGATCTATT CTGCTTCCACGCTTGCTGCTGGTGTTCCTTCCCGCTTTTCAGGTAGTGGTAGCGGGACAGACTTCACTTTGACTATA AGCAGCGTGCAGCCTGAAGATTTTGCGACCTACTATTGTTCTGCTAGAGACAGTGGAAATATTCAGTCCTTTGGGGG GGGAACGAAGGTCGAAATAAAGGGCGGCGGAGGGTCTGGTGGGGGTGGCAGTGGTGGTGGAGGAAGTGGTGGCGGTG GTTCCCAACAGTTGGTTGAGTCTGGTGGCGGTCTCGTTAAGCCTGGAGGGTCCCTTCGGCTTAGTTGTGCGGCCTCT GGGATCGACCTGTCTAGCAACGCTATAGGATGGGTACGGCAAGCTCCGGGCAAAGGCCTTGAGTGGGTCGGCGTTAT TTTTGGGAGCGGTAATACGTACTACGCCAGCTGGGCAAAAGGTAGGTTCACTATCAGTCGATCAAAGAACACGGTAT ATCTTCAGATGAACAGTCTCCGGGCGGAGGACACCGCGGTTTATTATTGCGCAAGGGGGGGATACTCCTCAGACATA TGGGGCCAAGGTACTTTGGTGACGGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAAGTACAGTTGCA GCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGA ACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTCAGGTGGAAAT ACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTTATTTCAAGTT GAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTACGAATTTGCGT ATTGGGGGCAAGGGACTCTTGTAACAGTCTCCAGTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCC TCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTC GTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCA GCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAAC ACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGC CGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCA CATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCAT AATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCA GGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCT CCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAG GTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGA GAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACA AGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAG AGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGATGACGCAGTCTCCTAG TTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGTATCTGTCTT GGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTAGTGGAGTACCTTCA CGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGGACGCTGCCACGTA TTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCACTGTACTTG GTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGGGGTGGAGGTTCCGAGGTTCAGTTGGTTGAA AGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTATAAGTTCATA TCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTGGTAACGTCT ATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTGCAAATGAAC TCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTGGGGGCAGGG CACATTGGTTACCGTGTCCTCTTGA >Sequence ID 91: SI-68P16 Chain B Amino Acid Sequence ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSM EPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGGSGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFS LSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSY YFDYWGQGTLVTVSSGGGGSGGGGSEIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYAS ESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVLRTVAAPSVFIFPPSDEQLKSGT ASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVT KSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNA KTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVS LWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSL SLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRF SGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEVQLLESGG GLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMN SLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 92: SI-68P16 Chain B Nucleotide Sequence GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATC AAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCA AGCTGGCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATG GAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGT GACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTCA CATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCT CTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTG GTGGGACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAG TGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTAC TACTTTGATTATTGGGGGCAGGGGACTCTCGTCACGGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA AATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTC AATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAAGT GAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGT GCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGC TGACCGTTTTACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACT GCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCA ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGC TGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACA AAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGG GGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCG TGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTG GCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGC CTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAA CTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCA GGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTC TCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCT CTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATC AACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTC TCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTG TCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAG GAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCAATTGCTCGAAAGTGGTGGC GGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATAT GTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACAT ACGATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAAT AGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTG GGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA >Sequence ID 93: SI-75P5 Chain A Amino Acid Sequence EVQLQESGGGLVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKN TVYLQMNSLKPEDTAVYYCAAALGVLVLAPGNVYSYWGQGTQVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRL SCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAR DGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFP AVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPK DTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSN KALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDG SFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITC QASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGG AFGGGTKLTVLGGGGSGGGGSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLE YI GT1SSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS >Sequence ID 94: SI-75P5 Chain A Nucleotide Sequence GAGGTGCAGCTGCAGGAGTCTGGCGGCGGCCTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGG CCGCTCCTTCAACTCCTACACCATGGGCTGGTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCC TGTGGAGTGGCCCCACCACCTACTATGCTGACTCTGTGAAGGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAAC ACTGTGTACCTGCAGATGAACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCT GGTGCTGGCCCCTGGCAATGTGTACAGCTACTGGGGCCAGGGCACCCAGGTGACTGTCTCGAGCGGCGGTGGAGGGT CCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTC TCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGA GTGGATCGGAGTCATTACTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAG ACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGA GACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCAC CAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGG TCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCG GCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGAC CTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAA CTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAG GACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAA GTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGT ACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAAC AAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTATACCCT GCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACA TCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGC TCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGAT GCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTG GGGGATCCGACGTTGTGATGACGCAGTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGC CAGGCGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTA CGCCGCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGA TCTCCGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGG GCGTTTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTC TGGGGGTGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTT CTTGTACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAA TACATAGGAACAATAAGCTCTGGTGGTAACGTCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCC TTCTAGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGG ATTCAGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA >Sequence ID 95: SI-75P5 Chain B Amino Acid Sequence QVQLVQSGGGLVQAGGSLSLSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKN TLYLQMDSLKPEDTAVYYCAADLQYGSSWPQRSSAEYDYWGQGTTVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGD RVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYF ISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQ DSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKP KDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVS NKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSD GSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTIT CQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDN VFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEVQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGL EWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 96: SI-75P5 Chain B Nucleotide Sequence CAGGTGCAGCTGGTGCAGTCTGGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGG CCGCACCTTCTCCATGTACACCATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACA GAGGCAGAGGCCTGAGCCCAGACATTGCTGACTCTGTGAATGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAAC ACCCTGTACCTGCAGATGGACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGG CAGCAGCTGGCCTCAGAGGAGCTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTCTCGAGCGGCG GTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGAC AGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGC CCCTAAGCTCCTGATCTATGAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGA CAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTT ATTAGTCGTACTTATGTAAATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGT CTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATC CCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAG GACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTA CGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACA AAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCC AAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGT CAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCA CGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCC AACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACAC CCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCG ACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGAC GGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGT GATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCG GTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCTCTCAGCCTCAGTAGGCGATAGGGTGACTATCACC TGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCAT CTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGA CGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAAT GTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTC CGGCGGGGGTGGAAGCGAAGTGCAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCT CTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTT GAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACGATGCAAACTGGGCGAAAGGGCGCTTCACAAT CTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATT GCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA >Sequence ID 97: SI-75P8 Chain A Amino Acid Sequence EVQLQESGGGLVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKN TVYLQMNSLKPEDTAVYYCAAALGVLVLAPGNVYSYWGQGTQVTVSSGGGGSGGGGSQVQLQESGGRLVQPGEPLSL TCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGG YSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSG LYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISR TPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPI EKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLT NYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFA YWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSEIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPR LLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVL >Sequence ID 98: SI-75P8 Chain A Nucleotide Sequence GAGGTGCAGCTGCAGGAGTCTGGCGGCGGCCTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGG CCGCTCCTTCAACTCCTACACCATGGGCTGGTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCC TGTGGAGTGGCCCCACCACCTACTATGCTGACTCTGTGAAGGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAAC ACTGTGTACCTGCAGATGAACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCT GGTGCTGGCCCCTGGCAATGTGTACAGCTACTGGGGCCAGGGCACCCAGGTGACTGTCTCGAGCGGCGGTGGAGGGT CCGGCGGTGGTGGATCACAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTG ACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGA GTGGATCGGAGTTATCTTCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGA GCACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGG TACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCC TCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGC CTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGC CTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCA CAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCC CAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGG ACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGG AGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGA CTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATT GAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCT GACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCA ATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAG CTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCA CTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAGGATCCCAAGTTCAGTTGC AGCAGTCTGGCCCTGGCCTGGTCAAGCCTTCTGAGACACTGTCCATCACCTGTACCGTGTCCGGCTTCTCCCTGACC AATTACGGCGTGCACTGGATCAGACAGGCCCCTGGCAAAGGACTGGAATGGCTGGGAGTGATTTGGAGCGGCGGCAA CACCGACTACAACACCCCTTTCACCAGCCGGTTCACCATCACCAAGGACAACTCCAAGAACCAGGTGTACTTCAAGC TGCGGAGCGTGCGGGCTGATGACACCGCCATCTACTACTGTGCTCGGGCCCTGACCTACTACGACTACGAGTTTGCT TACTGGGGCCAGGGCACCCTGGTCACAGTTTCTTCTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGG TTCTGGGGGTGGAGGTTCCGAGATCGTGCTGACCCAGTCTCCTTCCACACTGTCTGTGTCTCCCGGCGAGAGAGCCA CCTTCAGCTGTAGAGCCTCTCAGTCCATCGGCACCAACATCCACTGGTATCAGCAGAAGCCCGGCAAGCCTCCTCGG CTGCTGATTAAGTACGCCTCCGAGTCCATCAGCGGCATCCCTGACAGATTCTCCGGCTCTGGCTCTGGCACCGAGTT TACCCTGACCATCTCCTCCGTGCAGTCCGAGGATTTCGCCGTGTACTACTGCCAGCAGAACAACAACTGGCCCACCA CCTTTGGACCCGGCACCAAGCTGACCGTGCTGTGA >Sequence ID 99: SI-75P8 Chain B Amino Acid Sequence QVQLVQSGGGLVQAGGSLSLSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKN TLYLQMDSLKPEDTAVYYCAADLQYGSSWPQRSSAEYDYWGQGTTVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQ RVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARD SGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKD TLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGS FFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCAA SGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRG VGYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSQSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKA PKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVL >Sequence ID 100: SI-75P8 Chain B Nucleotide Sequence CAGGTGCAGCTGGTGCAGTCTGGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGG CCGCACCTTCTCCATGTACACCATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACA GAGGCAGAGGCCTGAGCCCAGACATTGCTGACTCTGTGAATGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAAC ACCCTGTACCTGCAGATGGACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGG CAGCAGCTGGCCTCAGAGGAGCTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTCTCGAGTGGCG GTGGAGGGTCCGGCGGTGGTGGATCAGATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAG AGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGG TAAACCTCCTAAACTCCTTATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTT CCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGAT TCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCAT CTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAG AAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGC AAGGACAGCACCTACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTG TGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCC ACACCTGCCCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGAC ACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTT CAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACC GAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAG GCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCC TCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTG CTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCC TTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCA TGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAG GATCCCAGGTGCAGCTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCC TCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAA CATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCA AGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGG GTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTGTCTAGCGGTGGAGGCGGTTCAGGCGGAGGTGG TTCCGGCGGTGGCGGCTCCCAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCA TCTCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCC CCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAA CACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCA GCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTATAA >Sequence ID 101: SI-75X4 Chain A Amino Acid Sequence EVQLQESGGGLVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKN TVYLQMNSLKPEDTAVYYCAAALGVLVLAPGNVYSYWGQGTQVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRL SCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMSSLRSEDTAVYYCAR DGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFP AVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPK DTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSN KALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDG SFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 102: SI-75X4 Chain A Nucleotide Sequence GAGGTGCAGCTGCAGGAGTCTGGCGGCGGCCTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGG CCGCTCCTTCAACTCCTACACCATGGGCTGGTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCC TGTGGAGTGGCCCCACCACCTACTATGCTGACTCTGTGAAGGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAAC ACTGTGTACCTGCAGATGAACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCT GGTGCTGGCCCCTGGCAATGTGTACAGCTACTGGGGCCAGGGCACCCAGGTGACTGTCTCGAGCGGAGGAGGAGGCT CTGGAGGAGGAGGCAGTGAGGTGCAGCTGGTGGAGAGTGGAGGAGGCCTGGTGCAGCCTGGAGGCAGCCTGCGGCTG TCCTGTGCTGCCTCTGGCTTCACCATCTCCACCAATGCCATGTCCTGGGTGCGCCAGGCCCCTGGCAAGGGCCTGGA GTGGATTGGAGTCATCACTGGCAGAGACATCACCTACTATGCCTCCTGGGCCAAAGGCCGCTTCACCATCTCCAGAG ACAACAGCAAGAACACCCTGTACCTGCAGATGAGCAGCCTGCGCAGTGAGGACACAGCTGTGTACTACTGTGCCCGA GATGGAGGCAGCAGTGCCATCACCTCCAACAACATCTGGGGCCAGGGCACCCTGGTCACTGTGTCCTCTGCTAGCAC CAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGG TGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCT GCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGAC CTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGA CCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAG GACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAA GTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCT ACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAAC AAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCT GCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACA TTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGC TCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCAT GCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 103: SI-75X4 Chain B Amino Acid Sequence QVQLVQSGGGLVQAGGSLSLSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKN TLYLQMDSLKPEDTAVYYCAADLQYGSSWPQRSSAEYDYWGQGTTVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGD RVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYF ISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQ DSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKP KDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVS NKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSD GSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG >Sequence ID 104: SI-75X4 Chain B Nucleotide Sequence CAGGTGCAGCTGGTGCAGTCTGGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGG CCGCACCTTCTCCATGTACACCATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACA GAGGCAGAGGCCTGAGCCCAGACATTGCTGACTCTGTGAATGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAAC ACCCTGTACCTGCAGATGGACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGG CAGCAGCTGGCCTCAGAGGAGCTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTCTCGAGCGGAG GAGGAGGCTCTGGAGGAGGAGGCAGTGATGTGGTGATGACCCAGAGCCCCTCCACCCTGTCTGCCTCTGTGGGAGAC AGAGTGACCATCAACTGCCAGGCCAGTGAGAGCATCTCCTCCTGGCTGGCCTGGTACCAGCAGAAGCCAGGCAAGGC CCCCAAGCTGCTCATCTATGAAGCCTCCAAGCTGGCCTCTGGAGTGCCCTCCCGCTTCTCTGGCTCTGGCTCTGGCA CAGAGTTCACCCTGACCATCTCCAGCCTGCAGCCAGATGACTTTGCCACCTACTACTGCCAGGGCTACTTCTACTTC ATCTCCAGGACCTATGTGAACAGCTTTGGAGGAGGCACCAAGGTGGAGATCAAGCGTACGGTGGCTGCCCCCTCTGT GTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACC CCAGAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAG GACAGCAAGGACAGCACCTACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTA TGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACA AGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCC AAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGT GAAGTTCAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCA CCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCC AACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACAC CCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTG ACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGAT GGCTCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGT CATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 105: SI-75X17 Chain A Amino Acid Sequence EVQLQESGGGLVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKN TVYLQMNSLKPEDTAVYYCAAALGVLVLAPGNVYSYWGQGTQVTVSSGGGGSGGGGSQVQLQESGGRLVQPGEPLSL TCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGG YSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSG LYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISR TPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPI EKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 106: SI-75X17 Chain A Nucleotide Sequence GAGGTGCAGCTGCAGGAGTCTGGCGGCGGCCTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGG CCGCTCCTTCAACTCCTACACCATGGGCTGGTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCC TGTGGAGTGGCCCCACCACCTACTATGCTGACTCTGTGAAGGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAAC ACTGTGTACCTGCAGATGAACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCT GGTGCTGGCCCCTGGCAATGTGTACAGCTACTGGGGCCAGGGCACCCAGGTGACTGTCTCGAGCGGCGGTGGAGGGT CCGGCGGTGGTGGATCACAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTG ACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGA GTGGATCGGAGTTATCTTCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGA GCACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGG TACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCC TCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGC CTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGC CTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCA CAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCC CAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGG ACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGG AGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGA CTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATT GAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCT GACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCA ATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAG CTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCA CTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 107: SI-75X17 Chain B Amino Acid Sequence QVQLVQSGGGLVQAGGSLSLSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKN TLYLQMDSLKPEDTAVYYCAADLQYGSSWPQRSSAEYDYWGQGTTVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQ RVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARD SGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKD TLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGS FFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG >Sequence ID 108: SI-75X17 Chain B Nucleotide Sequence CAGGTGCAGCTGGTGCAGTCTGGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGG CCGCACCTTCTCCATGTACACCATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACA GAGGCAGAGGCCTGAGCCCAGACATTGCTGACTCTGTGAATGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAAC ACCCTGTACCTGCAGATGGACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGG CAGCAGCTGGCCTCAGAGGAGCTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTCTCGAGTGGCG GTGGAGGGTCCGGCGGTGGTGGATCAGATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAG AGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGG TAAACCTCCTAAACTCCTTATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTT CCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGAT TCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCAT CTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAG AAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGC AAGGACAGCACCTACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTG TGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCC ACACCTGCCCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGAC ACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTT CAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACC GAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAG GCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCC TCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTG CTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCC TTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCA TGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 109: SI-75X19 Chain A Amino Acid Sequence QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVY LKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAA GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQD WLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQLQESGGG LVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKNTVYLQMNSLK PEDTAVYYCAAALGVLVLAPGNVYSYWGQGTQVTVSS >Sequence ID 110: SI-75X19 Chain A Nucleotide Sequence CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGG CATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCT TCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTAT TTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTG GGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCA AGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGG AACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTC TGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCA AGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCT GGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTG TGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATG CCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGAC TGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAA GGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGT CCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAAC AACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAG CCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCC TGAGCCTGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAGGATCCGAGGTGCAGCTGCAGGAGTCTGGCGGCGGC CTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGGCCGCTCCTTCAACTCCTACACCATGGGCTG GTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCCTGTGGAGTGGCCCCACCACCTACTATGCTG ACTCTGTGAAGGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAACACTGTGTACCTGCAGATGAACAGCCTGAAG CCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCTGGTGCTGGCCCCTGGCAATGTGTACAGCTA CTGGGGCCAGGGCACCCAGGTGACTGTGTCTAGCTGA >Sequence ID 111: SI-75X19 Chain B Amino Acid Sequence DPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTI TRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVD NALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAP EAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVL HQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQ PENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSQVQLVQS GGGLVQAGGSLSLSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKNTLYLQMD SLKPEDTAVYYCAADLQYGSSWPQRSSAEYDYWGQGTTVTVSS >Sequence ID 112: SI-75X19 Chain B Nucleotide Sequence GATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAG CCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACT CAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATC ACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGG TGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGA AGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGAC AATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTC CACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCA GCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCA GAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGA AGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAG TGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTG CACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGAC CATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGA ACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAG CCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGT GGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCC AGAAGAGCCTGAGCCTGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAGGATCCCAGGTGCAGCTGGTGCAGTCT GGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGGCCGCACCTTCTCCATGTACAC CATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACAGAGGCAGAGGCCTGAGCCCAG ACATTGCTGACTCTGTGAATGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAACACCCTGTACCTGCAGATGGAC AGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGGCAGCAGCTGGCCTCAGAGGAG CTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTGTCTAGCTGA >Sequence ID 113: SI-75X9 Chain A Amino Acid Sequence QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVY LKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAA GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQD WLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 114: SI-75X9 Chain A Nucleotide Sequence CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGG CATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCT TCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTAT TTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTG GGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCA AGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGG AACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTC TGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCA AGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCT GGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTG TGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATG CCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGAC TGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAA GGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGT CCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAAC AACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAG CCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCC TGAGCCTGAGCCCTGGATGA >Sequence ID 115: SI-75X9 Chain B Amino Acid Sequence QVQLVQSGGGLVQAGGSLSLSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKN TLYLQMDSLKPEDTAVYYCAADLQYGSSWPQRSSAEYDYWGQGTTVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQ RVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARD SGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKD TLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNK ALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGS FFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG >Sequence ID 116: SI-75X9 Chain B Nucleotide Sequence CAGGTGCAGCTGGTGCAGTCTGGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGG CCGCACCTTCTCCATGTACACCATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACA GAGGCAGAGGCCTGAGCCCAGACATTGCTGACTCTGTGAATGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAAC ACCCTGTACCTGCAGATGGACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGG CAGCAGCTGGCCTCAGAGGAGCTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTCTCGAGTGGCG GTGGAGGGTCCGGCGGTGGTGGATCAGATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAG AGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGG TAAACCTCCTAAACTCCTTATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTT CCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGAT TCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCAT CTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAG AAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGC AAGGACAGCACCTACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTG TGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCC ACACCTGCCCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGAC ACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTT CAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACC GAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAG GCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCC TCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTG CTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCC TTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCA TGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 117: SI-75X11 Chain A Amino Acid Sequence EVQLQESGGGLVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKN TVYLQMNSLKPEDTAVYYCAAALGVLVLAPGNVYSYWGQGTQVTVSSGGGGSGGGGSQVQLQESGGRLVQPGEPLSL TCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGG YSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSG LYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISR TPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPI EKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSK LTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 118: SI-75X11 Chain A Nucleotide Sequence GAGGTGCAGCTGCAGGAGTCTGGCGGCGGCCTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGG CCGCTCCTTCAACTCCTACACCATGGGCTGGTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCC TGTGGAGTGGCCCCACCACCTACTATGCTGACTCTGTGAAGGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAAC ACTGTGTACCTGCAGATGAACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCT GGTGCTGGCCCCTGGCAATGTGTACAGCTACTGGGGCCAGGGCACCCAGGTGACTGTCTCGAGCGGCGGTGGAGGGT CCGGCGGTGGTGGATCACAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTG ACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGA GTGGATCGGAGTTATCTTCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGA GCACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGG TACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCC TCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGC CTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGC CTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCA CAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCC CAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGG ACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGG AGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGA CTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATT GAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCT GACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCA ATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAG CTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCA CTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 119: SI-75X11 Chain B Amino Acid Sequence DPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTI TRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVD NALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAP EAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVL HQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQ PENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG >Sequence ID 120: SI-75X11 Chain B Nucleotide Sequence GATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAG CCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACT CAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATC ACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGG TGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGA AGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGAC AATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTC CACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCA GCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCA GAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGA AGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAG TGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTG CACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGAC CATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGA ACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAG CCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGT GGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCC AGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 121: SI-75X15 Chain A Amino Acid Sequence QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVY LKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAA GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQD WLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 122: SI-75X15 Chain A Nucleotide Sequence CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGG CATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCT TCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTAT TTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTG GGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCA AGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGG AACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTC TGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCA AGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCT GGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTG TGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATG CCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGAC TGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAA GGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGT CCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAAC AACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAG CCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCC TGAGCCTGAGCCCTGGATGA >Sequence ID 123: SI-75X15 Chain B Amino Acid Sequence DPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTI TRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVD NALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAP EAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVL HQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQ PENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSQVQLVQS GGGLVQAGGSLSLSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKNTLYLQMD SLKPEDTAVYYCAADLQYGSSWPQRSSAEYDYWGQGTTVTVSS >Sequence ID 124: SI-75X15 Chain B Amino Acid Sequence GATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAG CCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACT CAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATC ACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGG TGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGA AGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGAC AATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTC CACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCA GCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCA GAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGA AGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAG TGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTG CACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGAC CATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGA ACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAG CCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGT GGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCC AGAAGAGCCTGAGCCTGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAGGATCCCAGGTGCAGCTGGTGCAGTCT GGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGGCCGCACCTTCTCCATGTACAC CATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACAGAGGCAGAGGCCTGAGCCCAG ACATTGCTGACTCTGTGAATGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAACACCCTGTACCTGCAGATGGAC AGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGGCAGCAGCTGGCCTCAGAGGAG CTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTGTCTAGCTGA >Sequence ID 125: SI-75X13 Chain A Amino Acid Sequence QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVY LKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAA GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQD WLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQLQESGGG LVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKNTVYLQMNSLK PEDTAVYYCAAALGVLVLAPGNVYSYWGQGTQVTVSS >Sequence ID 126: SI-75X13 Chain A Nucleotide Sequence CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGG CATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCT TCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTAT TTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTG GGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCA AGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGG AACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTC TGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCA AGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCT GGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTG TGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATG CCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGAC TGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAA GGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGT CCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAAC AACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAG CCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCC TGAGCCTGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAGGATCCGAGGTGCAGCTGCAGGAGTCTGGCGGCGGC CTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGGCCGCTCCTTCAACTCCTACACCATGGGCTG GTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCCTGTGGAGTGGCCCCACCACCTACTATGCTG ACTCTGTGAAGGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAACACTGTGTACCTGCAGATGAACAGCCTGAAG CCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCTGGTGCTGGCCCCTGGCAATGTGTACAGCTA CTGGGGCCAGGGCACCCAGGTGACTGTGTCTAGCTGA >Sequence ID 127: SI-75X13 Chain B Amino Acid Sequence DPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTI TRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVD NALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAP EAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVL HQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQ PENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG >Sequence ID 128: SI-75X13 Chain B Nucleotide Sequence GATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAG CCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACT CAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATC ACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGG TGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGA AGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGAC AATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTC CACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCA GCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCA GAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGA AGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAG TGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTG CACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGAC CATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGA ACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAG CCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGT GGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCC AGAAGAGCCTGAGCCTGAGCCCTGGATGA >Sequence ID 129: SI-38P11 Chain A Amino Acid Sequence QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRV EAEDAATYYCQQWTSNPPTFGGGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQPGAELVKPGASVKMSCKASGYT FTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGD WYFNVWGAGTTVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVI TGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSV FPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRD ELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALH NHYTQKSLSLSPGGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANL ASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGSGGGGS EVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNT VDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS >Sequence ID 130: SI-38P11 Chain A Nucleotide Sequence CAGATCGTGCTGAGCCAGAGCCCCGCCATCCTGAGCGCCAGCCCCGGCGAGAAGGTGACCATGACCTGCCGGGCCAG CAGCAGCGTGAGCTACATCCACTGGTTCCAGCAGAAGCCCGGCAGCAGCCCCAAGCCCTGGATCTACGCCACCAGCA ACCTGGCCAGCGGCGTGCCCGTGCGGTTCAGCGGCAGCGGCAGCGGCACCAGCTACAGCCTGACCATCAGCCGGGTG GAGGCCGAGGACGCCGCCACCTACTACTGCCAGCAGTGGACCAGCAACCCCCCCACCTTCGGCGGCGGCACCAAGCT GACCGTGCTGGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTGC AGCTGCAGCAGCCCGGCGCCGAGCTGGTGAAGCCCGGCGCCAGCGTGAAGATGAGCTGCAAGGCCAGCGGCTACACC TTCACCAGCTACAACATGCACTGGGTGAAGCAGACCCCCGGCCGGGGCCTGGAGTGGATCGGCGCCATCTACCCCGG CAACGGCGACACCAGCTACAACCAGAAGTTCAAGGGCAAGGCCACCCTGACCGCCGACAAGAGCAGCAGCACCGCCT ACATGCAGCTGAGCAGCCTGACCAGCGAGGACAGCGCCGTGTACTACTGCGCCCGGAGCACCTACTACGGCGGCGAC TGGTACTTCAACGTGTGGGGCGCCGGCACCACCGTGACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATC AGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTG GATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATT ACTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACAC GCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTG CTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTC TTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCT CAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTG AATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTG GACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGAT GAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGA GAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCAC AACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGT GATGACGCAGTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATA TTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTG GCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGATCTCCGATTTGGAACC AGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAA CAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGGGGTGGAGGTTCC GAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGG GTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAA GCTCTGGTGGTAACGTCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACG GTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGA CCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA >Sequence ID 131: SI-38P11 Chain B Amino Acid Sequence ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSM EPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGGSGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFS LSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSY YFDYWGQGTLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEAS KLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQ LKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGL SSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGV EVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELT KNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRF TQKSLSLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASG VPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEVQL LESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 132: SI-38P11 Chain B Nucleotide Sequence GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATC AAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCA AGCTGGCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATG GAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGT GACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTCA CATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCT CTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTG GTGGGACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAG TGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTAC TACTTTGATTATTGGGGGCAGGGGACTCTCGTCACGGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA CGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTG AGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCATCC AAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCT GCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCG GCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAG TTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGT GGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCA GCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTG AGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGC ACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCC CTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTG GAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGT CCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGA AAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACC AAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCA CCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACA GTCACCGTCTACGCTCTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCAC ACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGT GTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCAACCCGACGACTT CGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTG TGTTGGGAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCAATTG CTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAG TAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGT CTGCTGGTATAACATACGATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTG TACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTA TGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA >Sequence ID 133: SI-76PM1 Chain A Amino Acid Sequence QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRV EAEDAATYYCQQWTSNPPTFGGGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQPGAELVKPGASVKMSCKASGYT FTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGD WYFNVWGAGTTVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKCLEWIGVI TGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSV FPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRD ELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALH NHYTQKSLSLSPGGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANL ASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGSGGGGS EVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNT VDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS >Sequence ID 134: SI-76PM1 Chain A Nucleotide Sequence CAGATCGTGCTGAGCCAGAGCCCCGCCATCCTGAGCGCCAGCCCCGGCGAGAAGGTGACCATGACCTGCCGGGCCAG CAGCAGCGTGAGCTACATCCACTGGTTCCAGCAGAAGCCCGGCAGCAGCCCCAAGCCCTGGATCTACGCCACCAGCA ACCTGGCCAGCGGCGTGCCCGTGCGGTTCAGCGGCAGCGGCAGCGGCACCAGCTACAGCCTGACCATCAGCCGGGTG GAGGCCGAGGACGCCGCCACCTACTACTGCCAGCAGTGGACCAGCAACCCCCCCACCTTCGGCGGCGGCACCAAGCT GACCGTGCTGGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTGC AGCTGCAGCAGCCCGGCGCCGAGCTGGTGAAGCCCGGCGCCAGCGTGAAGATGAGCTGCAAGGCCAGCGGCTACACC TTCACCAGCTACAACATGCACTGGGTGAAGCAGACCCCCGGCCGGGGCCTGGAGTGGATCGGCGCCATCTACCCCGG CAACGGCGACACCAGCTACAACCAGAAGTTCAAGGGCAAGGCCACCCTGACCGCCGACAAGAGCAGCAGCACCGCCT ACATGCAGCTGAGCAGCCTGACCAGCGAGGACAGCGCCGTGTACTACTGCGCCCGGAGCACCTACTACGGCGGCGAC TGGTACTTCAACGTGTGGGGCGCCGGCACCACCGTGACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATC AGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTG GATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGTGTCTGGAGTGGATCGGAGTCATT ACTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACAC GCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTG CTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTC TTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCT CAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTG AATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTG GACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGAT GAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGA GAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCAC AACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGT GATGACGCAGTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATA TTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTG GCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGATCTCCGATTTGGAACC AGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAA CAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGGGGTGGAGGTTCC GAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGG GTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAA GCTCTGGTGGTAACGTCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACG GTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGA CCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA >Sequence ID 135: SI-76PM1 Chain B Amino Acid Sequence ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSM EPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGGSGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFS LSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSY YFDYWGQGTLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEAS KLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGCGTKVEIKRTVAAPSVFIFPPSDEQ LKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGL SSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGV EVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELT KNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRF TQKSLSLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASG VPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEVQL LESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRETISRDNSKNTL YLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 136: SI-76PM1 Chain B Nucleotide Sequence GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATC AAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCA AGCTGGCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATG GAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGT GACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTCA CATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCT CTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTG GTGGGACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAG TGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTAC TACTTTGATTATTGGGGGCAGGGGACTCTCGTCACGGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA CGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTG AGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCATCC AAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCT GCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCG GCTGTGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAG TTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGT GGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCA GCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTG AGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGC ACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCC CTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTG GAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGT CCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGA AAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACC AAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCA CCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACA GTCACCGTCTACGCTCTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCAC ACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGT GTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCAACCCGACGACTT CGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTG TGTTGGGAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCAATTG CTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAG TAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGT CTGCTGGTATAACATACGATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTG TACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTA TGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA >Sequence ID 137: SI-68X2 Chain A Amino Acid Sequence DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISS LQPEDIATYFCQHFDHLPLAFGCGTKVEIKGGGGSGGGGSGGGGSGGGGSQVQLQESGPGLVKPSETLSLTCTVSGG SVSSGDYYWTWIRQSPGKCLEWIGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTG AFDIWGQGTMVTVSTGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVIT GRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVF PLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDE LTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPGK >Sequence ID 138: SI-68X2 Chain A Nucleotide Sequence GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAG TCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAACTCCTGATCTACGATGCAT CCAATTTGGAAACAGGGGTCCCATCAAGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGC CTGCAGCCTGAAGATATTGCAACATATTTCTGTCAACACTTTGATCATCTCCCGCTCGCTTTCGGCTGTGGGACCAA GGTGGAAATTAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGG TGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGC TCCGTCAGCAGTGGTGATTACTACTGGACCTGGATCCGGCAGTCCCCAGGGAAGTGCCTGGAGTGGATTGGACACAT CTATTACAGTGGGAACACCAATTATAACCCCTCCCTCAAGAGCCGACTCACCATATCAATTGACACGTCCAAGACTC AGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCCATTTATTACTGTGTGCGAGATCGAGTGACTGGT GCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA GGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGAT TCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACT GGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCT GTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTA TTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTC CCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGA ACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAG GACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAAT CACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTG CCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCC GGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGAC GGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCT CACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCA TCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAG CTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAG CAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCA AGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAAC CACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATAG >Sequence ID 139: SI-68X2 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGCGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCA ASGFTFSSYWMSWVRQAPGKCLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSTGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIY EASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPS DEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRD ELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALH NHYTQKSLSLSPGK >Sequence ID 140: SI-68X2 Chain B Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CTGTGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCC AAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTAT GAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCAT CAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAA ATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCT GATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACA GTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCT ACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTG GACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGAT GAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGA GAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCAC AACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATAG >Sequence ID 141: SI-68E1 Chain A Amino Acid Sequence DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISS LQPEDIATYFCQHFDHLPLAFGCGTKVEIKGGGGSGGGGSGGGGSGGGGSQVQLQESGPGLVKPSETLSLTCTVSGG SVSSGDYYWTWIRQSPGKCLEWIGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTG AFDIWGQGTMVTVSTGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVIT GRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVF PLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDE LTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPGGGGGSGGGGSRSLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKCLEYIGTISSGGN VYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSSGGGGSGGGGSGGGGSGG GGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLT ISDLEPGDAATYYCQSTYLGTDYVGGAFGCGTKVEIK >Sequence ID 142: SI-68E1 Chain A Nucleotide Sequence GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAG TCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAACTCCTGATCTACGATGCAT CCAATTTGGAAACAGGGGTCCCATCAAGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGC CTGCAGCCTGAAGATATTGCAACATATTTCTGTCAACACTTTGATCATCTCCCGCTCGCTTTCGGCTGTGGGACCAA GGTGGAAATTAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGG TGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGC TCCGTCAGCAGTGGTGATTACTACTGGACCTGGATCCGGCAGTCCCCAGGGAAGTGCCTGGAGTGGATTGGACACAT CTATTACAGTGGGAACACCAATTATAACCCCTCCCTCAAGAGCCGACTCACCATATCAATTGACACGTCCAAGACTC AGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCCATTTATTACTGTGTGCGAGATCGAGTGACTGGT GCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA GGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGAT TCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACT GGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCT GTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTA TTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTC CCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGA ACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAG GACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAAT CACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTG CCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCC GGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGAC GGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCT CACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCA TCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAG CTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAG CAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCA AGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAAC CACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCGGTCGCTGGT GGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACTGCCTCTGGATTCACCATCAGTA GCTACCACATGCAGTGGGTCCGGCAGGCACCTGGGAAGTGCCTGGAGTACATCGGAACCATTAGTAGTGGTGGTAAT GTATACTACGCAAGCTCCGCTAGAGGCAGATTCACCATCTCCAGACCCTCGTCCAAGAACACGGTGGATCTTCAAAT GAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACTCTGGTTATAGTGATCCTATGTGGGGCC AGGGAACCCTGGTCACCGTCTCTTCAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGT GGAGGATCAGACGTTGTGATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCACCTG TCAGGCCAGTCAGAACATTAGGACTTACTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCT ATGCTGCAGCCAATCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACC ATCAGCGACTTGGAACCTGGCGATGCTGCAACTTACTATTGTCAGTCTACCTATCTTGGTACTGATTATGTTGGCGG TGCTTTCGGCTGTGGGACCAAGGTGGAGATCAAATGA >Sequence ID 143: SI-68E1 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGCGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCA ASGFTFSSYWMSWVRQAPGKCLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSTGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIY EASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPS DEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRD ELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALH NHYTQKSLSLSPGK >Sequence ID 144: SI-68E1 Chain B Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CTGTGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCC AAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTAT GAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCAT CAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAA ATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCT GATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACA GTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCT ACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTG GACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGAT GAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGA GAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCAC AACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATAG >Sequence ID 145: SI-68E2 Chain A Amino Acid Sequence DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISS LQPEDIATYFCQHFDHLPLAFGCGTKVEIKGGGGSGGGGSGGGGSGGGGSQVQLQESGPGLVKPSETLSLTCTVSGG SVSSGDYYWTWIRQSPGKCLEWIGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTG AFDIWGQGTMVTVSTGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVIT GRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVF PLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDE LTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPGK >Sequence ID 146: SI-68E2 Chain A Nucleotide Sequence GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAG TCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAACTCCTGATCTACGATGCAT CCAATTTGGAAACAGGGGTCCCATCAAGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGC CTGCAGCCTGAAGATATTGCAACATATTTCTGTCAACACTTTGATCATCTCCCGCTCGCTTTCGGCTGTGGGACCAA GGTGGAAATTAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGG TGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGC TCCGTCAGCAGTGGTGATTACTACTGGACCTGGATCCGGCAGTCCCCAGGGAAGTGCCTGGAGTGGATTGGACACAT CTATTACAGTGGGAACACCAATTATAACCCCTCCCTCAAGAGCCGACTCACCATATCAATTGACACGTCCAAGACTC AGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCCATTTATTACTGTGTGCGAGATCGAGTGACTGGT GCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA GGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGAT TCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACT GGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCT GTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTA TTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTC CCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGA ACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAG GACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAAT CACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTG CCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCC GGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGAC GGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCT CACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCA TCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAG CTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAG CAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCA AGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAAC CACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATAG >Sequence ID 147: SI-68E2 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGCGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCA ASGFTFSSYWMSWVRQAPGKCLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSTGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIY EASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPS DEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRD ELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALH NHYTQKSLSLSPGGGGGSGGGGSEVQLLESGGGLVQPGGSLRLSCAASGFSFSSGYDMCWVRQAPGKCLEWIACIAA GSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSSGGGGSGGGG SGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSG SGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGCGTKVEIK >Sequence ID 148: SI-68E2 Chain B Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CTGTGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCC AAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTAT GAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCAT CAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAA ATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCT GATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACA GTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCT ACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTG GACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGAT GAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGA GAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCAC AACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGAGGTGCA GCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCT TCAGTAGCGGGTACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGATCGCATGCATTGCTGCT GGTAGTGCTGGTATCACTTACGACGCGAACTGGGCGAAAGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACAC GCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCG ACTACGCCATGGACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGTCTGGTGGAGGCGGTTCAGGCGGAGGTGGA AGTGGTGGTGGCGGCTCTGGAGGCGGCGGATCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGT AGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAG GGAAAGCCCCTAAGCTCCTGATCTATAAGGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGA TCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTA TAGTTGGGGTAATGTTGATAATGTTTTCGGCTGCGGGACCAAGGTGGAGATCAAATAG >Sequence ID 149: SI-68P1 Chain A Amino Acid Sequence DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISS LQPEDIATYFCQHFDHLPLAFGCGTKVEIKGGGGSGGGGSGGGGSGGGGSQVQLQESGPGLVKPSETLSLTCTVSGG SVSSGDYYWTWIRQSPGKCLEWIGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTG AFDIWGQGTMVTVSTGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVIT GRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVF PLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVN HKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDE LTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPGGGGGSGGGGSRSLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKCLEYIGTISSGGN VYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSSGGGGSGGGGSGGGGSGG GGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLT ISDLEPGDAATYYCQSTYLGTDYVGGAFGCGTKVEIK >Sequence ID 150: SI-68P1 Chain A Nucleotide Sequence GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAG TCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAACTCCTGATCTACGATGCAT CCAATTTGGAAACAGGGGTCCCATCAAGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGC CTGCAGCCTGAAGATATTGCAACATATTTCTGTCAACACTTTGATCATCTCCCGCTCGCTTTCGGCTGTGGGACCAA GGTGGAAATTAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGG TGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGC TCCGTCAGCAGTGGTGATTACTACTGGACCTGGATCCGGCAGTCCCCAGGGAAGTGCCTGGAGTGGATTGGACACAT CTATTACAGTGGGAACACCAATTATAACCCCTCCCTCAAGAGCCGACTCACCATATCAATTGACACGTCCAAGACTC AGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCCATTTATTACTGTGTGCGAGATCGAGTGACTGGT GCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA GGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGAT TCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACT GGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCT GTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTA TTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTC CCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGA ACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAG GACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAAT CACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTG CCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCC GGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGAC GGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCT CACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCA TCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAG CTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAG CAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCA AGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAAC CACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCGGTCGCTGGT GGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACTGCCTCTGGATTCACCATCAGTA GCTACCACATGCAGTGGGTCCGGCAGGCACCTGGGAAGTGCCTGGAGTACATCGGAACCATTAGTAGTGGTGGTAAT GTATACTACGCAAGCTCCGCTAGAGGCAGATTCACCATCTCCAGACCCTCGTCCAAGAACACGGTGGATCTTCAAAT GAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACTCTGGTTATAGTGATCCTATGTGGGGCC AGGGAACCCTGGTCACCGTCTCTTCAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGT GGAGGATCAGACGTTGTGATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCACCTG TCAGGCCAGTCAGAACATTAGGACTTACTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCT ATGCTGCAGCCAATCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACC ATCAGCGACTTGGAACCTGGCGATGCTGCAACTTACTATTGTCAGTCTACCTATCTTGGTACTGATTATGTTGGCGG TGCTTTCGGCTGTGGGACCAAGGTGGAGATCAAATGA >Sequence ID 151: SI-68P1 Chain B Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGCGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCA ASGFTFSSYWMSWVRQAPGKCLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSTGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIY EASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPS DEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRD ELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALH NHYTQKSLSLSPGGGGGSGGGGSEVQLLESGGGLVQPGGSLRLSCAASGFSFSSGYDMCWVRQAPGKCLEWIACIAA GSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSSGGGGSGGGG SGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSG SGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGCGTKVEIK >Sequence ID 152: SI-68P1 Chain B Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CTGTGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCC AAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTAT GAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCAT CAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAA ATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCT GATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACA GTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCT ACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCAT CAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTG GACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGAT GAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGA GAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCAC AACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGAGGTGCA GCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCT TCAGTAGCGGGTACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGATCGCATGCATTGCTGCT GGTAGTGCTGGTATCACTTACGACGCGAACTGGGCGAAAGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACAC GCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCG ACTACGCCATGGACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGTCTGGTGGAGGCGGTTCAGGCGGAGGTGGA AGTGGTGGTGGCGGCTCTGGAGGCGGCGGATCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGT AGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAG GGAAAGCCCCTAAGCTCCTGATCTATAAGGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGA TCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTA TAGTTGGGGTAATGTTGATAATGTTTTCGGCTGCGGGACCAAGGTGGAGATCAAATAG >Sequence ID 153: SI-49R26 Chain A Amino Acid Sequence FLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHW MGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTVASTKGPSVFPLAPSS KSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT KVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHN AKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQV SLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKS LSLSPG >Sequence ID 154: SI-49R26 Chain A Nucleotide Sequence TTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCCTTGACTGAAAGCTATTGCGGCCCTTGTCCGAAAAACTG GATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGGCGTCTTGTATGA GTCAGAATGCCAGCCTGCTTAAGGTTTATTCAAAAGAAGACCAGGATCTGCTTAAGTTGGTAAAGAGCTACCACTGG ATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAAATCTCCTGAC GATCATCGAAATGCAGAAAGGGGACTGTGCCCTGTATGCATCATCCTTCAAGGGGTACATCGAGAACTGCAGTACCC CAAATACCTACATTTGTATGCAAAGAACGGTTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCC AAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTG GAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCA GCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACC AAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGC GGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACAT GCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAAT GCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGA CTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCA AAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTC AGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAA CAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGA GCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGC CTCTCCCTGTCTCCGGGTTAA >Sequence ID 155: SI-49R26 Chain B Amino Acid Sequence FLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHW MGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTVRTVAAPSVFIFPPSD EQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQ GLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDE LTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPG >Sequence ID 156: SI-49R26 Chain B Nucleotide Sequence TTCCTAAACTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCCATGTCCTAAAAACTG GATATGTTACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGT CTCAAAATGCCAGCCTTCTGAAAGTATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTGAAGTCATATCATTGG ATGGGACTAGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTCACCCAACCTACTAAC AATAATTGAAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGAGCTTTAAAGGCTATATAGAAAACTGTTCAACTC CAAATACGTACATCTGCATGCAAAGGACTGTGCGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGAT GAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTG GAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACA GCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAG GGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTG CCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCC GGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGAC GGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCT CACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCA TCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAG CTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAG CAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCA AGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAAC CACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTTAA >Sequence ID 157: SI-49R27 Chain A Amino Acid Sequence EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGCGTKLTVLGSTGSGSKPGSGEGSTKGEVQLVESGGGLVQPGGSLRLSCTA SGFTISTNAMSWVRQAPGKCLEWVGVITGRDITYYASWAKGRFTISRDTSKNTVYLQMNSLRAEDTAVYYCARDGGS SAITSNNIWGQGTLVTVSTGGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQA SCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIEN CSTPNTYICMQRTVASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLY SLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTP EVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEK TISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 158: SI-49R27 Chain A Nucleotide Sequence GAGATCGTGATGACACAATCTCCATCTACGCTCTCCGCCTCAGTGGGCGATAGAGTAATTATTACTTGTCAAGCCTC AGAGAGCATTTCATCATGGCTCGCCTGGTATCAGCAAAAGCCTGGGAAGGCCCCCAAACTTCTCATCTATGAAGCAT CAAAGCTGGCCTCTGGGGTTCCGTCTCGCTTCTCCGGGTCCGGCAGTGGTGCAGAGTTTACGTTGACTATATCTTCT TTGCAACCTGACGATTTCGCAACATATTATTGCCAGGGATACTTTTATTTTATTTCCCGAACATATGTTAACTCTTT TGGGTGCGGGACCAAACTCACTGTGCTGGGGTCTACCGGTAGTGGTTCTAAGCCTGGTTCAGGCGAAGGCAGTACGA AAGGGGAAGTGCAACTGGTCGAAAGCGGTGGAGGGCTTGTTCAACCTGGAGGAAGCCTCCGCTTGTCCTGCACGGCT AGCGGCTTTACAATAAGTACGAACGCCATGAGCTGGGTCCGGCAGGCTCCAGGTAAGTGTCTCGAATGGGTGGGGGT CATAACAGGCAGGGACATTACCTACTACGCCAGTTGGGCCAAGGGTCGATTTACCATTTCTAGAGATACATCCAAGA ACACGGTGTACCTCCAGATGAATTCTCTTAGGGCGGAAGACACAGCAGTATACTACTGCGCGCGAGATGGCGGGAGC AGTGCGATCACATCCAACAACATCTGGGGTCAGGGCACTCTTGTCACGGTGTCGACTGGCGGTGGAGGGTCCGGCGG TGGTGGATCATTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCCTTGACTGAAAGCTATTGCGGCCCTTGTC CGAAAAACTGGATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGGCG TCTTGTATGAGTCAGAATGCCAGCCTGCTTAAGGTTTATTCAAAAGAAGACCAGGATCTGCTTAAGTTGGTAAAGAG CTACCACTGGATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAA ATCTCCTGACGATCATCGAAATGCAGAAAGGGGACTGTGCCCTGTATGCATCATCCTTCAAGGGGTACATCGAGAAC TGCAGTACCCCAAATACCTACATTTGTATGCAAAGAACGGTTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTAC TCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCC CAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCAC CTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCT GAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAA ACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCTGACCAA GAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGC AGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCAAGCTCACC GTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACAC GCAGAAGAGCCTCTCCCTGTCTCCGGGTTAA >Sequence ID 159: SI-49R27 Chain B Amino Acid Sequence FLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHW MGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTVRTVAAPSVFIFPPSD EQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQ GLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDE LTKNQVSLWCLVKGEYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPG >Sequence ID 160: SI-49R27 Chain B Nucleotide Sequences TTCCTAAACTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCCATGTCCTAAAAACTG GATATGTTACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGT CTCAAAATGCCAGCCTTCTGAAAGTATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTGAAGTCATATCATTGG ATGGGACTAGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTCACCCAACCTACTAAC AATAATTGAAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGAGCTTTAAAGGCTATATAGAAAACTGTTCAACTC CAAATACGTACATCTGCATGCAAAGGACTGTGCGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGAT GAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTG GAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACA GCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAG GGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTG CCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCC GGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGAC GGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCT CACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCA TCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAG CTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAG CAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCA AGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAAC CACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTTAA >Sequence ID 161: SI-49R25 Chain A Amino Acid Sequence EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGCGTKLTVLGSTGSGSKPGSGEGSTKGEVQLVESGGGLVQPGGSLRLSCTA SGFTISTNAMSWVRQAPGKCLEWVGVITGRDITYYASWAKGRFTISRDTSKNTVYLQMNSLRAEDTAVYYCARDGGS SAITSNNIWGQGTLVTVSTGGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQA SCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIEN CSTPNTYICMQRTVASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLY SLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTP EVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEK TISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 162: SI-49R25 Chain A Nucleotide Sequence GAGATCGTGATGACACAATCTCCATCTACGCTCTCCGCCTCAGTGGGCGATAGAGTAATTATTACTTGTCAAGCCTC AGAGAGCATTTCATCATGGCTCGCCTGGTATCAGCAAAAGCCTGGGAAGGCCCCCAAACTTCTCATCTATGAAGCAT CAAAGCTGGCCTCTGGGGTTCCGTCTCGCTTCTCCGGGTCCGGCAGTGGTGCAGAGTTTACGTTGACTATATCTTCT TTGCAACCTGACGATTTCGCAACATATTATTGCCAGGGATACTTTTATTTTATTTCCCGAACATATGTTAACTCTTT TGGGTGCGGGACCAAACTCACTGTGCTGGGGTCTACCGGTAGTGGTTCTAAGCCTGGTTCAGGCGAAGGCAGTACGA AAGGGGAAGTGCAACTGGTCGAAAGCGGTGGAGGGCTTGTTCAACCTGGAGGAAGCCTCCGCTTGTCCTGCACGGCT AGCGGCTTTACAATAAGTACGAACGCCATGAGCTGGGTCCGGCAGGCTCCAGGTAAGTGTCTCGAATGGGTGGGGGT CATAACAGGCAGGGACATTACCTACTACGCCAGTTGGGCCAAGGGTCGATTTACCATTTCTAGAGATACATCCAAGA ACACGGTGTACCTCCAGATGAATTCTCTTAGGGCGGAAGACACAGCAGTATACTACTGCGCGCGAGATGGCGGGAGC AGTGCGATCACATCCAACAACATCTGGGGTCAGGGCACTCTTGTCACGGTGTCGACTGGCGGTGGAGGGTCCGGCGG TGGTGGATCATTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCCTTGACTGAAAGCTATTGCGGCCCTTGTC CGAAAAACTGGATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGGCG TCTTGTATGAGTCAGAATGCCAGCCTGCTTAAGGTTTATTCAAAAGAAGACCAGGATCTGCTTAAGTTGGTAAAGAG CTACCACTGGATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAA ATCTCCTGACGATCATCGAAATGCAGAAAGGGGACTGTGCCCTGTATGCATCATCCTTCAAGGGGTACATCGAGAAC TGCAGTACCCCAAATACCTACATTTGTATGCAAAGAACGGTTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTAC TCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCC CAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCAC CTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCT GAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAA ACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCTGACCAA GAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGC AGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCAAGCTCACC GTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACAC GCAGAAGAGCCTCTCCCTGTCTCCGGGTTAA >Sequence ID 163: SI-49R25 Chain B Amino Acid Sequence ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSM EPEDFATYYCFQGSVYPFTFGQGTKLEIKGSTGSGSKPGSGEGSTKGQVTLKESGPGLVQPGQTLRLTCAFSGFSLS TSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYF DYWGQGTLVTVSTGGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQN ASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNT YICMQRTVRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTP EVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEK TISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 164: SI-49R25 Chain B Nucleotide Sequence GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATC AAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCA AGCTGGCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATG GAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAATT GGAGATAAAGGGAAGTACTGGTTCTGGGTCTAAACCCGGTTCCGGCGAAGGTAGTACTAAAGGACAGGTCACATTGA AGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGGCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGC ACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGGTGGGA CGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACT TGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTACTACTTT GATTATTGGGGGCAGGGGACTCTCGTCACGGTGTCGACTGGCGGTGGAGGGTCCGGCGGTGGTGGATCATTCCTAAA CTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCCATGTCCTAAAAACTGGATATGTT ACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGTCTCAAAAT GCCAGCCTTCTGAAAGTATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTGAAGTCATATCATTGGATGGGACT AGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTCACCCAACCTACTAACAATAATTG AAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGAGCTTTAAAGGCTATATAGAAAACTGTTCAACTCCAAATACG TACATCTGCATGCAAAGGACTGTGCGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTT GAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGG ATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAG CTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCAC CTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCT GAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAA ACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACCAA GAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGC AGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACC GTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACAC GCAGAAGAGCCTCTCCCTGTCTCCGGGTTAA >Sequence ID 165: SI-49P_x Chain A Amino Acid Sequence EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGCGTKLTVLGSTGSGSKPGSGEGSTKGEVQLVESGGGLVQPGGSLRLSCTA SGFTISTNAMSWVRQAPGKCLEWVGVITGRDITYYASWAKGRFTISRDTSKNTVYLQMNSLRAEDTAVYYCARDGGS SAITSNNIWGQGTLVTVSTGGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQA SCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIEN CSTPNTYICMQRTVASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLY SLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTP EVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEK TISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 166: SI-49P_x Chain A Nucleotide Sequence GAGATCGTGATGACACAATCTCCATCTACGCTCTCCGCCTCAGTGGGCGATAGAGTAATTATTACTTGTCAAGCCTC AGAGAGCATTTCATCATGGCTCGCCTGGTATCAGCAAAAGCCTGGGAAGGCCCCCAAACTTCTCATCTATGAAGCAT CAAAGCTGGCCTCTGGGGTTCCGTCTCGCTTCTCCGGGTCCGGCAGTGGTGCAGAGTTTACGTTGACTATATCTTCT TTGCAACCTGACGATTTCGCAACATATTATTGCCAGGGATACTTTTATTTTATTTCCCGAACATATGTTAACTCTTT TGGGTGCGGGACCAAACTCACTGTGCTGGGGTCTACCGGTAGTGGTTCTAAGCCTGGTTCAGGCGAAGGCAGTACGA AAGGGGAAGTGCAACTGGTCGAAAGCGGTGGAGGGCTTGTTCAACCTGGAGGAAGCCTCCGCTTGTCCTGCACGGCT AGCGGCTTTACAATAAGTACGAACGCCATGAGCTGGGTCCGGCAGGCTCCAGGTAAGTGTCTCGAATGGGTGGGGGT CATAACAGGCAGGGACATTACCTACTACGCCAGTTGGGCCAAGGGTCGATTTACCATTTCTAGAGATACATCCAAGA ACACGGTGTACCTCCAGATGAATTCTCTTAGGGCGGAAGACACAGCAGTATACTACTGCGCGCGAGATGGCGGGAGC AGTGCGATCACATCCAACAACATCTGGGGTCAGGGCACTCTTGTCACGGTGTCGACTGGCGGTGGAGGGTCCGGCGG TGGTGGATCATTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCCTTGACTGAAAGCTATTGCGGCCCTTGTC CGAAAAACTGGATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGGCG TCTTGTATGAGTCAGAATGCCAGCCTGCTTAAGGTTTATTCAAAAGAAGACCAGGATCTGCTTAAGTTGGTAAAGAG CTACCACTGGATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAA ATCTCCTGACGATCATCGAAATGCAGAAAGGGGACTGTGCCCTGTATGCATCATCCTTCAAGGGGTACATCGAGAAC TGCAGTACCCCAAATACCTACATTTGTATGCAAAGAACGGTTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTAC TCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCC CAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCAC CTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCT GAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAA ACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCTGACCAA GAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGC AGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCAAGCTCACC GTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACAC GCAGAAGAGCCTCTCCCTGTCTCCGGGTTAA >Sequence ID 167: SI-49P_x Chain B Amino Acid Sequence ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSM EPEDFATYYCFQGSVYPFTFGQGTKLEIKGSTGSGSKPGSGEGSTKGQVTLKESGPGLVQPGQTLRLTCAFSGFSLS TSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYF DYWGQGTLVTVSTGGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQN ASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNT YICMQRTVRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTP EVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEK TISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQLLESGGGLVQPGGSLRLSCAASGFSFSSG YDMCWVRQAPGKCLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAM DLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAP KLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGCGTKVEIK >Sequence ID 168: SI-49P_x Chain B Nucleotide Sequence GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATC AAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCA AGCTGGCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATG GAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAATT GGAGATAAAGGGAAGTACTGGTTCTGGGTCTAAACCCGGTTCCGGCGAAGGTAGTACTAAAGGACAGGTCACATTGA AGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGGCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGC ACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGGTGGGA CGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACT TGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTACTACTTT GATTATTGGGGGCAGGGGACTCTCGTCACGGTGTCGACTGGCGGTGGAGGGTCCGGCGGTGGTGGATCATTCCTAAA CTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCCATGTCCTAAAAACTGGATATGTT ACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGTCTCAAAAT GCCAGCCTTCTGAAAGTATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTGAAGTCATATCATTGGATGGGACT AGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTCACCCAACCTACTAACAATAATTG AAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGAGCTTTAAAGGCTATATAGAAAACTGTTCAACTCCAAATACG TACATCTGCATGCAAAGGACTGTGCGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTT GAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGG ATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAG CTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCAC CTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCT GAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAA ACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACCAA GAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGC AGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACC GTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACAC GCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGAGGTGCAGCTGTTGGAGT CTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTAGCGGG TACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGATCGCATGCATTGCTGCTGGTAGTGCTGG TATCACTTACGACGCGAACTGGGCGAAAGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGC AAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCGACTACGCCATG GACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGTCTGGTGGAGGCGGTTCAGGCGGAGGTGGAAGTGGTGGTGG CGGCTCTGGAGGCGGCGGATCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAG TCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCT AAGCTCCTGATCTATAAGGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGA ATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTA ATGTTGATAATGTTTTCGGCTGCGGGACCAAGGTGGAGATCAAATAG >Sequence ID 169: SI-49P8 Chain A Amino Acid Sequence EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGCGTKLTVLGSTGSGSKPGSGEGSTKGEVQLVESGGGLVQPGGSLRLSCTA SGFTISTNAMSWVRQAPGKCLEWVGVITGRDITYYASWAKGRFTISRDTSKNTVYLQMNSLRAEDTAVYYCARDGGS SAITSNNIWGQGTLVTVSTGGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQA SCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIEN CSTPNTYICMQRTVASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLY SLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTP EVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEK TISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSRSLVESGGGLVQPGGSLRLSCTASGFTISSYH MQWVRQAPGKCLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGT LVTVSSGGGGSGGGGSGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAA ANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGCGTKVEIK >Sequence ID 170: SI-49P8 Chain A Nucleotide Sequence GAGATCGTGATGACACAATCTCCATCTACGCTCTCCGCCTCAGTGGGCGATAGAGTAATTATTACTTGTCAAGCCTC AGAGAGCATTTCATCATGGCTCGCCTGGTATCAGCAAAAGCCTGGGAAGGCCCCCAAACTTCTCATCTATGAAGCAT CAAAGCTGGCCTCTGGGGTTCCGTCTCGCTTCTCCGGGTCCGGCAGTGGTGCAGAGTTTACGTTGACTATATCTTCT TTGCAACCTGACGATTTCGCAACATATTATTGCCAGGGATACTTTTATTTTATTTCCCGAACATATGTTAACTCTTT TGGGTGCGGGACCAAACTCACTGTGCTGGGGTCTACCGGTAGTGGTTCTAAGCCTGGTTCAGGCGAAGGCAGTACGA AAGGGGAAGTGCAACTGGTCGAAAGCGGTGGAGGGCTTGTTCAACCTGGAGGAAGCCTCCGCTTGTCCTGCACGGCT AGCGGCTTTACAATAAGTACGAACGCCATGAGCTGGGTCCGGCAGGCTCCAGGTAAGTGTCTCGAATGGGTGGGGGT CATAACAGGCAGGGACATTACCTACTACGCCAGTTGGGCCAAGGGTCGATTTACCATTTCTAGAGATACATCCAAGA ACACGGTGTACCTCCAGATGAATTCTCTTAGGGCGGAAGACACAGCAGTATACTACTGCGCGCGAGATGGCGGGAGC AGTGCGATCACATCCAACAACATCTGGGGTCAGGGCACTCTTGTCACGGTGTCGACTGGCGGTGGAGGGTCCGGCGG TGGTGGATCATTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCCTTGACTGAAAGCTATTGCGGCCCTTGTC CGAAAAACTGGATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGGCG TCTTGTATGAGTCAGAATGCCAGCCTGCTTAAGGTTTATTCAAAAGAAGACCAGGATCTGCTTAAGTTGGTAAAGAG CTACCACTGGATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAA ATCTCCTGACGATCATCGAAATGCAGAAAGGGGACTGTGCCCTGTATGCATCATCCTTCAAGGGGTACATCGAGAAC TGCAGTACCCCAAATACCTACATTTGTATGCAAAGAACGGTTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTAC TCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCC CAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCAC CTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCT GAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAA ACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCTGACCAA GAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGC AGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCAAGCTCACC GTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACAC GCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCGGTCGCTGGTGGAGTCTG GGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACTGCCTCTGGATTCACCATCAGTAGCTACCAC ATGCAGTGGGTCCGGCAGGCACCTGGGAAGTGCCTGGAGTACATCGGAACCATTAGTAGTGGTGGTAATGTATACTA CGCAAGCTCCGCTAGAGGCAGATTCACCATCTCCAGACCCTCGTCCAAGAACACGGTGGATCTTCAAATGAACAGCC TGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACTCTGGTTATAGTGATCCTATGTGGGGCCAGGGAACC CTGGTCACCGTCTCTTCAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATC AGACGTTGTGATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCACCTGTCAGGCCA GTCAGAACATTAGGACTTACTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGCTGCA GCCAATCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCGA CTTGGAACCTGGCGATGCTGCAACTTACTATTGTCAGTCTACCTATCTTGGTACTGATTATGTTGGCGGTGCTTTCG GCTGTGGGACCAAGGTGGAGATCAAATGA >Sequence ID 171: SI-49P8 Chain B Amino Acid Sequence ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSM EPEDFATYYCFQGSVYPFTFGQGTKLEIKGSTGSGSKPGSGEGSTKGQVTLKESGPGLVQPGQTLRLTCAFSGFSLS TSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYF DYWGQGTLVTVSTGGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQN ASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNT YICMQRTVRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTP EVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEK TISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGEYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQLLESGGGLVQPGGSLRLSCAASGFSFSSG YDMCWVRQAPGKCLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAM DLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAP KLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGCGTKVEIK >Sequence ID 172: SI-49P8 Chain B Nucleotide Sequence GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATC AAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCA AGCTGGCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATG GAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAATT GGAGATAAAGGGAAGTACTGGTTCTGGGTCTAAACCCGGTTCCGGCGAAGGTAGTACTAAAGGACAGGTCACATTGA AGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGGCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGC ACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGGTGGGA CGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACT TGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTACTACTTT GATTATTGGGGGCAGGGGACTCTCGTCACGGTGTCGACTGGCGGTGGAGGGTCCGGCGGTGGTGGATCATTCCTAAA CTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCCATGTCCTAAAAACTGGATATGTT ACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGTCTCAAAAT GCCAGCCTTCTGAAAGTATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTGAAGTCATATCATTGGATGGGACT AGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTCACCCAACCTACTAACAATAATTG AAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGAGCTTTAAAGGCTATATAGAAAACTGTTCAACTCCAAATACG TACATCTGCATGCAAAGGACTGTGCGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTT GAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGG ATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAG CTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCAC CTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCT GAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAA ACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACCAA GAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGC AGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACC GTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACAC GCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGAGGTGCAGCTGTTGGAGT CTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTAGCGGG TACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGATCGCATGCATTGCTGCTGGTAGTGCTGG TATCACTTACGACGCGAACTGGGCGAAAGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGC AAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCGACTACGCCATG GACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGTCTGGTGGAGGCGGTTCAGGCGGAGGTGGAAGTGGTGGTGG CGGCTCTGGAGGCGGCGGATCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAG TCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCT AAGCTCCTGATCTATAAGGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGA ATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTA ATGTTGATAATGTTTTCGGCTGCGGGACCAAGGTGGAGATCAAATAG >Sequence ID 173: SI-49PM1 Chain A Amino Acid Sequence FLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHW MGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTVGGGGSGGGGSGGGGS GGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLV KSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTVVDGGGGSGGG GSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSK NTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDY FPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTC PPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKENWYVDGVEVHNAKTKPREEQYASTYRVV SVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVE WESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSR SLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKCLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVD LQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDVVMTQSPSSVSASVGDRVT ITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDY VGGAFGCGTKVEIK >Sequence ID 174: SI-49PM1 Chain A Nucleotide Sequence TTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCCTTGACTGAAAGCTATTGCGGCCCTTGTCCGAAAAACTG GATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGGCGTCTTGTATGA GTCAGAATGCCAGCCTGCTTAAGGTTTATTCAAAAGAAGACCAGGATCTGCTTAAGTTGGTAAAGAGCTACCACTGG ATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAAATCTCCTGAC GATCATCGAAATGCAGAAAGGGGACTGTGCCCTGTATGCATCATCCTTCAAGGGGTACATCGAGAACTGCAGTACCC CAAATACCTACATTTGTATGCAAAGAACGGTTGGAGGCGGTGGCTCAGGCGGAGGCGGCTCAGGAGGTGGCGGTTCA GGAGGCGGCGGATCTTTCCTAAACTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCC ATGTCCTAAAAACTGGATATGTTACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCC AGGCTTCTTGTATGTCTCAAAATGCCAGCCTTCTGAAAGTATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTG AAGTCATATCATTGGATGGGACTAGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTC ACCCAACCTACTAACAATAATTGAAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGAGCTTTAAAGGCTATATAG AAAACTGTTCAACTCCAAATACGTACATCTGCATGCAAAGGACTGTGGTCGACGGCGGTGGAGGGTCCGGCGGTGGT GGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGC CTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAG TCATTACTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAG AACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTC TTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCAT CGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTAC TTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACA GTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCA ACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGC CCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCAT GATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGT ACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCC AGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCC GGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAG TGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCT CGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTC TGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCGG TCGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACTGCCTCTGGATTCAC CATCAGTAGCTACCACATGCAGTGGGTCCGGCAGGCACCTGGGAAGTGCCTGGAGTACATCGGAACCATTAGTAGTG GTGGTAATGTATACTACGCAAGCTCCGCTAGAGGCAGATTCACCATCTCCAGACCCTCGTCCAAGAACACGGTGGAT CTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACTCTGGTTATAGTGATCCTAT GTGGGGCCAGGGAACCCTGGTCACCGTCTCTTCAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGT CCGGCGGTGGAGGATCAGACGTTGTGATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACC ATCACCTGTCAGGCCAGTCAGAACATTAGGACTTACTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCT CCTGATCTATGCTGCAGCCAATCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCA CTCTCACCATCAGCGACTTGGAACCTGGCGATGCTGCAACTTACTATTGTCAGTCTACCTATCTTGGTACTGATTAT GTTGGCGGTGCTTTCGGCTGTGGGACCAAGGTGGAGATCAAATGA >Sequence ID 175: SI-49PM1 Chain B Amino Acid Sequence ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSM EPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGGSGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFS LSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSY YFDYWGQGTLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEAS KLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQ LKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGL SSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGV EVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELT KNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRF TQKSLSLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASG VPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEVQL LESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTL YLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 176: SI-49PM1 Chain B Nucleotide Sequence GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATC AAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCA AGCTGGCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATG GAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGT GACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTCA CATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCT CTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTG GTGGGACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAG TGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTAC TACTTTGATTATTGGGGGCAGGGGACTCTCGTCACGGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA CGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTG AGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCATCC AAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCT GCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCG GCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAG TTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGT GGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCA GCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTG AGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGC ACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCC CTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTG GAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGT CCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGA AAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACC AAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCA CCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACA GTCACCGTCTACGCTCTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCAC ACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGT GTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCAACCCGACGACTT CGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTG TGTTGGGAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCAATTG CTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAG TAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGT CTGCTGGTATAACATACGATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTG TACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTA TGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA >Sequence ID 177: SI-49P9 Chain A Amino Acid EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGCGTKLTVLGSTGSGSKPGSGEGSTKGEVQLVESGGGLVQPGGSLRLSCTA SGFTISTNAMSWVRQAPGKCLEWVGVITGRDITYYASWAKGRFTISRDTSKNTVYLQMNSLRAEDTAVYYCARDGGS SAITSNNIWGQGTLVTVSTGGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQA SCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIEN CSTPNTYICMQRTVASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLY SLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTP EVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEK TISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSREGPELSPDDPAGLLDLRQGMFAQLVAQNVLL IDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAAL ALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLGSTGSGSK PGSGEGSTKGREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAK AGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGV HLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLGGGGSGGGGSREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLI DGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALA LTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGL >Sequence ID 178: SI-49P9 Chain A Nucleotide Sequence GAGATCGTGATGACACAATCTCCATCTACGCTCTCCGCCTCAGTGGGCGATAGAGTAATTATTACTTGTCAAGCCTC AGAGAGCATTTCATCATGGCTCGCCTGGTATCAGCAAAAGCCTGGGAAGGCCCCCAAACTTCTCATCTATGAAGCAT CAAAGCTGGCCTCTGGGGTTCCGTCTCGCTTCTCCGGGTCCGGCAGTGGTGCAGAGTTTACGTTGACTATATCTTCT TTGCAACCTGACGATTTCGCAACATATTATTGCCAGGGATACTTTTATTTTATTTCCCGAACATATGTTAACTCTTT TGGGTGCGGGACCAAACTCACTGTGCTGGGGTCTACCGGTAGTGGTTCTAAGCCTGGTTCAGGCGAAGGCAGTACGA AAGGGGAAGTGCAACTGGTCGAAAGCGGTGGAGGGCTTGTTCAACCTGGAGGAAGCCTCCGCTTGTCCTGCACGGCT AGCGGCTTTACAATAAGTACGAACGCCATGAGCTGGGTCCGGCAGGCTCCAGGTAAGTGTCTCGAATGGGTGGGGGT CATAACAGGCAGGGACATTACCTACTACGCCAGTTGGGCCAAGGGTCGATTTACCATTTCTAGAGATACATCCAAGA ACACGGTGTACCTCCAGATGAATTCTCTTAGGGCGGAAGACACAGCAGTATACTACTGCGCGCGAGATGGCGGGAGC AGTGCGATCACATCCAACAACATCTGGGGTCAGGGCACTCTTGTCACGGTGTCGACTGGCGGTGGAGGGTCCGGCGG TGGTGGATCATTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCCTTGACTGAAAGCTATTGCGGCCCTTGTC CGAAAAACTGGATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGGCG TCTTGTATGAGTCAGAATGCCAGCCTGCTTAAGGTTTATTCAAAAGAAGACCAGGATCTGCTTAAGTTGGTAAAGAG CTACCACTGGATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAA ATCTCCTGACGATCATCGAAATGCAGAAAGGGGACTGTGCCCTGTATGCATCATCCTTCAAGGGGTACATCGAGAAC TGCAGTACCCCAAATACCTACATTTGTATGCAAAGAACGGTTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGC ACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGA CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTAC TCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCC CAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCAC CTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCT GAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAA ACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCTGACCAA GAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGC AGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCAAGCTCACC GTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACAC GCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCGAGAGGGCCCCGAGCTGT CTCCTGATGACCCAGCAGGCCTCTTGGACTTGCGGCAGGGTATGTTCGCTCAACTTGTGGCTCAGAATGTTCTGCTC ATTGATGGACCACTCTCTTGGTATAGTGACCCCGGTCTGGCCGGGGTGAGTCTGACCGGCGGGCTCTCTTATAAAGA GGATACTAAGGAACTGGTCGTAGCAAAAGCGGGCGTTTATTACGTTTTTTTTCAGCTGGAGCTCAGGCGCGTGGTGG CCGGCGAGGGCAGTGGCTCTGTGTCCCTGGCCCTGCACTTACAGCCCTTGAGAAGCGCTGCAGGTGCTGCCGCACTG GCTTTAACTGTTGACCTCCCTCCGGCCTCTTCTGAAGCTAGAAACAGCGCTTTCGGCTTCCAAGGGCGCCTGCTGCA CCTGAGCGCAGGCCAGCGCTTAGGTGTGCACCTTCATACAGAGGCCAGGGCCCGACACGCTTGGCAGCTCACACAGG GTGCCACGGTTCTCGGACTTTTCCGCGTTACTCCCGAGATCCCCGCTGGCCTCGGAAGTACTGGTTCTGGGTCTAAA CCCGGTTCCGGCGAAGGTAGTACTAAAGGACGAGAAGGGCCAGAGTTAAGTCCAGATGACCCTGCTGGGCTTTTGGA CCTGCGGCAGGGCATGTTCGCTCAACTGGTGGCTCAGAACGTGCTGCTGATCGATGGCCCCCTGAGTTGGTACAGCG ATCCCGGGCTGGCAGGCGTGTCACTTACAGGGGGCCTCTCTTACAAGGAAGACACCAAGGAGTTAGTGGTCGCTAAG GCTGGCGTGTATTACGTGTTCTTCCAACTGGAGCTGAGAAGGGTTGTGGCAGGAGAGGGTAGCGGCAGCGTGTCTTT AGCCCTTCACTTGCAGCCCCTGAGGTCTGCTGCAGGTGCAGCCGCTCTCGCGCTCACCGTGGATCTCCCCCCAGCCT CATCTGAAGCTAGGAACAGTGCATTTGGCTTTCAGGGACGCTTGCTGCACCTCTCCGCTGGACAGAGGCTGGGCGTG CACCTTCACACAGAGGCCCGTGCCAGGCATGCATGGCAGCTCACTCAGGGGGCAACAGTGCTGGGTCTCTTCCGCGT GACTCCTGAAATACCAGCTGGACTTGGCGGTGGAGGCAGCGGCGGAGGAGGATCTCGTGAGGGGCCAGAACTGTCCC CCGATGACCCAGCCGGACTGCTCGATCTCAGACAGGGCATGTTCGCTCAGCTTGTAGCCCAAAATGTCCTCCTGATT GACGGCCCTTTGAGCTGGTATAGTGATCCCGGCTTGGCCGGGGTATCTCTGACCGGAGGCCTCTCCTACAAGGAAGA CACCAAAGAGCTGGTGGTGGCAAAAGCGGGGGTGTATTATGTGTTCTTTCAGCTCGAGCTGCGGAGAGTTGTGGCCG GGGAAGGGTCTGGGAGCGTATCTCTTGCACTTCACCTGCAGCCCCTGCGCAGCGCCGCTGGAGCCGCCGCCCTTGCT CTTACTGTGGATCTGCCTCCTGCTTCCTCAGAAGCACGCAACAGCGCCTTCGGCTTTCAAGGACGTCTCCTGCACTT GTCCGCAGGACAGAGGTTGGGCGTCCATTTACACACTGAGGCACGGGCACGGCACGCTTGGCAGCTTACCCAGGGAG CCACCGTGCTGGGACTCTTTAGAGTGACACCCGAGATCCCCGCTGGCTTGTAA >Sequence ID 179: SI-49P9 Chain B Amino Acid Sequence ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSM EPEDFATYYCFQGSVYPFTFGQGTKLEIKGSTGSGSKPGSGEGSTKGQVTLKESGPGLVQPGQTLRLTCAFSGFSLS TSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYF DYWGQGTLVTVSTGGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQN ASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNT YICMQRTVRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLS STLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTP EVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEK TISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLT VDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQLLESGGGLVQPGGSLRLSCAASGFSFSSG YDMCWVRQAPGKCLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAM DLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAP KLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGCGTKVEIK >Sequence ID 180: SI-49P9 Chain B Nucleotide Sequence GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATC AAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCA AGCTGGCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATG GAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAATT GGAGATAAAGGGAAGTACTGGTTCTGGGTCTAAACCCGGTTCCGGCGAAGGTAGTACTAAAGGACAGGTCACATTGA AGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGGCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGC ACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGGTGGGA CGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACT TGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTACTACTTT GATTATTGGGGGCAGGGGACTCTCGTCACGGTGTCGACTGGCGGTGGAGGGTCCGGCGGTGGTGGATCATTCCTAAA CTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCCATGTCCTAAAAACTGGATATGTT ACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGTCTCAAAAT GCCAGCCTTCTGAAAGTATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTGAAGTCATATCATTGGATGGGACT AGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTCACCCAACCTACTAACAATAATTG AAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGAGCTTTAAAGGCTATATAGAAAACTGTTCAACTCCAAATACG TACATCTGCATGCAAAGGACTGTGCGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTT GAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGG ATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGC AGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAG CTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCAC CTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCT GAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGA GGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCC TGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAA ACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACCAA GAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGC AGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACC GTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACAC GCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGAGGTGCAGCTGTTGGAGT CTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTAGCGGG TACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGATCGCATGCATTGCTGCTGGTAGTGCTGG TATCACTTACGACGCGAACTGGGCGAAAGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGC AAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCGACTACGCCATG GACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGTCTGGTGGAGGCGGTTCAGGCGGAGGTGGAAGTGGTGGTGG CGGCTCTGGAGGCGGCGGATCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAG TCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCT AAGCTCCTGATCTATAAGGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGA ATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTA ATGTTGATAATGTTTTCGGCTGCGGGACCAAGGTGGAGATCAAATAG >Sequence ID 181: SI-1C3 Heavy Chain Amino Acid Sequence QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGDYYWTWIRQSPGKGLEWIGHIYYSGNTNYNPSLKSRLTISIDTSK TQFSLKLSSVTAADTAIYYCVRDRVTGAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE PVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPC PAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVL TVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWES NGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK >Sequence ID 182: SI-1C3 Heavy Chain Nucleotide Sequence CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGG TGGCTCCGTCAGCAGTGGTGATTACTACTGGACCTGGATCCGGCAGTCCCCAGGGAAGGGACTGGAGTGGATTGGAC ACATCTATTACAGTGGGAACACCAATTATAACCCCTCCCTCAAGAGCCGACTCACCATATCAATTGACACGTCCAAG ACTCAGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCCATTTATTACTGTGTGCGAGATCGAGTGAC TGGTGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTCTCGAGCGCTAGCACCAAGGGCCCATCGGTCTTCC CCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAA CCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGG ACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATC ACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGC CCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCG GACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACG GCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTC ACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCAT CGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGAGGAGA TGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGC AATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAA GCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACC ACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA >Sequence ID 183: SI-1C3 Light Chain Amino Acid Sequence DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISS LQPEDIATYFCQHFDHLPLAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNAL QSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC >Sequence ID 184: SI-1C3 Light Chain Nucleotide Sequence GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAG TCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAACTCCTGATCTACGATGCAT CCAATTTGGAAACAGGGGTCCCATCAAGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGC CTGCAGCCTGAAGATATTGCAACATATTTCTGTCAACACTTTGATCATCTCCCGCTCGCTTTCGGCGGAGGGACCAA GGTGGAAATTAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAA CTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTC CAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGAC GCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCA CAAAGAGCTTCAACAGGGGAGAGTGTTAG >Sequence ID 185: SI-1C7 Amino Acid Sequence EPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPR EEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLV KGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG GGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGR FTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSQSALTQPASVS GSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADY YCSSYGSSSTHVIFGGGTKVTVL >Sequence ID 186: SI-1C7 Nucleotide Sequence GAGCCCAAATCTTCCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTT CCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGA GCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGG GAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGA GTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCC GAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTC AAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCC TCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGT GGCGGTGGAGGGTCCGGCGGTGGTGGATCCCAGGTGCAGCTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGG GTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAG GGAAGGGGCTGGAGTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGA TTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGT GTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGCG GTGGAGGCGGTTCAGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCCAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCT GGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTG GTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGTCTGATC GCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTAT TACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTATAA >Sequence ID 187: SI-9C21 Heavy Chain Amino Acid Sequence EVQLVESGGGLVQPGGSLRLSCTASGFTISTNAMSWVRQAPGKGLEWVGVITGRDITYYASWAKGRFTISRDTSKNT VYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFP EPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPP CPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSV LTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWE SNGQPENNYKTTPPVLDSDGSFLLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 188: SI-9C21 Heavy Chain Nucleotide Sequence GAAGTCCAATTGGTAGAAAGTGGCGGTGGTCTGGTGCAACCTGGTGGATCTCTTCGCCTCTCATGCACGGCTAGTGG CTTTACTATTTCAACTAATGCGATGAGCTGGGTTCGCCAGGCCCCCGGCAAAGGACTTGAGTGGGTCGGCGTCATCA CCGGCAGGGACATTACATACTATGCGAGTTGGGCAAAGGGCAGGTTCACGATTAGCCGCGATACTTCAAAGAATACC GTTTACCTTCAAATGAATAGCTTGCGCGCGGAAGACACAGCTGTGTATTACTGCGCGCGGGATGGAGGTAGTTCCGC CATAACTTCCAACAACATATGGGGACAAGGCACGCTGGTTACTGTGTCGTCAGCTAGCACCAAGGGCCCATCGGTCT TCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC GAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC AGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGA ATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCG TGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTC CCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGG ACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTC CTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCC CATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATG AGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAG AGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCCTGCTCTATAG CAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACA ACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTTGA >Sequence ID 189: SI-9C21 Light Chain Amino Acid Sequence EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGQGTKLTVLRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWK VDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC >Sequence ID 190: SI-9C21 Light Chain Nucleotide Sequence GAAATCGTTATGACGCAGAGTCCCTCCACGCTCTCCGCTAGTGTCGGGGATCGCGTCATTATCACATGCCAGGCCTC CGAGTCAATCAGCAGCTGGCTTGCATGGTATCAACAGAAGCCGGGAAAAGCTCCTAAATTGCTGATCTATGAAGCGT CAAAATTGGCGTCTGGTGTCCCATCTAGGTTCTCCGGCTCTGGGTCTGGTGCGGAATTTACTTTGACAATCTCCAGT CTTCAACCAGACGATTTCGCTACCTACTACTGCCAAGGGTATTTCTATTTTATAAGCCGGACATATGTAAACTCCTT CGGCCAAGGAACAAAGTTGACTGTTCTTCGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGC AGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCT CAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCC TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTAG >Sequence ID 191: SI-35FS11 Amino Acid Sequence EPKSSDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPR EEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLV KGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG GGGGSGGGGSRSLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFT ISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDVVMTQSPS SVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATY YCQSTYLGTDYVGGAFGGGTKVEIK >Sequence ID 192: SI-35FS11 Nucleotide Sequence GAGCCCAAATCTTCCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTT CCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGA GCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGG GAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGA GTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCC GAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTC AAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCC TCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGT GGCGGTGGAGGGTCCGGCGGTGGTGGATCCCGGTCGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTC CCTGAGACTCTCCTGTACTGCCTCTGGATTCACCATCAGTAGCTACCACATGCAGTGGGTCCGCCAGGCTCCAGGGA AGGGGCTGGAGTACATCGGAACCATTAGTAGTGGTGGTAATGTATACTACGCGAGCTCCGCGAGAGGCAGATTCACC ATCTCCAGACCCTCGTCCAAGAACACGGTGGATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTA CTGTGCGAGAGACTCTGGTTATAGTGATCCTATGTGGGGCCAGGGAACCCTGGTCACCGTCTCTTCAGGCGGTGGCG GTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCAGACGTTGTGATGACCCAGTCTCCATCT TCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCACCTGTCAGGCCAGTCAGAACATTAGGACTTACTTATCCTG GTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGCTGCAGCCAATCTGGCATCTGGGGTCCCATCAA GGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCGACCTGGAGCCTGGCGATGCTGCAACTTAC TATTGTCAGTCTACCTATCTTGGTACTGATTATGTTGGCGGTGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAATG A >Sequence ID 193: SI-3FS11 Amino Acid Sequence EPKSSDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPR EEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLV KGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG GGGGSGGGGSEVQLLESGGGLVQPGGSLRLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAK GRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDI QMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQ PDDFATYYCQQGYSWGNVDNVFGGGTKVEIK >Sequence ID 194: SI-3FS11 Nucleotide Sequence GAGCCCAAATCTTCCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTT CCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGA GCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGG GAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGA GTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCC GAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTC AAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCC TCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGA ACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGT GGCGGTGGAGGGTCCGGCGGTGGTGGATCCGAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGG GTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTAGCGGGTACGACATGTGCTGGGTCCGCCAGGCTC CAGGGAAGGGGCTGGAGTGGATCGCATGCATTGCTGCTGGTAGTGCTGGTATCACTTACGACGCGAACTGGGCGAAA GGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACAC GGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCGACTACGCCATGGACCTCTGGGGCCAGGGAACCCTGGTCA CCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGACATC CAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAG CATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATAAGGCATCCACTC TGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAG CCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTAATGTTGATAATGTTTTCGGCGGAGGGAC CAAGGTGGAGATCAAATAA >Sequence ID 195: SI-68X1 Chain A Amino Acid Sequence DIQMTQSPSTLSASVGDRVTITCQASENIYSNLAWYQQKPGKAPKLLIYDASTLASGVPSRFSGSGSGTEFTLTISS LQPDDFATYYCQSTYYNNIIYGAAFGCGTKVEIKGGGGSGGGGSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCA ASGFSFSGTQYVCWVRQAPGKCLEWIGCIYVDVANTYYATSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASH DTVCAGCGLDLWGQGTLVTVSTGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGL EWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSAS TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQ TYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV KFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCT LPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSV MHEALHNHYTQKSLSLSPGK >Sequence ID 196: SI-68X1 Chain A Nucleotide Sequence GACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAG TGAGAACATTTACAGCAATTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGATGCTT CCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGC CTGCAGCCTGATGATTTTGCAACTTATTACTGCCAATCTACTTATTATAATAATATCATTTATGGGGCTGCTTTCGG CTGTGGGACCAAGGTGGAGATCAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCA GCCTCTGGATTCTCCTTCAGTGGCACCCAGTACGTGTGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGAT CGGATGCATTTATGTGGATGTGGCTAACACTTACTACGCGACCTCCGTGAAGGGCAGATTCACCATCTCCAGAGACA ATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGTCAT GATACTGTTTGTGCTGGTTGTGGTTTGGACTTGTGGGGCCAGGGAACCCTGGTCACCGTGTCGACAGGCGGTGGAGG GTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGAC TCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTG GAGTGGATCGGAGTCATTACTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAG AGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGA GAGACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGC ACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCT GGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCC CGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAG ACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAA AACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCA AGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTC AAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCAC GTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCA ACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACC CTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGA CATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTG ATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA >Sequence ID 197: SI-68X1 Chain B Amino Acid Sequence DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISS LQPEDIATYFCQHFDHLPLAFGCGTKVEIKGGGGSGGGGSGGGGSGGGGSQVQLQESGPGLVKPSETLSLTCTVSGG SVSSGDYYWTWIRQSPGKCLEWIGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTG AFDIWGQGTMVTVSTGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEAS KLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQ LKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGL SSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGV EVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELT KNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHY TQKSLSLSPGK >Sequence ID 198: SI-68X1 Chain B Nucleotide Sequence GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAG TCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAACTCCTGATCTACGATGCAT CCAATTTGGAAACAGGGGTCCCATCAAGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGC CTGCAGCCTGAAGATATTGCAACATATTTCTGTCAACACTTTGATCATCTCCCGCTCGCTTTCGGCTGTGGGACCAA GGTGGAAATTAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGG TGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGC TCCGTCAGCAGTGGTGATTACTACTGGACCTGGATCCGGCAGTCCCCAGGGAAGTGCCTGGAGTGGATTGGACACAT CTATTACAGTGGGAACACCAATTATAACCCCTCCCTCAAGAGCCGACTCACCATATCAATTGACACGTCCAAGACTC AGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCCATTTATTACTGTGTGCGAGATCGAGTGACTGGT GCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGA CGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTG AGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCATCC AAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCT GCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCG GCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAG TTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGT GGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCA GCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTG AGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGC ACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCC CTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTG GAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGT CCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGA AAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACC AAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGG GCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCA CCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTAC ACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA >Sequence ID 199: SI-68X3 Chain A DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISS LQPEDFATYYCQQHYTTPPTFGQGTKVEIKGGGGSGGGGSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGF NIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGF YAMDYWGQGTLVTVSTGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVI TGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSV FPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYV DGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRD ELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALH NHYTQKSLSLSPGK >Sequence ID 200: SI-68X3 Chain A Nucleotide Sequence GACATCCAAATGACGCAGTCTCCCTCCAGTTTGAGTGCAAGTGTGGGAGACAGAGTTACGATCACATGTAGGGCAAG TCAGGACGTCAATACAGCCGTCGCATGGTACCAGCAGAAGCCTGGAAAGGCCCCGAAACTTCTGATTTACTCTGCAA GTTTCCTCTACAGTGGTGTTCCTAGTCGCTTCAGTGGGTCTCGGTCAGGCACCGATTTTACCCTGACAATTAGCAGC TTGCAACCGGAAGATTTTGCGACCTATTATTGCCAGCAACATTATACCACCCCTCCCACATTTGGACAAGGCACGAA GGTAGAGATTAAAGGCGGTGGAGGGAGCGGTGGAGGCGGTTCCGGTGGAGGTGGTTCTGGTGGAGGTGGCAGTGAAG TACAGCTTGTTGAGAGTGGTGGTGGACTTGTCCAACCAGGGGGAAGTCTGCGGCTGTCATGCGCAGCCTCTGGCTTC AACATTAAGGACACCTACATTCACTGGGTTCGGCAAGCGCCGGGGAAGGGGCTGGAATGGGTCGCCAGGATATACCC TACCAACGGGTACACCAGGTATGCAGATAGCGTTAAGGGTAGATTCACTATTTCAGCTGACACTAGCAAGAACACCG CGTATCTCCAGATGAACTCCCTTCGCGCCGAGGATACGGCTGTGTACTACTGCTCTAGGTGGGGAGGAGATGGGTTT TACGCAATGGATTACTGGGGACAGGGAACACTCGTTACGGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATC AGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTG GATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATT ACTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACAC GCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTG CTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTC TTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCC CGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCT CAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTG AATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACC GTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCT CCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTG GACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGT CCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCC CCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGAT GAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGA GAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGA GCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCAC AACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA >Sequence ID 201: SI-68X3 Chain B Amino Acid Sequence DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWK VDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCP APEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLT VLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESN GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK >Sequence ID 202: SI-68X3 Chain B Nucleotide Sequence GACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAG TGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCAT CCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGC CTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTT CGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGC AGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAG GTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCT CAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCC TGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCA GCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGAC CCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCG TGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACC GTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGA GAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGA CCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAAT GGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCT CACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACT ACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA >Sequence ID 203: αEGFR VH Amino Acid Sequence QVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQ VYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGTLVTVSS >Sequence ID 204: αEGFR VH Nucleotide Sequence CAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGG CTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTT GGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAA GTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGA TTACGAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCGAGC >Sequence ID 205: αEGFR VL Amino Acid Sequence EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISS VQSEDFAVYYCQQNNNWPTTFGPGTKLTVL >Sequence ID 206: αEGFR VL Nucleotide Sequence GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAG TCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAA GTGAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGT GTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAA GCTGACCGTTTTA >Sequence ID 207: αEGFR* VH Amino Acid Sequence QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGDYYWTWIRQSPGKGLEWIGHIYYSGNTNYNPSLKSRLTISIDTSK TQFSLKLSSVTAADTAIYYCVRDRVTGAFDIWGQGTMVTVSS >Sequence ID 208: αEGFR* VH Nucleotide Sequence CAAGTGCAACTCCAGGAGAGTGGGCCGGGATTGGTTAAACCGAGCGAGACCCTGAGTCTCACGTGTACAGTTTCAGG CGGGAGCGTGAGCTCAGGCGACTATTACTGGACATGGATAAGACAGAGTCCTGGAAAGGGCCTGGAGTGGATCGGTC ATATTTATTATTCAGGGAACACTAACTATAATCCATCTTTGAAATCCCGATTGACAATCTCTATCGATACCAGTAAA ACCCAGTTTAGCCTCAAGCTGTCCAGCGTTACTGCTGCAGACACAGCCATATACTATTGCGTACGCGATCGCGTGAC TGGAGCCTTCGACATATGGGGGCAGGGAACGATGGTAACAGTCTCGAGC >Sequence ID 209: αEGFR* VL Amino Acid Sequence DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISS LQPEDIATYFCQHFDHLPLAFGGGTKVEIK >Sequence ID 210: αEGFR* VL Nucleotide Sequence GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAG TCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAACTCCTGATCTACGATGCAT CCAATTTGGAAACAGGGGTCCCATCAAGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGC CTGCAGCCTGAAGATATTGCAACATATTTCTGTCAACACTTTGATCATCTCCCGCTCGCTTTCGGCGGAGGGACCAA GGTGGAAATTAAA >Sequence ID 211: αEGFR* VH Stapled Amino Acid Sequence QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGDYYWTWIRQSPGKCLEWIGHIYYSGNTNYNPSLKSRLTISIDTSK TQFSLKLSSVTAADTAIYYCVRDRVTGAFDIWGQGTMVTVST >Sequence ID 212: αEGFR* VH Stapled Nucleotide Sequence CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGG TGGCTCCGTCAGCAGTGGTGATTACTACTGGACCTGGATCCGGCAGTCCCCAGGGAAGTGCCTGGAGTGGATTGGAC ACATCTATTACAGTGGGAACACCAATTATAACCCCTCCCTCAAGAGCCGACTCACCATATCAATTGACACGTCCAAG ACTCAGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCCATTTATTACTGTGTGCGAGATCGAGTGAC TGGTGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTGTCGACA >Sequence ID 213: αEGFR* VL Stapled Amino Acid Sequence DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISS LQPEDIATYFCQHFDHLPLAFGGGTKVEIK >Sequence ID 214: αEGFR* VL Stapled Nucleotide Sequence GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAG TCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAACTCCTGATCTACGATGCAT CCAATTTGGAAACAGGGGTCCCATCAAGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGC CTGCAGCCTGAAGATATTGCAACATATTTCTGTCAACACTTTGATCATCTCCCGCTCGCTTTCGGCTGTGGGACCAA GGTGGAAATTAAA >Sequence ID 215: αCD19 VH Amino Acid Sequence QVTLKESGPGLVQPGQTLSLTCAFSGFSLSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSK NQVYLQMNSLDAEDTAVYYCARMELWSYYFDYWGQGTLVTVSS >Sequence ID 216: αCD19 VH Nucleotide Sequence CAGGTCACATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGG TTTTTCTCTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTC ACATTTGGTGGGACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAA AATCAAGTGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTG GTCTTACTACTTTGATTATTGGGGGCAGGGGACTCTCGTCACGGTCTCGAGC >Sequence ID 217: αCD19 VL Amino Acid Sequence ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSM EPEDFATYYCFQGSVYPFTFGQGTKVTVL >Sequence ID 218: αCD19 VL Nucleotide Sequence GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATC AAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCA AGCTGGCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATG GAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGT GACCGTCCTA >Sequence ID 219: αCD3 VH Amino Acid Sequence EVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNT LYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSS >Sequence ID 220: αCD3 VH Nucleotide Sequence GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGG ATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTA CTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACG CTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGC TATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCA >Sequence ID 221: αCD3 VL Amino Acid Sequence DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIK >Sequence ID 222: αCD3 VL Nucleotide Sequence GACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAG TGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCAT CCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGC CTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTT CGGCGGAGGGACCAAGGTGGAGATCAAA >Sequence ID 223: αCD3 VH stapled Amino Acid Sequence EVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKCLEWIGVITGRDITYYASWAKGRFTISRDNSKNT LYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSS >Sequence ID 224: αCD3 VH stapled Nucleotide Sequence GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGG ATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGTGTCTGGAGTGGATCGGAGTCATTA CTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACG CTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGC TATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCA >Sequence ID 225: αCD3 VL stapled Amino Acid Sequence DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGCGTKVEIK >Sequence ID 226: αCD3 VL stapled Nucleotide Sequence GACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAG TGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCAT CCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGC CTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTT CGGCTGTGGGACCAAGGTGGAGATCAAA >Sequence ID 227: αCD3* VH Amino Acid Sequence QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVY LKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSS >Sequence ID 228: αCD3* VH Nucleotide Sequence CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGG CATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCT TCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTAT TTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTG GGGGCAGGGTACACTGGTTACAGTTTCATCC >Sequence ID 229: αCD3* VL Amino Acid Sequence DPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTI TRVQSEDFATYYCSARDSGNIQSFGGGTRVEIK >Sequence ID 230: αCD3* VL Nucleotide Sequence GATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAG CCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACT CAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATC ACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGG TGGAACTCGGGTGGAGATAAAA >Sequence ID 231: αCD3** VH Amino Acid Sequence EVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWVGVITGRDITYYASWAKGRFTISRDTSKNT VYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSS >Sequence ID 232: αCD3** VH Nucleotide Sequence GAAGTCCAATTGGTAGAAAGTGGCGGTGGTCTGGTGCAACCTGGTGGATCTCTTCGCCTCTCATGCGCCGCTAGTGG CTTTACTATTTCAACTAATGCGATGAGCTGGGTTCGCCAGGCCCCCGGCAAAGGACTTGAGTGGGTCGGCGTCATCA CCGGCAGGGACATTACATACTATGCGAGTTGGGCAAAGGGCAGGTTCACGATTAGCCGCGATACTTCAAAGAATACC GTTTACCTTCAAATGAATAGCTTGAGGGCGGAAGACACAGCTGTGTATTACTGCGCGAGGGATGGAGGTAGTTCCGC CATAACTTCCAACAACATATGGGGACAAGGCACGCTGGTTACTGTCTCGAGT >Sequence ID 233: αCD3** VL Amino Acid Sequence EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISS LQPDDFATYYCQGYFYFISRTYVNSFGQGTKLTVL >Sequence ID 234: αCD3** VL Nucleotide Sequence GAAATCGTTATGACGCAGAGTCCCTCCACGCTCTCCGCTAGTGTCGGGGATCGCGTCATTATCACATGCCAGGCCTC CGAGTCAATCAGCAGCTGGCTTGCATGGTATCAACAGAAGCCGGGAAAAGCTCCTAAATTGCTGATCTATGAAGCGT CAAAATTGGCGTCTGGTGTCCCATCTAGGTTCTCCGGCTCTGGGTCTGGTGCGGAATTTACTTTGACAATCTCCAGT CTTCAACCAGACGATTTCGCTACCTACTACTGCCAAGGGTATTTCTATTTTATAAGCCGGACATATGTAAACTCCTT CGGCCAAGGAACAAAGTTGACTGTTCTT >Sequence ID 235: αCD3*** VH Amino Acid Sequence QQLLESGGRLIKPGATLRLTCKTSGFTISTNAMSWVRQPPGKGLEWIGVITGRDITYYASWAKGRFTISKTSINTVF LQMRSLRAEDTAVYYCARDGGSSAITSNNIWGRGTLVTVSS >Sequence ID 236: αCD3*** VH Nucleotide Sequence CAGCAGCTGCTGGAAAGCGGCGGCCGCCTGATTAAACCGGGCGCGACCCTGCGCCTGACCTGCAAAACCAGCGGCTT TACCATTAGCACCAACGCGATGAGCTGGGTGCGCCAGCCGCCGGGCAAAGGCCTGGAATGGATTGGCGTGATTACCG GCCGCGATATTACCTATTATGCGAGCTGGGCGAAAGGCCGCTTTACCATTAGCAAAACCAGCATTAACACCGTGTTT CTGCAGATGCGCAGCCTGCGCGCGGAAGATACCGCGGTGTATTATTGCGCGCGCGATGGCGGCAGCAGCGCGATTAC CAGCAACAACATTTGGGGCCGCGGCACCCTGGTGACCGTGAGCAGC >Sequence ID 237: αCD3*** VL Amino Acid Sequence DVQMTQSPSTLSATVGQRVTINCQASESISSWLAWYQQKPGQPPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISS LQSDDFATYYCQGYFYFISRTYVNSFGGGTRVEIK >Sequence ID 238: αCD3*** VL Nucleotide Sequence GATGTGCAGATGACCCAGAGCCCGAGCACCCTGAGCGCGACCGTGGGCCAGCGCGTGACCATTAACTGCCAGGCGAG CGAAAGCATTAGCAGCTGGCTGGCGTGGTATCAGCAGAAACCGGGCCAGCCGCCGAAACTGCTGATTTATGAAGCGA GCAAACTGGCGAGCGGCGTGCCGAGCCGCTTTAGCGGCAGCGGCAGCGGCACCGAATTTACCCTGACCATTAGCAGC CTGCAGAGCGATGATTTTGCGACCTATTATTGCCAGGGCTATTTTTATTTTATTAGCCGCACCTATGTGAACAGCTT TGGCGGCGGCACCCGCGTGGAAATTAAA >Sequence ID 239: αCD3**** VH Amino Acid Sequence QQLVESGGGLVKPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWVGVITGRDITYYASWAKGRFTISKTSKNTVY LQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSS >Sequence ID 240: αCD3**** VH Nucleotide Sequence CAGCAGCTGGTGGAAAGCGGCGGCGGCCTGGTGAAACCGGGCGGCAGCCTGCGCCTGAGCTGCGCGGCGAGCGGCTT TACCATTAGCACCAACGCGATGAGCTGGGTGCGCCAGGCGCCGGGCAAAGGCCTGGAATGGGTGGGCGTGATTACCG GCCGCGATATTACCTATTATGCGAGCTGGGCGAAAGGCCGCTTTACCATTAGCAAAACCAGCAAAAACACCGTGTAT CTGCAGATGAACAGCCTGCGCGCGGAAGATACCGCGGTGTATTATTGCGCGCGCGATGGCGGCAGCAGCGCGATTAC CAGCAACAACATTTGGGGCCAGGGCACCCTGGTGACCGTGAGCAGC >Sequence ID 241: αCD3**** VL Amino Acid Sequence DVVMTQSPSSLSASVGDRVTISCQASESISSWLAWYQQKPGQAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISS LEPEDFATYYCQGYFYFISRTYVNSFGGGTKVEIK >Sequence ID 242: αCD3**** VL Nucleotide Sequence GATGTGGTGATGACCCAGAGCCCGAGCAGCCTGAGCGCGAGCGTGGGCGATCGCGTGACCATTAGCTGCCAGGCGAG CGAAAGCATTAGCAGCTGGCTGGCGTGGTATCAGCAGAAACCGGGCCAGGCGCCGAAACTGCTGATTTATGAAGCGA GCAAACTGGCGAGCGGCGTGCCGAGCCGCTTTAGCGGCAGCGGCAGCGGCACCGAATTTACCCTGACCATTAGCAGC CTGGAACCGGAAGATTTTGCGACCTATTATTGCCAGGGCTATTTTTATTTTATTAGCCGCACCTATGTGAACAGCTT TGGCGGCGGCACCAAAGTGGAAATTAAA >Sequence ID 243: αPD-L1 VH Amino Acid Sequence EVQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNS KNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 244: αPD-L1 VH Nucleotide Sequence GAAGTGCAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGG TTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTA TCGCCGCCGGGTCTGCTGGTATAACATACGATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCA AAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATT TAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA >Sequence ID 245: αPD-L1 VL Amino Acid Sequence DIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISS LQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVL >Sequence ID 246: αPD-L1 VL Nucleotide Sequence GACATTCAGATGACACAGTCACCGTCTACGCTCTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTC CCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCAT CAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCC CTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGG GGGAACGAAAGTGACTGTGTTG >Sequence ID 247: α4-1BB VH Amino Acid Sequence EVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNT VDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS >Sequence ID 248: α4-1BB VH Nucleotide Sequence GAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGG GTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAA GCTCTGGTGGTAACGTCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACG GTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGA CCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCT >Sequence ID 249: α4-1BB VL Amino Acid Sequence DVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISD LEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVL >Sequence ID 250: α4-1BB VL Nucleotide Sequence GACGTTGTGATGACGCAGTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAG CCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTG CCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGATCTCCGAT TTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGG CGGAGGAACAAAACTCACTGTACTT >Sequence ID 251: 41BBL Amino Acid Sequence REGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQL ELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARH AWQLTQGATVLGLFRVTPEIPAGLGSTGSGSKPGSGEGSTKGREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDG PLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALT VDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLGGGGSGGGGSR EGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLE LRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHA WQLTQGATVLGLFRVTPEIPAGL >Sequence ID 252: 41BBL Nucleotide Sequence CGAGAGGGCCCCGAGCTGTCTCCTGATGACCCAGCAGGCCTCTTGGACTTGCGGCAGGGTATGTTCGCTCAACTTGT GGCTCAGAATGTTCTGCTCATTGATGGACCACTCTCTTGGTATAGTGACCCCGGTCTGGCCGGGGTGAGTCTGACCG GCGGGCTCTCTTATAAAGAGGATACTAAGGAACTGGTCGTAGCAAAAGCGGGCGTTTATTACGTTTTTTTTCAGCTG GAGCTCAGGCGCGTGGTGGCCGGCGAGGGCAGTGGCTCTGTGTCCCTGGCCCTGCACTTACAGCCCTTGAGAAGCGC TGCAGGTGCTGCCGCACTGGCTTTAACTGTTGACCTCCCTCCGGCCTCTTCTGAAGCTAGAAACAGCGCTTTCGGCT TCCAAGGGCGCCTGCTGCACCTGAGCGCAGGCCAGCGCTTAGGTGTGCACCTTCATACAGAGGCCAGGGCCCGACAC GCTTGGCAGCTCACACAGGGTGCCACGGTTCTCGGACTTTTCCGCGTTACTCCCGAGATCCCCGCTGGCCTCGGAAG TACTGGTTCTGGGTCTAAACCCGGTTCCGGCGAAGGTAGTACTAAAGGACGAGAAGGGCCAGAGTTAAGTCCAGATG ACCCTGCTGGGCTTTTGGACCTGCGGCAGGGCATGTTCGCTCAACTGGTGGCTCAGAACGTGCTGCTGATCGATGGC CCCCTGAGTTGGTACAGCGATCCCGGGCTGGCAGGCGTGTCACTTACAGGGGGCCTCTCTTACAAGGAAGACACCAA GGAGTTAGTGGTCGCTAAGGCTGGCGTGTATTACGTGTTCTTCCAACTGGAGCTGAGAAGGGTTGTGGCAGGAGAGG GTAGCGGCAGCGTGTCTTTAGCCCTTCACTTGCAGCCCCTGAGGTCTGCTGCAGGTGCAGCCGCTCTCGCGCTCACC GTGGATCTCCCCCCAGCCTCATCTGAAGCTAGGAACAGTGCATTTGGCTTTCAGGGACGCTTGCTGCACCTCTCCGC TGGACAGAGGCTGGGCGTGCACCTTCACACAGAGGCCCGTGCCAGGCATGCATGGCAGCTCACTCAGGGGGCAACAG TGCTGGGTCTCTTCCGCGTGACTCCTGAAATACCAGCTGGACTTGGCGGTGGAGGCAGCGGCGGAGGAGGATCTCGT GAGGGGCCAGAACTGTCCCCCGATGACCCAGCCGGACTGCTCGATCTCAGACAGGGCATGTTCGCTCAGCTTGTAGC CCAAAATGTCCTCCTGATTGACGGCCCTTTGAGCTGGTATAGTGATCCCGGCTTGGCCGGGGTATCTCTGACCGGAG GCCTCTCCTACAAGGAAGACACCAAAGAGCTGGTGGTGGCAAAAGCGGGGGTGTATTATGTGTTCTTTCAGCTCGAG CTGCGGAGAGTTGTGGCCGGGGAAGGGTCTGGGAGCGTATCTCTTGCACTTCACCTGCAGCCCCTGCGCAGCGCCGC TGGAGCCGCCGCCCTTGCTCTTACTGTGGATCTGCCTCCTGCTTCCTCAGAAGCACGCAACAGCGCCTTCGGCTTTC AAGGACGTCTCCTGCACTTGTCCGCAGGACAGAGGTTGGGCGTCCATTTACACACTGAGGCACGGGCACGGCACGCT TGGCAGCTTACCCAGGGAGCCACCGTGCTGGGACTCTTTAGAGTGACACCCGAGATCCCCGCTGGCTTGTGA >Sequence ID 253: NKG2D dimer Amino Acid Sequence FLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHW MGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTVGGGGSGGGGSGGGGS GGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLV KSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV >Sequence ID 254: NKG2D dimer Nucleotide Sequence TTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCCTTGACTGAAAGCTATTGCGGCCCTTGTCCGAAAAACTG GATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGGCGTCTTGTATGA GTCAGAATGCCAGCCTGCTTAAGGTTTATTCAAAAGAAGACCAGGATCTGCTTAAGTTGGTAAAGAGCTACCACTGG ATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAAATCTCCTGAC GATCATCGAAATGCAGAAAGGGGACTGTGCCCTGTATGCATCATCCTTCAAGGGGTACATCGAGAACTGCAGTACCC CAAATACCTACATTTGTATGCAAAGAACGGTTGGAGGCGGTGGCTCAGGCGGAGGCGGCTCAGGAGGTGGCGGTTCA GGAGGCGGCGGATCTTTCCTAAACTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCC ATGTCCTAAAAACTGGATATGTTACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCC AGGCTTCTTGTATGTCTCAAAATGCCAGCCTTCTGAAAGTATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTG AAGTCATATCATTGGATGGGACTAGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTC ACCCAACCTACTAACAATAATTGAAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGAGCTTTAAAGGCTATATAG AAAACTGTTCAACTCCAAATACGTACATCTGCATGCAAAGGACTGTG >Sequence ID 255: αHER3 VH Amino Acid Sequence QVQLQESGGGLVKPGGSLSLSCAASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKN SLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSS >Sequence ID 256: αHER3 VH Nucleotide Sequence CAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGG ATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAA ACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAAC TCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGG CTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGT >Sequence ID 257: αHER3 VL Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVL >Sequence ID 258: αHER3 VL Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CGGAGGGACCAAGGTGACCGTCCTA >Sequence ID 259: αCD20 VH Amino Acid Sequence QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSS TAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSS >Sequence ID 260: αCD20 VH Nucleotide Sequence CAGGTGCAGCTGCAGCAGCCCGGCGCCGAGCTGGTGAAGCCCGGCGCCAGCGTGAAGATGAGCTGCAAGGCCAGCGG CTACACCTTCACCAGCTACAACATGCACTGGGTGAAGCAGACCCCCGGCCGGGGCCTGGAGTGGATCGGCGCCATCT ACCCCGGCAACGGCGACACCAGCTACAACCAGAAGTTCAAGGGCAAGGCCACCCTGACCGCCGACAAGAGCAGCAGC ACCGCCTACATGCAGCTGAGCAGCCTGACCAGCGAGGACAGCGCCGTGTACTACTGCGCCCGGAGCACCTACTACGG CGGCGACTGGTACTTCAACGTGTGGGGCGCCGGCACCACCGTGACCGTCTCGAGC >Sequence ID 261: αCD20 VL Amino Acid Sequence QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRV EAEDAATYYCQQWTSNPPTFGGGTKLTVL >Sequence ID 262: αCD20 VL Nucleotide Sequence CAGATCGTGCTGAGCCAGAGCCCCGCCATCCTGAGCGCCAGCCCCGGCGAGAAGGTGACCATGACCTGCCGGGCCAG CAGCAGCGTGAGCTACATCCACTGGTTCCAGCAGAAGCCCGGCAGCAGCCCCAAGCCCTGGATCTACGCCACCAGCA ACCTGGCCAGCGGCGTGCCCGTGCGGTTCAGCGGCAGCGGCAGCGGCACCAGCTACAGCCTGACCATCAGCCGGGTG GAGGCCGAGGACGCCGCCACCTACTACTGCCAGCAGTGGACCAGCAACCCCCCCACCTTCGGCGGCGGCACCAAGCT GACCGTGCTG >Sequence ID 263: EGFR VHH Amino Acid Sequence EVQLQESGGGLVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKN TVYLQMNSLKPEDTAVYYCAAALGVLVLAPGNVYSYWGQGTQVTVSS >Sequence ID 264: EGFR VHH Nucleotide Sequence GAGGTGCAGCTGCAGGAGTCTGGCGGCGGCCTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGG CCGCTCCTTCAACTCCTACACCATGGGCTGGTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCC TGTGGAGTGGCCCCACCACCTACTATGCTGACTCTGTGAAGGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAAC ACTGTGTACCTGCAGATGAACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCT GGTGCTGGCCCCTGGCAATGTGTACAGCTACTGGGGCCAGGGCACCCAGGTGACTGTCTCGAGC >Sequence ID 265: HER3 VHH Amino Acid Sequence QVQLVQSGGGLVQAGGSLSLSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKN TLYLQMDSLKPEDTAVYYCAADLQYGSSWPQRSSAEYDYWGQGTTVTVSS >Sequence ID 266: HER3 VHH Nucleotide Sequence CAGGTGCAGCTGGTGCAGTCTGGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGG CCGCACCTTCTCCATGTACACCATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACA GAGGCAGAGGCCTGAGCCCAGACATTGCTGACTCTGTGAATGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAAC ACCCTGTACCTGCAGATGGACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGG CAGCAGCTGGCCTCAGAGGAGCTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTCTCGAGC >Sequence ID 267: αPD-L1 Stapled VH Amino Acid Sequence EVQLLESGGGLVQPGGSLRLSCAASGFSFSSGYDMCWVRQAPGKCLEWIACIAAGSAGITYDANWAKGRFTISRDNS KNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS >Sequence ID 268: αPD-L1 Stapled VH Nucleotide Sequence GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGG ATTCTCCTTCAGTAGCGGGTACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGATCGCATGCA TTGCTGCTGGTAGTGCTGGTATCACTTACGACGCGAACTGGGCGAAAGGCCGGTTCACCATCTCCAGAGACAATTCC AAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTT TTCGTTCGACTACGCCATGGACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGTCT >Sequence ID 269: αPD-L1 Stapled VL Amino Acid Sequence DIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISS LQPDDFATYYCQQGYSWGNVDNVFGCGTKVEIK >Sequence ID 270: αPD-L1 Stapled VL Nucleotide Sequence GACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAG TCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATAAGGCAT CCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGC CTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTAATGTTGATAATGTTTTCGGCTG CGGGACCAAGGTGGAGATCAAATAG >Sequence ID 271: α4-1BB VH Stapled Amino Acid Sequence RSLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKCLEYIGTISSGGNVYYASSARGRFTISRPSSKNTV DLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS >Sequence ID 272: α4-1BB VH Stapled Nucleotide Sequence CGGTCGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACTGCCTCTGGATT CACCATCAGTAGCTACCACATGCAGTGGGTCCGGCAGGCACCTGGGAAGTGCCTGGAGTACATCGGAACCATTAGTA GTGGTGGTAATGTATACTACGCAAGCTCCGCTAGAGGCAGATTCACCATCTCCAGACCCTCGTCCAAGAACACGGTG GATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACTCTGGTTATAGTGATCC TATGTGGGGCCAGGGAACCCTGGTCACCGTCTCTTCA >Sequence ID 273: α4-1BB VL Stapled Amino Acid Sequence DVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISD LEPGDAATYYCQSTYLGTDYVGGAFGCGTKVEIK >Sequence ID 274: α4-1BB VL Stapled Nucleotide Sequence GACGTTGTGATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCACCTGTCAGGCCAG TCAGAACATTAGGACTTACTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGCTGCAG CCAATCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCGAC TTGGAACCTGGCGATGCTGCAACTTACTATTGTCAGTCTACCTATCTTGGTACTGATTATGTTGGCGGTGCTTTCGG CTGTGGGACCAAGGTGGAGATCAAATGA >Sequence ID 275: αHer3 VH Stapled Amino Acid Sequence QVQLQESGGGLVKPGGSLRLSCAASGFTFSSYWMSWVRQAPGKCLEWVANINRDGSASYYVDSVKGRFTISRDDAKN SLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVST >Sequence ID 276: αHer3 VH Stapled Nucleotide Sequence CAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGG ATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGGTGGCCAACATAA ACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAAC TCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGG CTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTGTCGACA >Sequence ID 277: αHer3 VL Stapled Amino Acid Sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGCGTKVTVL >Sequence ID 278: αHer3 VL Stapled Nucleotide Sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CTGTGGGACCAAGGTGACCGTCCTA >Sequence ID 279: αCEA 656E11 VH Amino Acid Sequence EVQLVESGGGLVQPGGSLRLSCAASGFSFSGTQYVCWVRQAPGKGLEWIGCIYVDVANTYYATSVKGRFTISRDNSK NTLYLQMNSLRAEDTAVYYCASHDTVCAGCGLDLWGQGTLVTVSS >Sequence ID 280: αCEA 656E11 VH Nucleotide Sequence GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGG ATTCTCCTTCAGTGGCACCCAGTACGTGTGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGATGCA TTTATGTGGATGTGGCTAACACTTACTACGCGACCTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAG AACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGTCATGATACTGT TTGTGCTGGTTGTGGTTTGGACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGC >Sequence ID 281: αCEA 656E11 VL Amino Acid Sequence DIQMTQSPSTLSASVGDRVTITCQASENIYSNLAWYQQKPGKAPKLLIYDASTLASGVPSRFSGSGSGTEFTLTISS LQPDDFATYYCQSTYYNNIIYGAAFGGGTKVEIK >Sequence ID 282: αCEA 656E11 VL Nucleotide Sequence GACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAG TGAGAACATTTACAGCAATTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGATGCTT CCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGC CTGCAGCCTGATGATTTTGCAACTTATTACTGCCAATCTACTTATTATAATAATATCATTTATGGGGCTGCTTTCGG CGGAGGGACCAAGGTGGAGATCAAA >Sequence ID 283: αHER2 VH Amino Acid Sequence EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKN TAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVST >Sequence ID 284: αHER2 VH Nucleotide Sequence GAAGTACAGCTTGTTGAGAGTGGTGGTGGACTTGTCCAACCAGGGGGAAGTCTGCGGCTGTCATGCGCAGCCTCTGG CTTCAACATTAAGGACACCTACATTCACTGGGTTCGGCAAGCGCCGGGGAAGGGGCTGGAATGGGTCGCCAGGATAT ACCCTACCAACGGGTACACCAGGTATGCAGATAGCGTTAAGGGTAGATTCACTATTTCAGCTGACACTAGCAAGAAC ACCGCGTATCTCCAGATGAACTCCCTTCGCGCCGAGGATACGGCTGTGTACTACTGCTCTAGGTGGGGAGGAGATGG GTTTTACGCAATGGATTACTGGGGACAGGGAACACTCGTTACGGTGTCGACA >Sequence ID 285: αHER2 VL Amino Acid Sequence DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISS LQPEDFATYYCQQHYTTPPTFGQGTKVEIK >Sequence ID 286: αHER2 VL Nucleotide Sequence GACATCCAAATGACGCAGTCTCCCTCCAGTTTGAGTGCAAGTGTGGGAGACAGAGTTACGATCACATGTAGGGCAAG TCAGGACGTCAATACAGCCGTCGCATGGTACCAGCAGAAGCCTGGAAAGGCCCCGAAACTTCTGATTTACTCTGCAA GTTTCCTCTACAGTGGTGTTCCTAGTCGCTTCAGTGGGTCTCGGTCAGGCACCGATTTTACCCTGACAATTAGCAGC TTGCAACCGGAAGATTTTGCGACCTATTATTGCCAGCAACATTATACCACCCCTCCCACATTTGGACAAGGCACGAA GGTAGAGATTAAA >Sequence ID 287: SI-20C14 (anti-CEA 656E11) Heavy Chain Amino Acid Sequence EVQLVESGGGLVQPGGSLRLSCAASGFSFSGTQYVCWVRQAPGKGLEWIGCIYVDVANTYYATSVKGRFTISRDNSK NTLYLQMNSLRAEDTAVYYCASHDTVCAGCGLDLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDY FPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTC PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVV SVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE WESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG >Sequence ID 288: SI-20C14 (anti-CEA 656E11) Heavy Chain Nucleotide Sequence GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGG ATTCTCCTTCAGTGGCACCCAGTACGTGTGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGATGCA TTTATGTGGATGTGGCTAACACTTACTACGCGACCTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAG AACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGTCATGATACTGT TTGTGCTGGTTGTGGTTTGGACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCAAGGGCCCAT CGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTAC TTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACA GTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCA ACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGC CCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCAT GATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGT ACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTC AGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCC AGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCC GGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAG TGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCT CTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTC TGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTTAA >Sequence ID 289: SI-20C14 (anti-CEA 656E11) Light Chain Amino Acid Sequence DIQMTQSPSTLSASVGDRVTITCQASENIYSNLAWYQQKPGKAPKLLIYDASTLASGVPSRFSGSGSGTEFTLTISS LQPDDFATYYCQSTYYNNIIYGAAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKV DNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC >Sequence ID 290: SI-20C14 (anti-CEA 656E11) Light Chain Nucleotide Sequence GACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAG TGAGAACATTTACAGCAATTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGATGCTT CCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGC CTGCAGCCTGATGATTTTGCAACTTATTACTGCCAATCTACTTATTATAATAATATCATTTATGGGGCTGCTTTCGG CGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGT TGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTG GATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAG CAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGA GCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTAG >Sequence ID 291: αCD3***** VH Amino Acid Sequence QQLVESGGGLVKPGGSLRLSCAASGIDLSSNAIGWVRQAPGKGLEWVGVIFGSGNTYYASWAKGRFTISRSKNTVYL QMNSLRAEDTAVYYCARGGYSSDIWGQGTLVTVSS >Sequence ID 292: αCD3***** VH Nucleotide Sequence CAACAGTTGGTTGAGTCTGGTGGCGGTCTCGTTAAGCCTGGAGGGTCCCTTCGGCTTAGTTGTGCGGCCTCTGGGAT CGACCTGTCTAGCAACGCTATAGGATGGGTACGGCAAGCTCCGGGCAAAGGCCTTGAGTGGGTCGGCGTTATTTTTG GGAGCGGTAATACGTACTACGCCAGCTGGGCAAAAGGTAGGTTCACTATCAGTCGATCAAAGAACACGGTATATCTT CAGATGAACAGTCTCCGGGCGGAGGACACCGCGGTTTATTATTGCGCAAGGGGGGGATACTCCTCAGACATATGGGG CCAAGGTACTTTGGTGACGGTCTCGAGC >Sequence ID 293: αCD3***** VL Amino Acid Sequence DPVLTQSPSSLSASVGDRVTISCQSSQSVAKNNNLAWFQQKPGQAPKLLIYSASTLAAGVPSRFSGSGSGTDFTLTI SSVQPEDFATYYCSARDSGNIQSFGGGTKVEIK >Sequence ID 294: αCD3***** VL Nucleotide Sequence GATCCAGTTCTGACACAAAGTCCATCCAGCCTGTCTGCCTCAGTCGGCGACAGAGTGACCATCAGTTGCCAGAGCTC ACAGTCTGTGGCTAAGAACAACAACTTGGCGTGGTTCCAACAGAAACCTGGACAGGCTCCGAAATTGCTGATCTATT CTGCTTCCACGCTTGCTGCTGGTGTTCCTTCCCGCTTTTCAGGTAGTGGTAGCGGGACAGACTTCACTTTGACTATA AGCAGCGTGCAGCCTGAAGATTTTGCGACCTACTATTGTTCTGCTAGAGACAGTGGAAATATTCAGTCCTTTGGGGG GGGAACGAAGGTCGAAATAAAG >Sequence ID 295: NKG2D Monomer Amino Acid Sequence FLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHW MGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV >Sequence ID 296: NKG2D Monomer Nucleotide Sequence TTTCTGAATAGCCTGTTCAACCAGGAGGTGCAGATCCCACTGACCGAGAGCTATTGTGGACCTTGTCCTAAGAACTG GATCTGTTACAAGAACAACTGCTACCAGTTCTTCGACGAGAGCAAGAATTGGTATGAAAGCCAGGCCAGCTGCATGA GCCAAAACGCCTCTCTGCTGAAGGTGTACTCCAAAGAAGATCAGGACCTGCTGAAGCTGGTGAAGTCCTACCACTGG ATGGGCCTGGTGCACATCCCAACCAACGGCAGCTGGCAGTGGGAAGACGGCAGCATCCTGAGCCCTAACCTGCTGAC AATCATTGAGATGCAGAAAGGCGACTGCGCCCTGTACGCCAGTTCTTTTAAGGGCTACATCGAAAACTGTAGCACCC CTAACACCTACATCTGCATGCAGAGAACAGTG >Sequence ID 297: SI-75XM9 chain A amino acid sequence QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVY LKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSW NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEAAGGP SVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLN GKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYK TTPPVLDSDGSFFLVSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG >Sequence ID 298: SI-75XM9 chain A nucleotide sequence CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGG CATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCT TCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTAT TTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTG GGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAGGGACCCTCTGTGTTTCCTCTGGCTCCTTGCTCCA GATCCACCTCCGAGTCTACAGCTGCTCTGGGCTGCCTGGTCAAGGACTACTTTCCTGAGCCTGTGACCGTGTCCTGG AACTCTGGCGCTCTGACATCTGGCGTGCACACCTTTCCAGCTGTGCTGCAGTCCTCCGGCCTGTACTCTCTGTCCTC TGTCGTGACCGTGCCTTCCTCTAGCCTGGGCACCAAGACCTACACCTGTAATGTGGACCACAAGCCTTCCAACACCA AGGTGGACAAGCGCGTGGAATCTAAGTACGGCCCTCCTTGTCCTCCATGTCCTGCTCCAGAAGCTGCTGGCGGCCCA TCCGTGTTTCTGTTCCCTCCAAAGCCTAAGGACACCCTGATGATCTCTCGGACCCCTGAAGTGACCTGCGTGGTGGT GGATGTGTCCCAAGAGGATCCCGAGGTGCAGTTCAATTGGTACGTGGACGGCGTGGAAGTGCACAACGCCAAGACCA AGCCTAGAGAGGAACAGTTCAACTCCACCTACAGAGTGGTGTCCGTGCTGACCGTGCTGCACCAGGATTGGCTGAAC GGCAAAGAGTACAAGTGCAAGGTGTCCAACAAGGGCCTGCCTTCCAGCATCGAAAAGACCATCTCCAAGGCCAAGGG CCAGCCTAGGGAACCCCAGGTTTACACCCTGCCTCCAAGCCAAGAGGAAATGACCAAGAACCAGGTGTCCCTGTCCT GCGCCGTGAAGGGCTTCTACCCTTCCGATATCGCCGTGGAATGGGAGAGCAATGGCCAGCCTGAGAACAACTACAAG ACAACCCCTCCTGTGCTGGACTCCGACGGCTCCTTCTTCCTGGTGTCCCGCCTGACCGTGGACAAGTCCAGATGGCA AGAGGGCAACGTGTTCTCCTGCTCCGTGATGCACGAGGCCCTGCACAATCACTACACCCAGAAGTCCCTGTCTCTGT CCCTGGGATGA >Sequence ID 299: SI-75XM9 chain B amino acid sequence QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLII SGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCA ASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDR GVGYFDLWGRGTLVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLL IYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDE QLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNRGECGGGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVE VHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTK NQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNRFT QKSLSLSLG >Sequence ID 300: SI-75XM9 chain B nucleotide sequence CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCTGCACTGGAACCAG CAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATG ATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATC TCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGG CGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTG GAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCA GCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGC CAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACG CCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGT GGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGG TGGATCAGATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCC AGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTT ATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACT TACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCT TTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAG CAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAA GGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCC TCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGC CTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGCGGCGGACCTCCTTGTCCTCCATGTCCTGCTCC AGAAGCTGCTGGCGGCCCATCCGTGTTTCTGTTCCCTCCAAAGCCTAAGGACACCCTGATGATCTCTCGGACCCCTG AAGTGACCTGCGTGGTGGTGGATGTGTCCCAAGAGGATCCCGAGGTGCAGTTCAATTGGTACGTGGACGGCGTGGAA GTGCACAACGCCAAGACCAAGCCTAGAGAGGAACAGTTCAACTCCACCTACAGAGTGGTGTCCGTGCTGACCGTGCT GCACCAGGATTGGCTGAACGGCAAAGAGTACAAGTGCAAGGTGTCCAACAAGGGCCTGCCTTCCAGCATCGAAAAGA CCATCTCCAAGGCCAAGGGCCAGCCTAGGGAACCCCAGGTTTACACCCTGCCTCCAAGCCAAGAGGAAATGACCAAG AACCAGGTGTCCCTGTGGTGCCTCGTGAAGGGCTTCTACCCTTCCGATATCGCCGTGGAATGGGAGAGCAATGGCCA GCCTGAGAACAACTACAAGACAACCCCTCCTGTGCTGGACTCCGACGGCTCCTTCTTCCTGTATTCCCGCCTGACCG TGGACAAGTCCAGATGGCAAGAGGGCAACGTGTTCTCCTGCTCCGTGATGCACGAGGCCCTGCACAATCGCTTCACC CAGAAGTCCCTGTCTCTGTCCCTGGGATGA >Sequence ID 301: anti-CEA 656E11 CDR-H1 amino acid sequence GTQYVC >Sequence ID 302: anti-CEA 656E11 CDR-H2 amino acid sequence CIYVDVANTYYATSVKG >Sequence ID 303: anti-CEA 656E11 CDR-H3 amino acid sequence HDTVCAGCGLDL >Sequence ID 304: anti-CEA 656E11 CDR-L1 amino acid sequence QASENIYSNLA >Sequence ID 305: anti-CEA 656E11 CDR-L2 amino acid sequence DASTLAS >Sequence ID 306: anti-CEA 656E11 CDR-L3 amino acid sequence QSTYYNNIIYGAA >Sequence ID 307: anti-CD3 283E3 (BSM/FRS) CDR-H1 amino acid sequence SNAIG >Sequence ID 308: anti-CD3 283E3 (BSM/FRS) CDR-H2 amino acid sequence VIFGSGNTYYASWAKG >Sequence ID 309: anti-CD3 283E3 (BSM/FRS) CDR-H3 amino acid sequence GGYSSDI >Sequence ID 310: anti-CD3 283E3 (BSM/FRS) CDR-L1 amino acid sequence QSSQSVAKNNNLA >Sequence ID 311: anti-CD3 283E3 (BSM/FRS) CDR-L2 amino acid sequence SASTLAA >Sequence ID 312: anti-CD3 283E3 (BSM/FRS) CDR-L3 amino acid sequence SARDSGNIQS >Sequence ID 313: human IgG1 amino acid sequence ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLG TQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDP EVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQV YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSC SVMHEALHNHYTQKSLSLSPG >Sequence ID 314: human IgG4 amino acid sequence ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLG TKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQ FNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTL PPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVM HEALHNHYTQKSLSLSLG 

What is claimed is:
 1. A multi-specific antibody-like protein having a N-terminus and a C-terminus, comprising, a first monomer, comprising, from the N-terminus to the C-terminus, a first binding monomer, a CH1 domain, a first hinge, a first CH2 domain, and a first CH3 domain, wherein the first monomer comprises optionally a first binding domain (D1) linked to the N-terminus, a fourth binding domain (D4) linked to the C-terminus, or both, a second monomer, comprising, from the N-terminus to the C-terminus, a second binding monomer, a CL domain, a second hinge, a second CH2 domain, and a second CH3 domain, wherein the second monomer comprises optionally a second binding domain (D2) linked to the N-terminus, a fifth binding domain (D5) linked to the C-terminus, or both, wherein the first binding monomer and a second binding monomer are configured to form a dimer, wherein the first monomer and the second monomer are covalently paired through at least one disulfide bond between the CH1 domain and the CL domain and at least one disulfide bond between the first hinge and the second hinge, and wherein the multi-specific antibody-like protein is at least bi-specific.
 2. The multi-specific antibody-like protein of claim 1, wherein the first binding monomer comprises a VH domain, a second binding monomer comprises a VL domain, and wherein the VH, CH1, VL, CL domains form a Fab region as a third binding domain (D3).
 3. The multi-specific antibody-like protein of claim 1, wherein the first binding monomer and the second binding monomer form a NKG2D receptor as a third binding domain (D3).
 4. The multi-specific antibody-like protein of claim 1, wherein the first CH3 domain is configured to form a hole structure, wherein the second CH3 domain is configured to form a knob structure, and wherein the first CH2 and CH3 domains and the second CH2 and CH3 domains are configured to heterodimerize to form a complementary Fc domain.
 5. The multi-specific antibody-like protein of claim 1, wherein the D1, D2, D4, and D5 is independently a scFv domain, a VHH domain, a receptor, or a ligand.
 6. The multi-specific antibody-like protein of claim 1, wherein the D1, D2, D3, D4, and D5 each independently has a binding specificity against an antigen selected, EGFR, HER2, HER3, EGFRvIII, ROR1, CD3, CD28, CEA, LMP1, LMP2A, Mesothelin, PSMA, EpCAM, glypican-3, gpA33, GD2, TROP2, NKG2D, NKG2D ligand, BCMA, CD19, CD20, CD33, CD123, CD22, CD30, PD-L1, PD1, OX40, 4-1BB, GITR, TIGIT, TIM-3, LAG-3, CTLA4, CD40, CD40L, VISTA, ICOS, BTLA, LIGHT, HVEM, CSF1R, CD73, CD39, CLDN18.2, DLL3, HLA-G, FcRH5, GPRC5D, LIV-1, MUC1, CD138, CD70, CD16, uPAR, Siglec-15, CD47, CD38, NKp46, PD-L2, CD160, LOX-1, SIRPα, CD27 and wherein the Fc domain comprises a human IgG Fc domain.
 7. The multi-specific antibody-like protein of claim 1, wherein D1 has a binding specificity to CD3, CD20, CEA, HER2, EGFR, or NKG2D ligand.
 8. The multi-specific antibody-like protein of claim 1, wherein D2 has a binding specificity to HER3, EGFR, CD3, or CD19.
 9. The multi-specific antibody-like protein of claim 1, wherein D3 has a binding specificity to HER3, EGFR, CD3, or NKG2D ligands.
 10. The multi-specific antibody-like protein of claim 1, wherein D4 has a binding specificity to 4-1BB, or EGFR.
 11. The multi-specific antibody-like protein of claim 1, wherein D5 has a binding specificity to PD-L1 or HER3.
 12. The multi-specific antibody-like protein of claim 1, wherein the antibody is a tri-specific antibody having the binding specificity to EGFR, HER3, and CD3.
 13. The multi-specific antibody-like protein of claim 1, wherein the antibody is a tetra-specific antibody having the binding specificity to EGFR, HER3, CD3, and 4-1BB.
 14. The multi-specific antibody-like protein of claim 1, wherein the antibody is a tetra-specific antibody having the binding specificity to EGFR, HER3, CD3, and PD-L1.
 15. The multi-specific antibody-like protein of claim 1, wherein the antibody is a penta-specific antibody having the binding specificity to EGFR, HER3, CD3, 4-1BB and PD-L1.
 16. A complimentary determining region (CDR) having an affinity to CEA, comprising an amino acid sequence having sequence identity to SEQ ID NO. 301, 302, 303, 304, 305, or
 306. 17. A protein having an affinity to CEA, comprising the CDR of claim
 16. 18. A multi-specific antibody-like protein having a binding affinity to CEA, wherein the antibody-like protein comprises an amino acid sequence having sequence identity to an amino acid sequence selected from SEQ ID NO. 279, 280, 281 or
 282. 19. A complimentary determining region (CDR) having a binding affinity to CD3, comprising an amino acid sequence having sequence identity to SEQ ID NO. 307, 308, 309, 310, 311 or
 312. 20. A protein having an affinity to CD3, comprising CDR of claim
 19. 21. A multi-specific antibody-like protein having a binding affinity to CD3, wherein the antibody-like protein comprises an amino acid sequence having sequence identity to an amino acid sequence selected from SEQ ID NO. 227-230, 231-234, 235-238, 239-242 and 291-294.
 22. An isolated nucleic acid sequence encoding the multi-specific antibody-like protein of claim
 1. 23. An expression vector comprising the isolated nucleic acid sequences of claim
 22. 24. A host cell comprising the isolated nucleic acid sequence of claim
 22. 25. An immunoconjugate comprising the multi-specific antibody-like protein of claim 1 and a cytotoxic agent.
 26. A pharmaceutical composition, comprising the multi-specific antibody-like protein of claim 1 and a pharmaceutically acceptable carrier.
 27. A pharmaceutical composition, comprising the immunoconjugate of claim 25 and a pharmaceutically acceptable carrier.
 28. A method for treating or preventing a cancer, an autoimmune disease, or an infectious disease in a subject, said method comprising administering to the subject a pharmaceutical composition comprising a purified multi-specific antibody-like protein of claim
 1. 29. A method for producing the multi-specific antibody-like protein of claim 1, comprising culturing a host cell such that the DNA sequence encoding the multi-specific antibody-like protein of claim 1 is expressed, and purifying said multi-specific antibody-like protein.
 30. (canceled) 